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Incidence of Drug Resistance on the Mycobacterial Strains Isolated from Treated and Untreated Patients

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Book cover Special Problems in Chemotherapy

Part of the book series: Chemotherapy ((CT,volume 3))

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Summary

The resistances of 308 strains of mycobacteria were studied by means of the technique of Canetti, Rist and Grosset, against seven antituberculosis drugs. Two hundred and ninety-four of the strains were identified as M. tuberculosis, and fourteen as atypical mycobacteria. All strains were of human origin.

The strains of M. tuberculosis isolated from untreated patients (110 strains) were sensitive to Rifampicin and Ethambutol, while those isolated from treated patients showed variable resistance to the drugs used. The highest percentages of resistances were those of Isoniazid (42.3%), Streptomycin (29.8%) and p-Aminosalicylic acid (22%).

The atypical mycobacteria strains showed a higher resistance disregarding their origin from treated or untreated patients.

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References

  • CANETTI, G.; RIST, N., and GROSSET, J, (1963). - “Mesure de la sensibilité du bacille tuberculeux aux drogues antibacillaires par la méthode des proportions. Méthodologie, cri-téres de résistance, résultats interprétation”. - Rev. Tub, Pneu-mol. 27. 217

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  • TACQUET, A., and TISON, F. (1961). “Nouvelle téchnique dtisolement des mycobactéries par le lauryl-sulfate de sodium”. Ann. Inst. Pasteur 100, 676.

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Author information

Authors and Affiliations

  1. Microbiology Department, Faculty of Medicine, University of Salamanca, Fonseca, 2, Spain

    J. A. Garcia, M. C. Saenz, J. Prieto & F. Martin

Authors
  1. J. A. Garcia
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  2. M. C. Saenz
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  3. J. Prieto
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  4. F. Martin
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Editor information

Editors and Affiliations

  1. The London Hospital Medical College, London, UK

    J. D. Williams

  2. East Birmingham Hospital, Birmingham, UK

    A. M. Geddes

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© 1976 Plenum Press, New York

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Garcia, J.A., Saenz, M.C., Prieto, J., Martin, F. (1976). Incidence of Drug Resistance on the Mycobacterial Strains Isolated from Treated and Untreated Patients. In: Williams, J.D., Geddes, A.M. (eds) Special Problems in Chemotherapy. Chemotherapy, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3120-9_13

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  • DOI: https://doi.org/10.1007/978-1-4684-3120-9_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3122-3

  • Online ISBN: 978-1-4684-3120-9

  • eBook Packages: Springer Book Archive

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