Abstract
The central cholinergic synapses which constitute the subject of this paper are those at which the transmission between the presynaptic and the postsynaptic neuron — or, more precisely, between the presynaptic nerve terminal and the postsynaptic membrane — is mediated by acetylcholine (ACh); a complication may arise from the fact that at certain, non-cholinergic synapses ACh may play a modulatory, facilitatory rather than transmissive role. In view of the wide occurrence (cf. below) of the cholinergic synapses or modulations, the cholinergic system must participate significantly in brain functions and behavioral processes* In fact, several participants of this Symposium discussed the cholinergic participation in the appetitive and thermal control (R.D. Myers), in conditioning and learning (H. Brust-Carmona), in aggression (D.J. Reis), and in certain phases of sleep (P. Morgane); related aspects of the cholinergic system were described by others (Domino, 1968; Domino et al., 1968; Bovet-Nitti, 1965; Aprison, 1965; Stein, 1968; Karczmar et al., 1972; Karczmar, 1971).
The published and unpublished results from our laboratories described in this newspaper were supported in part by the USA-NIH and USA-NIH Training Grant GM77.
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Karczmar, A.G. (1974). The Chemical Coding Via the Cholinergic System: Its Organization and Behavioral Implications. In: Myers, R.D., Drucker-Colín, R.R. (eds) Neurohumoral Coding of Brain Function. Advances in Behavioral Biology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3066-0_21
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