Skip to main content

The Possible Nature of Sleep Inducing Brain Perfusates: Their Relationship to Seizure Inhibition

  • Chapter
Neurohumoral Coding of Brain Function

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 10))

Abstract

The search for a relationship between a particular neurotransmitter and a certain type of behavior has become somewhat of a scientific vogue. Yet, despite the vast literature on the subject and despite some direct demonstrations that neurohumors are released as a result of synaptic activity or nerve function (McLennan, 1964; Baldessarini and Kopin, 1966; Szerb, 1967; Yaksh and Myers, 1972), there is little evidence showing that a particular behavior or behavioral component is induced as a result of a neurohumor acting locally at a brain site. As Kety (1967) has suggested)when we come to behavioral-neurohumoral relationships, we find that most of the evidence depends on indirect pharmacological studies, whose drawbacks are many, with perhaps the most important one being related to the multiplicity of effects induced by any one drug.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Allison T. and Van Twyver H. 1970, The evolution of sleep Natural History 79: 56.

    Google Scholar 

  • Baldessarini, R.J. and Kopin, I.J. 1966, Tritiated norepinephrine: release from brain slices by electrical stimulation, Science, 149: 450.

    Google Scholar 

  • Berlucchi, G. 1965, Callosal activity in unrestrained, unanesthetized cats, Arch. Ital. Biol 103: 623.

    PubMed  CAS  Google Scholar 

  • Bjorklund, A., Falck, B. and Stenevi, U. 1971, Classification of monoamine neurons in the rat mesencephalon: distribution of a new monoamine neurone system, Brain Res, 32: 269.

    Article  PubMed  CAS  Google Scholar 

  • Bremer, F. 1970a, Inhibitions intrathalamiques recurrentielles et physiologie du sommeil, EEG. Clin Neurophysiol, 28: 1

    Article  CAS  Google Scholar 

  • Bremer, F. 1970b, Preoptic hypnogenic focus and mesence-phalic reticular formation, Brain Res, 21: 132.

    Article  PubMed  CAS  Google Scholar 

  • Brooks, D.C. and Gershon, M.D. 1971, Eye movement potentials in the oculomotor and visual systems of the cat: a comparison of reserpine induced waves with those present during wakefulness and rapid eye movement sleep, Brain Res, 27: 223.

    Article  PubMed  CAS  Google Scholar 

  • Brooks, D.C., Gershon, M.D. and Simon, R.P. 1972, Brain stem serotonin depletion and pontogeniculo-occipital wave activity in the cat treated with reserpine, Neuropharmacol, 11: 511.

    Article  CAS  Google Scholar 

  • Cohen, H.B. and Dement, W.C. 1965, Sleep: changes in threshold to electroconvulsive shock in rats after deprivation of “paradoxical” phase, Science, 150: 1318.

    Article  PubMed  CAS  Google Scholar 

  • Cohen, H.B. and Dement, W.C. 1966, Sleep: suppression of rapid eye movement phase in the cat after electroconvulsive shock. Science 154: 396.

    Article  PubMed  CAS  Google Scholar 

  • Cohen, H.B., Duncan,R.F. and Dement, W.C. 1967, Sleep: the effect of eleetroconvulsiveshock in cats deprived of REM sleep, Science 156: 1646.

    Article  PubMed  CAS  Google Scholar 

  • Cohen, H.B., Duncan, R.F. and Dement, W.C. 1968, The effect of diphenylhydantoin on sleep in the cat, EEG. Clin. Neurophysiol 24: 401.

    Article  CAS  Google Scholar 

  • Drucker-Colin, R.R. 1972, Transmisión neurohumoral en el sueño: efecto del líquido de perfusion obtenido de la formación reticular mesencefálica (FRM) XV Congreso Nacional de Ciencias Fisiológicas pp. 8.

    Google Scholar 

  • Drucker-Colin, R.R. 1973, Crossed perfusion of a sleep inducing brain tissue substance in conscious cats, Brain Res, 56: 123.

    Article  PubMed  CAS  Google Scholar 

  • Drucker-Colín, R.R., Rojas-Ramirez, J.A., Vera-Trueba, J., Monroy-Ayala, G., Hernández-Peon, R. 1970, Effect of crossed perfusion of the mid-brain reticular formation upon sleep, Brain Res. 23: 269.

    Article  PubMed  Google Scholar 

  • Dow, R.S., Fernandez-Guardiola, A. and Manni, E. 1962, The influence of the cerebellum on experimental epilepsy, EEG. Clin. Neurophysiol, 14: 383.

    Article  CAS  Google Scholar 

  • Feeney, D.M. and Gullotta, F.P. 1972, Suppression of seizure discharges and sleep spindles by lesions of the rostral thalamus, Brain Res, 45: 254.

    Article  PubMed  CAS  Google Scholar 

  • Fencl, V., Koski, G. and Pappenheimer, J.R. 1971, Factors in cerebrospinal fluid from goats that affect sleep and activity in rats, J. Physiol (Lond.) 216: 565.

    CAS  Google Scholar 

  • Ferguson, J.M. and Dement, W.C. 1967, The effect of variations in total sleep time on the occurrence of rapid eye movement sleep in cats, EEG. Clin. Neurophysiol, 22: 2

    Article  CAS  Google Scholar 

  • Fernandez-Guardiola, A. and Ayala, F. 1971, Red nucleus fast activity and signs of paradoxical sleep appearing during the extinction of experimental seizures. EEG. Clin. Neurophysiol 30: 547.

    Article  CAS  Google Scholar 

  • Flanigan, W.F., Wilcox, R.H. and Rechtschaffen, A. 1973, The EEG and behavioral continuum of the crocodilian, Caiman Sclerops. EEG. Clin. Neurophysiol, 34: 521.

    Article  Google Scholar 

  • Gaddum, J.H. 1961, Push-Pull Cannulae, J. Physiol. (Lond.) 155: 1.

    Google Scholar 

  • Gastaut, H. and Fischer-Williams, M. 1959, The physiopathology of epileptic seizures, in Handbook of Physiology ( Field, J., Magoun, HW and Hall, V.E. eds. pp. 329–363, American Physiological Society, Washington.

    Google Scholar 

  • Hartmann, E.L. 1969, The biochemistry and pharmacology of the D-state (dreaming sleep) Exptl. Med. Surg, 27: 10 5

    Google Scholar 

  • Hernandez-Peon, R. 1965, A cholinergic hypnogenic limbic forebrain hindbrain circuit, in Aspects Anatomofonctionnels du Sommeil ( Jouvet, M. ed.) pp. 63–88. Centre National de la Recherche Scientifique, Paris.

    Google Scholar 

  • Hernandez-Peon, R. and Drucker-Colin, R.R. 1970, A neuronography study of cortico-bulbar hypnogenic pathways. Physiol Beh. 5: 721.

    Article  CAS  Google Scholar 

  • Hodes, R. 1964, Electrocortical desynchronization resulting from spinal block: evidence for synchronizing influences in the cervical cord, Arch. Ital. Biol, 102: 183.

    PubMed  CAS  Google Scholar 

  • Jouvet, M. 1967, The states of sleep, Scientific Amer, 216: 62.

    Article  CAS  Google Scholar 

  • Jouvet, M. 1969, Biogenic amines and the states of sleep. Science, 16 3: 32.

    Article  Google Scholar 

  • Jouvet, M. 1972, The role of monoamines and acetylcholine containing neurons in the regulation of the sleep-waking cycle., Ergbn. Physiol. 6 4: 166.

    Google Scholar 

  • Jouvet-Monnier, D., Astic, L. Lacote, D. 1970, Ontogenesis of the states of sleep in rat, cat and guinea pig during the first postnatal month. Develop. Psychobiol 2: 216.

    Article  Google Scholar 

  • Kety, S.S. 1967, The central physiological and pharmacological effects of the biogenic amines and their correlations with behavior, in The Neurosciences ( Quarton, G. C Melnechuk, T. and Schmitt, C. eds.) pp. 444–451, Rockefeller Univ. Press, N.Y.

    Google Scholar 

  • Kusske, J., Ojemman, G. A. and Ward, A. H. 1972, Effects of lesions of the ventral anterior thalamus on experimental focal epilepsy. Exp. N eurol, 34: 279.

    Article  CAS  Google Scholar 

  • Legendre, R. and Pieron, H. 1911, Du development, an cours de 1’insonnie experimental, des propriétés hypnotoxiques des humeurs en relation avec le besoin croissant de sommeil, C. R. Soc. Biol. (Paris) 70: 190.

    CAS  Google Scholar 

  • Lenard, H.G. and Schulte, F.J. 1972, Polygraphie sleep study in craniopagus twins, J. Neurosurg. Psychiat, 35: 756.

    Article  CAS  Google Scholar 

  • Lennox-Buchtal, M.A. 1973, Febrile Convulsions: a Reappraisal, EEG. Clin. Neurophysiol. Suppl. 3, 2: 1.

    Google Scholar 

  • Lovell, R.A. 1971, Some neurochemical aspects of convulsions, in “Handbook of Neurochemistry” (Lajtha, A. ed.) pp. 63–102. Plenum Press, N.Y.

    Google Scholar 

  • Mazzuchelli-O’Flaherty, H.L., O’Flaherty, J.J. and Hernandez-Peon, R. 1967, Sleep and other behavioral responses induced by acetylcholinic stimulation of the frontal and mesial cortex, Brain Res, 4: 268.

    Article  PubMed  Google Scholar 

  • McLennan, H. 1964, The release of acetylcholine and of 3-hydroxytyramine from the caudate nucleus, J. Physiol. (London) 174: 152.

    CAS  Google Scholar 

  • Monnier, M. and Hatt, A.M. 1971, Humoral transmission in sleep, V. New evidence from production of pure sleep hemodialys ate, Pflugers. Arch, ges. Physiol 329: 231.

    Article  CAS  Google Scholar 

  • Monnier, M. and Hosli, L. 1964, Dialysis of sleep and waking factors in blood of the rabbit, Science 146: 796.

    Article  PubMed  CAS  Google Scholar 

  • Morgane, P.J. and Stern, W.C. 1973, Effects of serotonin metabolites on sleep-waking activity in cats, Brain Res, 50: 205.

    Article  PubMed  CAS  Google Scholar 

  • Moruzzi, G. 1972, The sleep-waking cycle, Ergebn. Physiol. 64: 1.

    PubMed  CAS  Google Scholar 

  • Myers, R.D. and Beleslin, A. B. 1971, Changes In serotonin release in hypothalamus during cooling and warming in the monkey, Amer. J. Physiol, 220: 1746.

    PubMed  CAS  Google Scholar 

  • Pappenheimer, J.R., Miller, T.B. and Goodrich, C.A. 1967, Sleep promoting effects of cerebrospinal fluid from sleep deprived goats, Proc. int. Acad. Sci. (Wash.) 58: 543.

    Google Scholar 

  • Pieron, H. 1913, Le probléme physiologique du sommeil. Masson, Paris pp. 520.

    Google Scholar 

  • Pompeiano, O. 1969, Sleep Mechanisms in “The Basic Mechanisms of the Epilepsies” (Jasper, H.H., Ward, H.A. and Pope A. eds.) pp. 453–473. Little Brown Co. Boston

    Google Scholar 

  • Pompeiano, O. and Swett, J.E. 1962, EEG and behavioral manifestations of sleep induced by cutaneous nerve stimulation in normal cats, Arch. Ital. Biol, 100: 343

    PubMed  CAS  Google Scholar 

  • Rechtschaffen, A.,Lovell, R.H., Freedman, D.X., Whitehead, W.E. and Aldrich, M. 1972, The effect of para- chlor©phenylalanine on sleep in the rat: some implications for the serotonin-sleep hypothesis. Conference on Serotonin and Behavior, Stanford University.

    Google Scholar 

  • Ringle, D.A. and Herndon, B.C. 1969, Effects on rats of CSF from sleep-deprived rabbits, Pflugers Arch, ges. Physiol, 306: 320.

    Article  CAS  Google Scholar 

  • Roffwarg, H. P., Muzio, J.N. and Dement, W.C. 1966, Ontogenetic development of the human sleep-dream cycle. Science, 152: 604.

    Article  PubMed  CAS  Google Scholar 

  • Rojas-Ramírez, J.A. and Drucker-Colín, R.R. 1973, Sleep induced by spinal cord cholinergic stimulation, Int. J. Neurosciences, in Press.

    Google Scholar 

  • Rossi, G.F., Favale, E., Hara, T., Guisani, A. and Sacco, G. 1961, Researches on the neurons mechanisms underlying deep sleep in the cat, Arch. Ital. Biol,99:270,

    Google Scholar 

  • Satinoff, E., Drucker-Colín, R.R. and Hernandez-Peon, R. 1971, Paleocortical excitability and sensory filtering during REM sleep deprivation, Physiol. Beh 7: 103.

    Article  CAS  Google Scholar 

  • Schnedorf, J.G. and Ivy, A.C. 1939, On examination of the hypnotoxin theory of sleep, Amer. J. Physiol 125: 491.

    Google Scholar 

  • Schoenenberger, G.A., Cueni, L.B., Hatt, A.M. and Monnier M. 1972, Isolation and physical-chemical characterization of a humoral sleep inducing substance in rabbits (Factor Delta), Experientia, 28: 919.

    Article  PubMed  CAS  Google Scholar 

  • Servit, Z. 1962, Phylogenesis and ontogenesis of the epileptic seizure, World Neurol. 3: 259.

    PubMed  CAS  Google Scholar 

  • Sterman, M.B. and Clemente, C.D. 1962, Forebrain inhibition mechanisms: sleep patterns induced by basal fore-brain stimulation in the behaving cat, Exp. Neurol, 6: 103.

    Article  PubMed  CAS  Google Scholar 

  • Szerb, J.C. 1967, Cortical acetylcholine release and electroencephalographic arousal. J. Physiol. (London) 192: 329.

    CAS  Google Scholar 

  • Yaksh, T.L. and Myers, R.D. 1972, Neurohumoral substances released from hypothalamus of the monkey during hunger and satiety, Amer. J. Physiol 222: 503.

    PubMed  CAS  Google Scholar 

  • Yamaguchi, N., Ling, G.M. and Marczynski,T.J. 1964, Re-cruiting responses observed during wakefulness and sleep in unanesthetized chronic cats, EEG. Clin. Neurophysiol, 17: 246.

    Article  CAS  Google Scholar 

  • Wyatt, R.J. 1972, The serotonin-catecholamine dream bicycle. A clinical study, Biol. Psy chiat 5: 73.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1974 Plenum Press, New York

About this chapter

Cite this chapter

Drucker-Colin, R.R. (1974). The Possible Nature of Sleep Inducing Brain Perfusates: Their Relationship to Seizure Inhibition. In: Myers, R.D., Drucker-Colín, R.R. (eds) Neurohumoral Coding of Brain Function. Advances in Behavioral Biology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3066-0_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-3066-0_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3068-4

  • Online ISBN: 978-1-4684-3066-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics