Abstract
The search for a relationship between a particular neurotransmitter and a certain type of behavior has become somewhat of a scientific vogue. Yet, despite the vast literature on the subject and despite some direct demonstrations that neurohumors are released as a result of synaptic activity or nerve function (McLennan, 1964; Baldessarini and Kopin, 1966; Szerb, 1967; Yaksh and Myers, 1972), there is little evidence showing that a particular behavior or behavioral component is induced as a result of a neurohumor acting locally at a brain site. As Kety (1967) has suggested)when we come to behavioral-neurohumoral relationships, we find that most of the evidence depends on indirect pharmacological studies, whose drawbacks are many, with perhaps the most important one being related to the multiplicity of effects induced by any one drug.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Allison T. and Van Twyver H. 1970, The evolution of sleep Natural History 79: 56.
Baldessarini, R.J. and Kopin, I.J. 1966, Tritiated norepinephrine: release from brain slices by electrical stimulation, Science, 149: 450.
Berlucchi, G. 1965, Callosal activity in unrestrained, unanesthetized cats, Arch. Ital. Biol 103: 623.
Bjorklund, A., Falck, B. and Stenevi, U. 1971, Classification of monoamine neurons in the rat mesencephalon: distribution of a new monoamine neurone system, Brain Res, 32: 269.
Bremer, F. 1970a, Inhibitions intrathalamiques recurrentielles et physiologie du sommeil, EEG. Clin Neurophysiol, 28: 1
Bremer, F. 1970b, Preoptic hypnogenic focus and mesence-phalic reticular formation, Brain Res, 21: 132.
Brooks, D.C. and Gershon, M.D. 1971, Eye movement potentials in the oculomotor and visual systems of the cat: a comparison of reserpine induced waves with those present during wakefulness and rapid eye movement sleep, Brain Res, 27: 223.
Brooks, D.C., Gershon, M.D. and Simon, R.P. 1972, Brain stem serotonin depletion and pontogeniculo-occipital wave activity in the cat treated with reserpine, Neuropharmacol, 11: 511.
Cohen, H.B. and Dement, W.C. 1965, Sleep: changes in threshold to electroconvulsive shock in rats after deprivation of “paradoxical” phase, Science, 150: 1318.
Cohen, H.B. and Dement, W.C. 1966, Sleep: suppression of rapid eye movement phase in the cat after electroconvulsive shock. Science 154: 396.
Cohen, H.B., Duncan,R.F. and Dement, W.C. 1967, Sleep: the effect of eleetroconvulsiveshock in cats deprived of REM sleep, Science 156: 1646.
Cohen, H.B., Duncan, R.F. and Dement, W.C. 1968, The effect of diphenylhydantoin on sleep in the cat, EEG. Clin. Neurophysiol 24: 401.
Drucker-Colin, R.R. 1972, Transmisión neurohumoral en el sueño: efecto del líquido de perfusion obtenido de la formación reticular mesencefálica (FRM) XV Congreso Nacional de Ciencias Fisiológicas pp. 8.
Drucker-Colin, R.R. 1973, Crossed perfusion of a sleep inducing brain tissue substance in conscious cats, Brain Res, 56: 123.
Drucker-Colín, R.R., Rojas-Ramirez, J.A., Vera-Trueba, J., Monroy-Ayala, G., Hernández-Peon, R. 1970, Effect of crossed perfusion of the mid-brain reticular formation upon sleep, Brain Res. 23: 269.
Dow, R.S., Fernandez-Guardiola, A. and Manni, E. 1962, The influence of the cerebellum on experimental epilepsy, EEG. Clin. Neurophysiol, 14: 383.
Feeney, D.M. and Gullotta, F.P. 1972, Suppression of seizure discharges and sleep spindles by lesions of the rostral thalamus, Brain Res, 45: 254.
Fencl, V., Koski, G. and Pappenheimer, J.R. 1971, Factors in cerebrospinal fluid from goats that affect sleep and activity in rats, J. Physiol (Lond.) 216: 565.
Ferguson, J.M. and Dement, W.C. 1967, The effect of variations in total sleep time on the occurrence of rapid eye movement sleep in cats, EEG. Clin. Neurophysiol, 22: 2
Fernandez-Guardiola, A. and Ayala, F. 1971, Red nucleus fast activity and signs of paradoxical sleep appearing during the extinction of experimental seizures. EEG. Clin. Neurophysiol 30: 547.
Flanigan, W.F., Wilcox, R.H. and Rechtschaffen, A. 1973, The EEG and behavioral continuum of the crocodilian, Caiman Sclerops. EEG. Clin. Neurophysiol, 34: 521.
Gaddum, J.H. 1961, Push-Pull Cannulae, J. Physiol. (Lond.) 155: 1.
Gastaut, H. and Fischer-Williams, M. 1959, The physiopathology of epileptic seizures, in Handbook of Physiology ( Field, J., Magoun, HW and Hall, V.E. eds. pp. 329–363, American Physiological Society, Washington.
Hartmann, E.L. 1969, The biochemistry and pharmacology of the D-state (dreaming sleep) Exptl. Med. Surg, 27: 10 5
Hernandez-Peon, R. 1965, A cholinergic hypnogenic limbic forebrain hindbrain circuit, in Aspects Anatomofonctionnels du Sommeil ( Jouvet, M. ed.) pp. 63–88. Centre National de la Recherche Scientifique, Paris.
Hernandez-Peon, R. and Drucker-Colin, R.R. 1970, A neuronography study of cortico-bulbar hypnogenic pathways. Physiol Beh. 5: 721.
Hodes, R. 1964, Electrocortical desynchronization resulting from spinal block: evidence for synchronizing influences in the cervical cord, Arch. Ital. Biol, 102: 183.
Jouvet, M. 1967, The states of sleep, Scientific Amer, 216: 62.
Jouvet, M. 1969, Biogenic amines and the states of sleep. Science, 16 3: 32.
Jouvet, M. 1972, The role of monoamines and acetylcholine containing neurons in the regulation of the sleep-waking cycle., Ergbn. Physiol. 6 4: 166.
Jouvet-Monnier, D., Astic, L. Lacote, D. 1970, Ontogenesis of the states of sleep in rat, cat and guinea pig during the first postnatal month. Develop. Psychobiol 2: 216.
Kety, S.S. 1967, The central physiological and pharmacological effects of the biogenic amines and their correlations with behavior, in The Neurosciences ( Quarton, G. C Melnechuk, T. and Schmitt, C. eds.) pp. 444–451, Rockefeller Univ. Press, N.Y.
Kusske, J., Ojemman, G. A. and Ward, A. H. 1972, Effects of lesions of the ventral anterior thalamus on experimental focal epilepsy. Exp. N eurol, 34: 279.
Legendre, R. and Pieron, H. 1911, Du development, an cours de 1’insonnie experimental, des propriétés hypnotoxiques des humeurs en relation avec le besoin croissant de sommeil, C. R. Soc. Biol. (Paris) 70: 190.
Lenard, H.G. and Schulte, F.J. 1972, Polygraphie sleep study in craniopagus twins, J. Neurosurg. Psychiat, 35: 756.
Lennox-Buchtal, M.A. 1973, Febrile Convulsions: a Reappraisal, EEG. Clin. Neurophysiol. Suppl. 3, 2: 1.
Lovell, R.A. 1971, Some neurochemical aspects of convulsions, in “Handbook of Neurochemistry” (Lajtha, A. ed.) pp. 63–102. Plenum Press, N.Y.
Mazzuchelli-O’Flaherty, H.L., O’Flaherty, J.J. and Hernandez-Peon, R. 1967, Sleep and other behavioral responses induced by acetylcholinic stimulation of the frontal and mesial cortex, Brain Res, 4: 268.
McLennan, H. 1964, The release of acetylcholine and of 3-hydroxytyramine from the caudate nucleus, J. Physiol. (London) 174: 152.
Monnier, M. and Hatt, A.M. 1971, Humoral transmission in sleep, V. New evidence from production of pure sleep hemodialys ate, Pflugers. Arch, ges. Physiol 329: 231.
Monnier, M. and Hosli, L. 1964, Dialysis of sleep and waking factors in blood of the rabbit, Science 146: 796.
Morgane, P.J. and Stern, W.C. 1973, Effects of serotonin metabolites on sleep-waking activity in cats, Brain Res, 50: 205.
Moruzzi, G. 1972, The sleep-waking cycle, Ergebn. Physiol. 64: 1.
Myers, R.D. and Beleslin, A. B. 1971, Changes In serotonin release in hypothalamus during cooling and warming in the monkey, Amer. J. Physiol, 220: 1746.
Pappenheimer, J.R., Miller, T.B. and Goodrich, C.A. 1967, Sleep promoting effects of cerebrospinal fluid from sleep deprived goats, Proc. int. Acad. Sci. (Wash.) 58: 543.
Pieron, H. 1913, Le probléme physiologique du sommeil. Masson, Paris pp. 520.
Pompeiano, O. 1969, Sleep Mechanisms in “The Basic Mechanisms of the Epilepsies” (Jasper, H.H., Ward, H.A. and Pope A. eds.) pp. 453–473. Little Brown Co. Boston
Pompeiano, O. and Swett, J.E. 1962, EEG and behavioral manifestations of sleep induced by cutaneous nerve stimulation in normal cats, Arch. Ital. Biol, 100: 343
Rechtschaffen, A.,Lovell, R.H., Freedman, D.X., Whitehead, W.E. and Aldrich, M. 1972, The effect of para- chlor©phenylalanine on sleep in the rat: some implications for the serotonin-sleep hypothesis. Conference on Serotonin and Behavior, Stanford University.
Ringle, D.A. and Herndon, B.C. 1969, Effects on rats of CSF from sleep-deprived rabbits, Pflugers Arch, ges. Physiol, 306: 320.
Roffwarg, H. P., Muzio, J.N. and Dement, W.C. 1966, Ontogenetic development of the human sleep-dream cycle. Science, 152: 604.
Rojas-Ramírez, J.A. and Drucker-Colín, R.R. 1973, Sleep induced by spinal cord cholinergic stimulation, Int. J. Neurosciences, in Press.
Rossi, G.F., Favale, E., Hara, T., Guisani, A. and Sacco, G. 1961, Researches on the neurons mechanisms underlying deep sleep in the cat, Arch. Ital. Biol,99:270,
Satinoff, E., Drucker-Colín, R.R. and Hernandez-Peon, R. 1971, Paleocortical excitability and sensory filtering during REM sleep deprivation, Physiol. Beh 7: 103.
Schnedorf, J.G. and Ivy, A.C. 1939, On examination of the hypnotoxin theory of sleep, Amer. J. Physiol 125: 491.
Schoenenberger, G.A., Cueni, L.B., Hatt, A.M. and Monnier M. 1972, Isolation and physical-chemical characterization of a humoral sleep inducing substance in rabbits (Factor Delta), Experientia, 28: 919.
Servit, Z. 1962, Phylogenesis and ontogenesis of the epileptic seizure, World Neurol. 3: 259.
Sterman, M.B. and Clemente, C.D. 1962, Forebrain inhibition mechanisms: sleep patterns induced by basal fore-brain stimulation in the behaving cat, Exp. Neurol, 6: 103.
Szerb, J.C. 1967, Cortical acetylcholine release and electroencephalographic arousal. J. Physiol. (London) 192: 329.
Yaksh, T.L. and Myers, R.D. 1972, Neurohumoral substances released from hypothalamus of the monkey during hunger and satiety, Amer. J. Physiol 222: 503.
Yamaguchi, N., Ling, G.M. and Marczynski,T.J. 1964, Re-cruiting responses observed during wakefulness and sleep in unanesthetized chronic cats, EEG. Clin. Neurophysiol, 17: 246.
Wyatt, R.J. 1972, The serotonin-catecholamine dream bicycle. A clinical study, Biol. Psy chiat 5: 73.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1974 Plenum Press, New York
About this chapter
Cite this chapter
Drucker-Colin, R.R. (1974). The Possible Nature of Sleep Inducing Brain Perfusates: Their Relationship to Seizure Inhibition. In: Myers, R.D., Drucker-Colín, R.R. (eds) Neurohumoral Coding of Brain Function. Advances in Behavioral Biology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3066-0_14
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3066-0_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3068-4
Online ISBN: 978-1-4684-3066-0
eBook Packages: Springer Book Archive