Nucleic Acids, Peptides, and Proteins
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The roles played by the solvent and small solute-solvent interactions in aqueous solutions of proteins, polypeptides, and nucleic acids are in many aspects far from clear; the total effort which has so far been expended in advancing our knowledge of the phenomena has been quite considerable and yet many problems and anomalies remain to be explained. It is unfortunately not possible within the space limitations of a review of this kind to encompass the whole of the work performed within this field over the past few years. The best that one can hope to accomplish is to describe, in outline, some of the models proposed by several outstanding workers in the field which are helping to clarify a complex situation; additionally, we may summarize the evidence supporting such interpretations and that which points to the limitations of our knowledge at the present time. This, in turn, may serve as a warning against the dangers inherent in overenthusiastic interpretation of limited experimental data in complex situations.
KeywordsPolymethacrylic Acid Peptide Group Hydrophobic Hydration Hydrophobic Bonding Random Coil Conformation
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