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Reserpine

  • Chapter
Poisons of Plant Origin

Abstract

Reserpine, an alkaloid obtained from the roots of Rauwolfia serpentina (Fig. 1) and related species, is one of the drugs of antiquity. Primitive doctors have used Rauwolfia to treat a wide variety of diseases (Raymond-Hamet, 1939), and at least two of these actions have found a place in modern therapeutics, namely the antihypertensive and tranquilizing properties. In this respect, it is interesting to note that one of the common ancient names of Rauwolfia translates as “madman’s medicine” (Saxton, 1960). References to the actions of Rauwolfia in the European literature date back to the sixteenth century (Rieppel, 1955), and the genus was named a century later in honor of Leonhard Rauwolf (d. 1596), an Augsburg physician who probably was not even acquainted with the plants (Rieppel, 1955). The first detailed description of the medicinal uses of Rauwolfia appeared in Rumpf’s Herbarii Amboinensis Auctuarium (1755).

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Duke University Medical Center, Durham, North Carolina, USA

    Theodore A. Slotkin

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  1. Theodore A. Slotkin
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  1. Department of Pharmacology College of Physicians and Surgeons, Columbia University, New York, New York, USA

    Lance L. Simpson

  2. Department of Psychiatry College of Physicians and Surgeons, Columbia University, New York, New York, USA

    Lance L. Simpson

  3. Department of Pharmacology, Australian National University, Canberra, Australia

    David R. Curtis

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© 1974 Plenum Press, New York

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Slotkin, T.A. (1974). Reserpine. In: Simpson, L.L., Curtis, D.R. (eds) Poisons of Plant Origin. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2943-5_1

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  • DOI: https://doi.org/10.1007/978-1-4684-2943-5_1

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