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The Use of Snake Venoms as Pharmacological Tools in Studying Nerve Activity

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Neuropoisons

Abstract

Most texts and review articles on venoms have been primarily concerned with chemical properties or mechanisms of action (Bücherl et al., 1968; Jiménez-Porras, 1968; Devi, 1968; Sarkar and Devi, 1968; Russell, 1967; Russell and Saunders, 1967; Condrea and de Vries, 1965; Meldrum, 1965; Braganca and Aravindakshan, 1962; Buckley and Porges, 1956; Zeller, 1951). Indeed, understanding of the pharmacological actions of venoms was greatly aided by the study of their effects on various organ systems such as nerve, muscle, and blood. It was, however, not so readily apparent that this complex, specialized saliva of snakes could be used as a tool for analysis of physiological processes. For example, by 1963 about 6000 papers on snake venoms and venomous snakes had been published (Russell and Scharf-fenberg, 1964), with relatively few of these having as their direct concern a better understanding of the physiological processes affected by venoms. A notable exception was the process of blood coagulation, which has been clarified by studying the action of snake venoms or venom components (Jimenez-Porras, 1968; Condrea and DeVries, 1965; Boquet, 1964). Snake venoms have also been useful as tools in general biochemical research, where the primary interest has been in extracting and studying enzymes obtained from venoms (Zeller, 1966).

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References

  • Adams, R. D. and E. P. Richardson (1961), The demyelinating diseases of the human nervous system, in “Chemical Pathology of the Nervous System” (J. Folch-Pi, ed.) Pergamon Press, New York, pp. 162–194.

    Google Scholar 

  • Angeletti, P. U., P. Calissano, J. S. Chen, and R. Levi-Montalcini (1967), Biochim. Biophys. Acta, 147:180.

    PubMed  CAS  Google Scholar 

  • Beiler, J. M., R. Brendel, and G. J. Martin (1956), J. Pharmacol Exp. Therap., 118:415.

    CAS  Google Scholar 

  • Birkmayer, W. and E. Neumayer (1957), Deut. Z. Nervenheilk, 177:117.

    CAS  Google Scholar 

  • Boquet, P. (1964), Toxicon, 2:5.

    Google Scholar 

  • Braganca, B. M. and I. Aravindakshan (1962), Neurochemical effects of snake venoms, in “Neurochemistry” (A. C. Elliott, I. H. Page, and J. H. Quastel, eds.), Charles C. Thomas, Springfield, Ill., pp. 840–850.

    Google Scholar 

  • Braganca, B. M. and J. H. Quastel (1952), Nature, 169:695.

    PubMed  CAS  Google Scholar 

  • Braganca, B. M. and J. H. Quastel (1953), Biochem. J., 53:88.

    PubMed  CAS  Google Scholar 

  • Brzin, ML, W.-D. Dettbarn, and P. Rosenberg (1965a), Biochem. Pharmacol., 14:919.

    PubMed  CAS  Google Scholar 

  • Brzin, M., W.-D. Dettbarn, P. Rosenberg, and D. Nachmansohn (1965b), J. Cell Biol., 26:353.

    PubMed  CAS  Google Scholar 

  • Brzin, M., V. M. Tennyson, and P. E. Duffy (1966), J. Cell Biol., 31:215.

    PubMed  CAS  Google Scholar 

  • Bücherl, W., E. E. Buckley, and V. Deulofeu (eds.) (1968), “Venomous Animals and Their Venoms,” vol. 1, Academic Press, New York.

    Google Scholar 

  • Buckley, E. E. and N. Porges (eds.), 1956, “Venoms,” American Association for the Advancement of Science, Washington, D.C.

    Google Scholar 

  • Bullock, T. H., D. Nachmansohn, and M. A. Rothenberg (1946), J. Neurophysiol, 9:9.

    PubMed  CAS  Google Scholar 

  • Chang, C. C. (1960), J. Formosan Med. Ass., 59:315.

    Google Scholar 

  • Chatterjee, A. K. (1949), Indian J. Med. Res., 37:241.

    CAS  Google Scholar 

  • Cohen, S. (1958), A nerve growth promoting protein, in “Chemical Basis of Development,” Johns Hopkins Press, Baltimore, pp. 665–667.

    Google Scholar 

  • Cohen, S. (1959), J. Biol. Chem., 234:1129.

    PubMed  CAS  Google Scholar 

  • Cohen, S. and R. Levi-Montalcini (1956), Proc. Nat. Acad. Sci., 42:571.

    PubMed  CAS  Google Scholar 

  • Condrea, E. and A. de Vries, Toxicon, 2:261.

    Google Scholar 

  • Condrea, E. and P. Rosenberg (1968), Biochim. Acta, 150:271.

    CAS  Google Scholar 

  • Condrea, E., A. de Vries, and J. Mager (1962), Biochim. Biophys. Acta, 58:389.

    PubMed  CAS  Google Scholar 

  • Condrea, E., A. de Vries, and J. Mager (1964), Biochim. Biophys. Acta, 84:60.

    PubMed  CAS  Google Scholar 

  • Condrea, E., Y. Avi-Dor, and J. Mager (1965), Biochim. Biophys. Acta, 110:337.

    PubMed  CAS  Google Scholar 

  • Condrea, E., P. Rosenberg, and W.-D. Dettbarn (1967), Biochim. Biophys. Acta, 135:669.

    PubMed  CAS  Google Scholar 

  • Delezenne, C. and S. Ledebt (1911), C. R. Acad. Sci. (Paris), 152:790.

    CAS  Google Scholar 

  • Delezenne, C. and S. Ledebt (1912), C. R. Acad. Sci. (Paris), 155:1101.

    Google Scholar 

  • Dettbarn, W.-D. (1963), Life Sciences, 12:910.

    PubMed  CAS  Google Scholar 

  • Dettbarn, W.-D. and F. A. Davis (1963), Biochim. Biophys. Acta, 66:397.

    PubMed  CAS  Google Scholar 

  • Dettbarn, W.-D. and F. C. G. Hoskin (1962), Biochim. Biophys. Acta, 62:566.

    PubMed  CAS  Google Scholar 

  • Dettbarn, W.-D. and P. Rosenberg (1962), Biochem. Pharmacol., 11:1025.

    PubMed  CAS  Google Scholar 

  • Dettbarn, W.-D. and P. Rosenberg (1966), J. Gen. Physiol., 50:447.

    PubMed  CAS  Google Scholar 

  • Dettbarn, W.-D., P. Rosenberg, and D. Nachmansohn (1964), Life Sciences, 3:55.

    PubMed  CAS  Google Scholar 

  • Devi, A. (1968), The protein and nonprotein constituents of snake venoms, in “Venomous Animals and Their Venoms” (W. Bücherl, E. E. Buckley, and V. Deulofeu, eds.), Academic Press, New York, pp. 119–165.

    Google Scholar 

  • Eccles, J. C. (1964), “The Physiology of Synapses,” Academic Press, New York.

    Google Scholar 

  • Edwards, S. W. and E. G. Ball (1954), J. Biol. Chem., 209:619.

    PubMed  CAS  Google Scholar 

  • Elliott, W. B., J. M. Augustyn, and C. Gans (1966), Mem. Inst. Butantan Simp. Intern., 33:411.

    CAS  Google Scholar 

  • Feinstein, M. B. (1964), J. Gen. Physiol., 48:357.

    PubMed  CAS  Google Scholar 

  • Fleischer, B., A. Casu, and S. Fleischer (1966), Biochem. Biophys. Res. Comm., 24:189.

    PubMed  CAS  Google Scholar 

  • Gautrelet, J. and E. Corteggiani (1938), C. R. Acad. Sci., 207:465.

    CAS  Google Scholar 

  • Gautrelet, J. and E. Corteggiani (1939), C. R. Soc. Biol., 131:951.

    CAS  Google Scholar 

  • Goldman, D. E. (1964), Biophys. J., 4:167.

    CAS  Google Scholar 

  • Green, D. E. and S. Fleischer (1963), Biochim. Biophys. Acta, 70:554.

    PubMed  CAS  Google Scholar 

  • Habermann, E. (1960), Arch. Exp. Pathol. Pharmak., 238:502.

    CAS  Google Scholar 

  • Habermann, E. and B. Krusche (1962), Biochem. Pharmacol., 11:400.

    PubMed  CAS  Google Scholar 

  • Hadidian, Z. (1956), Proteolytic activity and physiologic and pharmacologic actions of Agkistrodon piscivorus venom, in “Venoms” (E. E. Buckley and N. Porges, eds.) American Association for the Advancement of Science, Washington, D.C., pp. 205–215.

    Google Scholar 

  • Heilbronn, E. (1969), J. Neurochem., 16:627.

    PubMed  CAS  Google Scholar 

  • Hodgkin, A. L. (1964), “The Conduction of the Nerve Impulse,” C. C. Thomas, Springfield, Ill.

    Google Scholar 

  • Hokin, L. E. and M. R. Hokin (1963), The role of phosphatides in active transport with particular reference to sodium transport, in “Proc. First Int. Pharmacol. Meeting,” vol. 4, “Drugs and Membranes” (C. A. M. Hogben, ed.) The Macmillan Co., New York, pp. 23–40.

    Google Scholar 

  • Hoskin, F. C. G. and P. Rosenberg (1964), J. Gen. Physiol., 47:1117.

    PubMed  CAS  Google Scholar 

  • Hoskin, F. C. G. and P. Rosenberg (1965), J. Gen. Physiol., 49:47.

    PubMed  CAS  Google Scholar 

  • Hoskin, F. C. G. and P. Rosenberg (1967), Science, 156:966.

    PubMed  CAS  Google Scholar 

  • Hoskin, F. C. G., P. Rosenberg, and M. Brzin (1966), Proc. Nat. Acad. Sci., 55:1231.

    PubMed  CAS  Google Scholar 

  • Hoskin, F. C. G., L. T. Kremzner, and P. Rosenberg (1969), Biochem. Pharmacol., 18:1727.

    PubMed  CAS  Google Scholar 

  • Hudson, A. J., J. H. Quastel, and P. G. Scholefield (1960), J. Neurochem., 5:177.

    PubMed  CAS  Google Scholar 

  • Hughes, A. (1935), Biochem. J., 29:437.

    PubMed  CAS  Google Scholar 

  • Hunter, W. K. (1909), Proc. R. Soc. Med., 3:105.

    Google Scholar 

  • Ibraham, S. A., H. Saunders, and R. H. S. Thompson (1964), Biochem. J., 93:588.

    Google Scholar 

  • Jiménez-Porras, J. M. (1968), Annual Review of Pharmacology, 8:299.

    PubMed  Google Scholar 

  • Katz, B. (1966), “Nerve, Muscle and Synapse,” McGraw-Hill Book Co., New York.

    Google Scholar 

  • Kellaway, C. H. and H. F. Holden (1932), Aust. J. Exp. Biol. Med. Sci., 10:167.

    CAS  Google Scholar 

  • Kirshmann, Ch., E. Condrea, N. Moav, S. Aloof, and A. de Vries (1964), Arch. Int. Pharmacodyn., 150:372.

    Google Scholar 

  • Klibansky, C., J. Shiloah, and A. de Vries (1964), Biochem. Pharmacol., 13:1107.

    PubMed  CAS  Google Scholar 

  • Lamb, G. and W. K. Hunter (1904), Lancet, 1:20.

    Google Scholar 

  • Lee, C. Y. and C. C. Chang (1966), Mem. Inst. Butantan Simp. Int., 33:555.

    CAS  Google Scholar 

  • Lenard, J. and S. J. Singer (1966), Proc. Nat. Acad. Sci., 56:1828.

    PubMed  CAS  Google Scholar 

  • Lenard, J. and S. J. Singer (1968), Science, 159:738.

    PubMed  CAS  Google Scholar 

  • Levi-Montalcini, R. (1958), Chemical stimulation of nerve growth, in “Chemical Basis of Development” (W. D. McElroy and B. Glass, eds.), Johns Hopkins Press, Baltimore, pp. 646–664.

    Google Scholar 

  • Levi-Montalcini, R. and P. U. Angeletti (1961), Biological properties of a nerve growth promoting protein and its antiserum, in “Regional Neurochemistry” (S. S. Kety and J. Elkes, eds.), Pergamon Press, New York, pp. 362–376.

    Google Scholar 

  • Levi-Montalcini, R. and P. U. Angeletti (1968a), Physiol Rev., 48:534.

    PubMed  CAS  Google Scholar 

  • Levi-Montalcini, R. and P. U. Angeletti (1968b), Biological aspects of the nerve growth factor, in “Ciba Found. Symp. Growth of the Nervous System” (G. E. W. Wolstenholme and M. O’Connor, eds.), Churchill, London, pp. 126–147.

    Google Scholar 

  • Levi-Montalcini, R. and B. Booker (1960a), Proc. Nat. Acad. Sci., 42:373.

    Google Scholar 

  • Levi-Montalcini, R. and B. Booker (1960b), Proc. Nat. Acad. Sci., 42:384.

    Google Scholar 

  • Levi-Montalcini, R. and S. Cohen (1956), Proc. Nat. Sci., 42:695.

    CAS  Google Scholar 

  • Long, C. and M. F. Maguire (1954), Biochem. J., 57:223.

    PubMed  CAS  Google Scholar 

  • Macfarlane, M. G. (1950), Biochem. J., 47:267.

    PubMed  CAS  Google Scholar 

  • Macfarlane, M. G. and B. C. J. G. Knight (1941), Biochem. J., 35:884.

    PubMed  CAS  Google Scholar 

  • Magee, W. L. and R. H. S. Thompson (1960), Biochem. J., 77:526.

    PubMed  CAS  Google Scholar 

  • Martin, R. and P. Rosenberg (1968), J. Cell Biol., 36:341.

    PubMed  CAS  Google Scholar 

  • Meldrum, B. S. (1965), Pharmacol Rev., 17:393.

    PubMed  CAS  Google Scholar 

  • Minton, S. A. (1956), Some properties of North American pit viper venoms and their correlation with phylogeny, in “Venoms” (E. E. Buckley and N. Porges, eds.), American Association for the Advancement of Science, Washington, D.C., pp. 145–151.

    Google Scholar 

  • Morazain, R. and P. Rosenberg (1970), Lipid changes in triorthocreasyl phosphate- induced neuropathy, Toxicol. Applied Pharmacol., 16, 461.

    CAS  Google Scholar 

  • Morrison, L. R. and P. C. Zamecnik (1950), Arch. Neurol. Psychiat., 63:367.

    CAS  Google Scholar 

  • Nachmansohn, D. (1959), “Chemical and Molecular Basis of Nerve Activity,” Academic Press, New York.

    Google Scholar 

  • Nachmansohn, D. (1969), J. Gen. Physiol., 54:187s.

    CAS  Google Scholar 

  • Narahashi, T. and J. M. Tobias (1964), Amer. J. Physiol., 207:1441.

    PubMed  CAS  Google Scholar 

  • Nelson, P. G. (1958), J. Cell. Comp. Physiol., 52:127.

    CAS  Google Scholar 

  • Nygaard, A. P. and J. B. Sumner (1953), J. Biol. Chem., 200:723.

    PubMed  CAS  Google Scholar 

  • Nygaard, A. P., M. V. Dianzani, and G. F. Bahr (1954), Exp. Cell. Res., 6:453.

    PubMed  CAS  Google Scholar 

  • Okonogi, T., S. Hoshi, M. Honma, M. Mitsuhashi, S. Maeno, and Y. Sawai (1960), Jap. J. Microbiol, 4:297.

    PubMed  CAS  Google Scholar 

  • Petrushka, E., J. H. Quastel, and P. G. Scholefield (1959), Canad. J. Biochem. Physiol., 37:975.

    PubMed  CAS  Google Scholar 

  • Robertson, J. D. (1963), Unit membranes: a review with recent new studies of experimental alterations and a new subunit structure in synaptic membranes, in “Cellular Membranes in Development” (M. Locke, ed.) Academic Press, New York, p.1.

    Google Scholar 

  • Rosenberg, P. (1960), Biochem. Pharmacol., 3:212.

    PubMed  CAS  Google Scholar 

  • Rosenberg, P. (1965), Toxicon, 3:125.

    PubMed  CAS  Google Scholar 

  • Rosenberg, P. (1966), Mem. Inst. Butantan Simp. Int., 33:477.

    CAS  Google Scholar 

  • Rosenberg, P. (1970), Toxicon, in press.

    Google Scholar 

  • Rosenberg, P. and E. Bartels (1967), J. Pharmacol Exp. Therap., 155:532.

    CAS  Google Scholar 

  • Rosenberg, P. and E. Condrea (1968), Biochem. Pharmacol., 17:2033.

    PubMed  CAS  Google Scholar 

  • Rosenberg, P. and W.-D. Dettbarn (1963), Biochim. Biophys. Acta, 69:103.

    CAS  Google Scholar 

  • Rosenberg, P. and W.-D. Dettbarn (1964), Biochem. Pharmacol., 13:1157.

    PubMed  CAS  Google Scholar 

  • Rosenberg, P. and W.-D. Dettbarn (1967), Use of venoms in testing for essentiality of Cholinesterase in conduction, in “Animal Toxins” (F. E. Russell and P. R. Saunders, eds.), Pergamon Press, New York, pp. 379–388.

    Google Scholar 

  • Rosenberg, P. and S. Ehrenpreis (1961), Biochem. Pharmacol., 8:192.

    PubMed  CAS  Google Scholar 

  • Rosenberg, P. and H. Higman (1960), Biochim. Biophys. Acta, 45:348.

    PubMed  CAS  Google Scholar 

  • Rosenberg, P. and F. C. G. Hoskin (1963), J. Gen. Physiol., 46:1065.

    PubMed  CAS  Google Scholar 

  • Rosenberg, P. and F. C. G. Hoskin (1965), Biochem. Pharmacol., 14:1765.

    PubMed  CAS  Google Scholar 

  • Rosenberg, P. and H. G. Mautner (1967), Science, 155:1569.

    PubMed  CAS  Google Scholar 

  • Rosenberg, P. and K. Y. Ng (1963), Biochim. Biophys. Acta, 75:116.

    PubMed  CAS  Google Scholar 

  • Rosenberg, P. and T. R. Podleski (1962), J. Pharmacol Exp. Therap., 137:249.

    CAS  Google Scholar 

  • Rosenberg, P. and T. R. Podleski (1963), Biochim. Biophys. Acta, 75:104.

    PubMed  CAS  Google Scholar 

  • Rosenberg, P., H. Higman, and D. Nachmansohn (1960), Biochim. Biophys. Acta, 44:151.

    PubMed  CAS  Google Scholar 

  • Rosenberg, P., H. G. Mautner, and D. Nachmansohn (1966), Proc. Nat. Acad. Sci., 55:835.

    PubMed  CAS  Google Scholar 

  • Rossiter, R. J. (1961), The chemistry of wallerian degeneration, in “Chemical Pathology of the Nervous System” (J. Folch-Pi, ed.), Pergamon Press, New York, pp. 207–230.

    Google Scholar 

  • Rothenberg, M. A., D. B. Sprinson, and D. Nachmansohn (1948), J. Neurophysiol. 11:111.

    PubMed  CAS  Google Scholar 

  • Roy, A. C. (1945), Nature, 155:696.

    CAS  Google Scholar 

  • Russell, F. E. (1967), Clin. Pharmacol. Therap., 8:849.

    CAS  Google Scholar 

  • Russell, R. E. and T. E. Long (1961), Effects of venoms on neuromuscular transmission, in “Second International Symp. on Myasthenia gravis,” vol. III (H. R. Viets, ed.), Charles C. Thomas, Springfield, Ill., pp. 101–116.

    Google Scholar 

  • Russell, F. E. and P. R. Saunders (eds.) (1967), “Animal Toxins,” Pergamon Press, New York.

    Google Scholar 

  • Russell, F. E. and R. S. Scharffenberg (1964), “Bibliography of Snake Venoms and Venomous Snakes,” Bibliographic Associates, Inc., West Covina, Calif.

    Google Scholar 

  • Sabatini, M. T., A. P. delraldi, and E. deRobertis (1965), J. Exp. Neurol., 12:370.

    CAS  Google Scholar 

  • Sarkar, N. K. and A. Devi (1968), Enzymes in snake venoms, in “Venomous Animals and Their Venoms” (Bücherl, W., Buckley, E. E., and Deulofeu, V., eds.), vol. 1, Academic Press, New York, pp. 167–216.

    Google Scholar 

  • Sjöstrand, F. X. (1963), The structure and formation of the myelin sheath, in “Mechanisms of Demyelination” (A. S. Rose and C. M. Pearson, eds.), McGraw-Hill, New York, pp. 1–43.

    Google Scholar 

  • Swank, R. L. (1961), “A Biochemical Basis of Multiple Sclerosis,” Charles C. Thomas, Springfield, Ill.

    Google Scholar 

  • Tasaki, I. (1968), “Nerve Excitation. A Macromolecular Approach,” Charles C. Thomas, Springfield, Ill.

    Google Scholar 

  • Thompson, R. H. S. (1964), Lipolytic enzymes and demyelination, in “Metabolism and Physiological Significance of Lipids” (R. M. C. Dawson and E. N. Rhodes, eds.), Wiley & Sons, New York, pp. 541–551.

    Google Scholar 

  • Tobias, J. M. (1955), J. Cell. Comp. Physiol., 46:183.

    CAS  Google Scholar 

  • Tobias, J. M (1958), J. Cell. Comp. Physiol., 52:89.

    CAS  Google Scholar 

  • Tobias, J. M. (1960), J. Gen. Physiol., 43:57.

    PubMed  CAS  Google Scholar 

  • Toman, J. E. P. (1949), Electroenceph. Clin. Neurophysiol, 1:33.

    PubMed  CAS  Google Scholar 

  • Vidal, J. C., B. N. Badano, A. O. M. Stoppani and A. Bovens (1966), Mem. Inst. Butantan Simp. Int., 33:913.

    CAS  Google Scholar 

  • Vidal Breard, J. J. and V. E. Elias (1950), Arch. Farm. Bioquim. Tucman, 5:77.

    Google Scholar 

  • Villegas, G. M. and R. Villegas (1960), J. Ulstrastruct. Res., 3:362.

    CAS  Google Scholar 

  • Wallach, D. F. H. and P. H. Zahler (1966), Proc. Nat. Acad. Sci., 56:1552.

    PubMed  CAS  Google Scholar 

  • Walsh, R. R. and S. E. Deal (1959), Amer. J. Phvsiol., 197:547.

    CAS  Google Scholar 

  • Walsh, R. R. and G. D. Webb (1963), Biochem. Pharmacol., 12:451.

    PubMed  CAS  Google Scholar 

  • Webb, G. D. and H. G. Mautner (1966), Biochem. Pharmacol., 15:2105.

    PubMed  CAS  Google Scholar 

  • Whittaker, V. P. (1961), Biochem. Pharmacol., 5:392.

    PubMed  CAS  Google Scholar 

  • Wilson, I. B. and S. Ginsburg (1955), Biochim. Biophys. Acta., 18:168.

    PubMed  CAS  Google Scholar 

  • Witter, R. F. and M. A. Cottone (1956), Biochim. Biophys. Acta, 22:364.

    PubMed  CAS  Google Scholar 

  • Witter, R. F., A. Morrison, and G. R. Shepardson (1957), Biochim. Biophys. Acta, 26:120.

    PubMed  CAS  Google Scholar 

  • Wooldridge, W. R. and C. Higginbottom (1938), Biochem. J., 32:1718.

    PubMed  CAS  Google Scholar 

  • Zeller, E. A. (1949), Helv. Chim. Acta, 32:94.

    PubMed  CAS  Google Scholar 

  • Zeller, E. A. (1951), Enzymes as essential components of bacterial and animal toxins, in “The Enzymes,” vol. 1, pt. 2 (J. B. Sumner and K. Myrback, eds.), Academic Press, New York, pp. 986–1013.

    Google Scholar 

  • Zeller, E. A. (1966), Mem. Inst. Butantan Simp. Intern., 33:349.

    CAS  Google Scholar 

  • Ziegler, F. D., L. Vázquez-Colón, W. B. Elliott, A. Taub, and C. Gans (1965), Biochemistry, 4:555.

    PubMed  CAS  Google Scholar 

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  1. Division of Pharmacology, School of Pharmacy and Pharmacy Research Institute, The University of Connecticut, Storrs, Connecticut, USA

    Philip Rosenberg

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  1. Laboratory of Chemical Biodynamics, University of California, Berkeley, California, USA

    Lance L. Simpson

  2. Division of Neuroscience, New York State Psychiatric Institute, New York, New York, USA

    Lance L. Simpson

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Rosenberg, P. (1971). The Use of Snake Venoms as Pharmacological Tools in Studying Nerve Activity. In: Simpson, L.L. (eds) Neuropoisons. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2940-4_5

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