The Neuroparalytic and Hemagglutinating Activities of Botulinum Toxin

Simpson, Lance L.

doi:10.1007/978-1-4684-2940-4_14

Lance L. Simpson^3,4

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Abstract

Were any investigator of botulinum toxin asked to describe the poison’s taste, he would indeed be faced with a challenging question. It is unlikely there are surviving witnesses who could testify concerning the taste of toxin. Because the agent is so exceptionally lethal, a quantity sufficient to stimulate the palate would surely be fatal to an unprotected individual or animal. If the approximation of 0.5–5.0 μg toxin per human oral lethal dose is correct (Lamanna and Carr, 1967; Zacks et al., 1968), then a 5-ml volume of ingested fluid need contain only 10^-9 m toxin. A molarity of 10^-9 is several orders of magnitude beneath that needed to stimulate even the most sensitive of taste receptors.

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Laboratory of Chemical Biodynamics, University of California, Berkeley, California, USA
Lance L. Simpson
Division of Neuroscience, New York State Psychiatric Institute, New York, New York, USA
Lance L. Simpson

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Laboratory of Chemical Biodynamics, University of California, Berkeley, California, USA
Lance L. Simpson
Division of Neuroscience, New York State Psychiatric Institute, New York, New York, USA
Lance L. Simpson

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Simpson, L.L. (1971). The Neuroparalytic and Hemagglutinating Activities of Botulinum Toxin. In: Simpson, L.L. (eds) Neuropoisons. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2940-4_14

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DOI: https://doi.org/10.1007/978-1-4684-2940-4_14
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