Tetanus Toxin as a Neuropharmacological Tool

Curtis, D. R.

doi:10.1007/978-1-4684-2940-4_12

D. R. Curtis³

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Abstract

The importance of the toxin of Clostridium tetani as a pharmacological tool is related to the suppression of certain types of central inhibition in vertebrates by both this toxin and strychnine. Although the actions of these substances on inhibitory synaptic transmission are not identical, both appear to affect the same type of synapse, which occurs predominantly in the spinal cord and which for convenience has been classified as “strychnine-sensitive.”

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Department of Physiology, Australian National University, Canberra, Australia
D. R. Curtis

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Laboratory of Chemical Biodynamics, University of California, Berkeley, California, USA
Lance L. Simpson
Division of Neuroscience, New York State Psychiatric Institute, New York, New York, USA
Lance L. Simpson

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Curtis, D.R. (1971). Tetanus Toxin as a Neuropharmacological Tool. In: Simpson, L.L. (eds) Neuropoisons. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2940-4_12

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DOI: https://doi.org/10.1007/978-1-4684-2940-4_12
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