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Prostaglandins in Cellular Biology pp 173–194Cite as

The Role of Prostaglandins in the Immune Response

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Part of the book series: Alza Conference Series ((ALZA,volume 1))

Abstract

Prostaglandins could exert an important influence on the immune response at at least six levels: (1) As a part of the control mechanism which is altered when lymphocytes dedifferentiate and replicate in response to antigen. (2) As short or long range messengers in cell-cell interactions between lymphoid cells. Thus prostaglandins might be involved in the interactions between thymic (T) and bone marrow (B) cells that are required for the full development of cellular and humoral immunity (Hartman, 1971). Or they might participate in the phenomenon of antigenic competition where an ongoing immune response interferes nonspecifically with the effectiveness of an unrelated antigen (Moller, 1971). (3) As regional hormones which might influence the level of differentiation of lymphoid cells in their local environment. Thus, local differences in prostaglandin levels in the thymus and peripheral lymphoid tissues might be involved in thymic cell differentiation in the periphery (Owen & Raff, 1970).

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Authors and Affiliations

  1. Department of Internal Medicine, Washington University Schol of Medicine, St. Louis, Mo., USA

    C. W. Parker

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  1. C. W. Parker
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  1. ALZA Corporation, Palo Alto, California, USA

    Peter W. Ramwell  & Bruce B. Pharriss  & 

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© 1972 Plenum Press, New York

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Parker, C.W. (1972). The Role of Prostaglandins in the Immune Response. In: Ramwell, P.W., Pharriss, B.B. (eds) Prostaglandins in Cellular Biology. Alza Conference Series, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-2844-5_9

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  • DOI: https://doi.org/10.1007/978-1-4684-2844-5_9

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-2846-9

  • Online ISBN: 978-1-4684-2844-5

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