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Prostaglandins in Cellular Biology pp 151–172Cite as

Effect of Prostaglandins upon Enzyme Release from Lysosomes and Experimental Arthritis

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Part of the book series: Alza Conference Series ((ALZA,volume 1))

Abstract

Cells engaged in the uptake of particles become the center of acute inflammatory reactions (Metchnikoff, 1905). This phenomenon has been attributed, in part, to the release from phagocytic cells of enzymes previously sequestered within lysosomes (Weissmann, 1967). Exposure of joints to lysosomal extracts results in inflammation and cartilage degradation (Weissmann et al, 1969). Therefore, inhibition of enzyme release from cells which participate in the inflammatory response may modify the inflammation and subsequent tissue injury.

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Authors and Affiliations

  1. Departments of Medicine, Cell Biology and Genetics, New York University School of Medicine, N. Y., USA

    R. B. Zurier & G. Weissmann

Authors
  1. R. B. Zurier
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  2. G. Weissmann
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Editors and Affiliations

  1. ALZA Corporation, Palo Alto, California, USA

    Peter W. Ramwell  & Bruce B. Pharriss  & 

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© 1972 Plenum Press, New York

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Zurier, R.B., Weissmann, G. (1972). Effect of Prostaglandins upon Enzyme Release from Lysosomes and Experimental Arthritis. In: Ramwell, P.W., Pharriss, B.B. (eds) Prostaglandins in Cellular Biology. Alza Conference Series, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-2844-5_8

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  • DOI: https://doi.org/10.1007/978-1-4684-2844-5_8

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-2846-9

  • Online ISBN: 978-1-4684-2844-5

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