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Use of PGE(1) in Preparation and Storage of Platelet Concentrates

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Part of the book series: Alza Conference Series ((ALZA,volume 1))

Abstract

With increasing awareness by physicians of the usefulness of platelets in treating hemorrhage due to thrombocytopenia, the demand for platelet concentrates has steadily increased. More intensive use of chemotherapy, radiation, and immunosuppressive therapy in modern medicine and the recognition that bleeding may be due to qualitative as well as quantitative platelet abnormalities make it almost certain that the demand for platelets will increase still further. Yet, except within a few institutions, platelets are often in short supply because of their limited permissible storage time and the high cost in time and materials necessary for preparation of a therapeutic quantity of platelets. The finding that platelets can be stored for several days with only minimal loss of viability if kept at room temperature rather than in the cold as was previously recommended, has helped to increase the quantities of platelets available for transfusion (Murphy and Gardner, 1969; Murphy et al, 1970).

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References

  • Aster, R. H., 1969, Effect of acidification in enhancing the viability of platelet concentrates: current status, Vox. Sang. 17:23.

    PubMed  CAS  Google Scholar 

  • Aster, R. H., 1971a, Preparation of platelet concentrates, Vox. Sang., (in press).

    Google Scholar 

  • Aster, R. H., 1971b, The study of platelet kinetics with 51Cr-labeled platelets, in “Platelet Kinetics”, (J. Paulus, R. H. Aster, and M. Breny, eds.). North-Holland Co., Amsterdam, (in press).

    Google Scholar 

  • Aster, R. H., and Jandl, J. H., 1964. Platelet sequestration in man. I. Methods, J. Clin. Invest. 43:843.

    Article  CAS  Google Scholar 

  • Becker, G. A., and Aster, R. H., 1971, Platelet transfusion therapy, Med. Clin. N. Amer., (in press).

    Google Scholar 

  • Born, G. V. R., and Cross, M. J., 1963, The aggregation of blood platelets, J. Physiol. 168:178.

    Article  CAS  Google Scholar 

  • Embrey, M. P., 1971, Induction of abortion by prostaglandins E, J. Reprod. Med. 6:15

    Google Scholar 

  • Emmons, P. R., Hampton, J. R., Harrison, M. J. G., Honour, A. J., and Mitchell, J. R. A., 1967, Effect of prostaglandin E(1) on platelet behaviour in vitro and in vivo, Brit. Med. J. 2:468.

    Article  CAS  Google Scholar 

  • Greiff, D., and Mackey, S., 1970, Cryobiology of platelets. II. Effects of freezing and storage at low temperatures on the survival of isolated human blood platelets as measured by assays for aminopeptidases, Cryobiology 7:9.

    Article  CAS  Google Scholar 

  • Mourad, N., 1968, A simple method for obtaining platelet concentrates free of aggregates, Transfusion 8:48.

    Article  CAS  Google Scholar 

  • Murphy, S., and Gardner, F. H., 1969, Platelet preservation. Effect of storage temperature on maintenance of platelet viability — deleterious effect of refrigerated storage, New Eng. J. Med. 280:1094.

    Article  CAS  Google Scholar 

  • Murphy, S., Sayar, S. N., and Gardner, F. H., 1970, Storage of platelet concentrates at 22°C, Blood 25:549.

    Article  Google Scholar 

  • Shio, H., Plasse, A. M., and Ramwell, P. W., 1970, Platelet swelling and prostaglandins, Microvasc. Res. 2:294.

    Article  CAS  Google Scholar 

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© 1972 Plenum Press, New York

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Becker, G.A., Chalos, M.K., Tuccelli, M., Aster, R.H. (1972). Use of PGE(1) in Preparation and Storage of Platelet Concentrates. In: Ramwell, P.W., Pharriss, B.B. (eds) Prostaglandins in Cellular Biology. Alza Conference Series, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-2844-5_4

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  • DOI: https://doi.org/10.1007/978-1-4684-2844-5_4

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-2846-9

  • Online ISBN: 978-1-4684-2844-5

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