Abstract
Krogh first observed the marked deformation which red cells undergo in their passage through the capillaries (Krogh, 1922). This deformation is imposed upon red cells since non-distensible capillaries have diameters ranging from 3–12 microns whereas that of the red cell averages 8 microns. In order to traverse the smaller capillaries the red cell is deformed into a sausage shape with a cylindrical diameter approximating that of the capillary, but with a length well in excess of its original diameter. This remarkable change in shape occurs without any significant change in surface area (LaCelle, 1970). Red cell membranes are resistant to stretch but quite readily change shape in response to a deforming pressure (Rand and Burton, 1964a, 1964b). In addition to the shape change which takes place in the capillaries, the red cells normally undergo a change in shape in the small arterioles. This deformation occurs in response to the pattern of forces exerted by laminar flow in the arteriolar circulation (Goldsmith, 1970).
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References
Aronson, H. B., Magora, F., and Schenker, J. G., 1971, Effect of oral contraceptives on blood viscosity, Am. J. Obstet. Gynec. 110:997.
Baird, D. T., and Guevara, A., 1969, Concentration of unconjugated estrone and estradiol in peripheral plasma in nonpregnant women throughout the menstrual cycle, castrate and postmenopausal women and in men, J. Clin. Endocrinol, Metab. 29:149.
Braasch, D., and Rogausch, H., 1971, Decreased red-cell deformability after severe burns, determined with the chlor promazine test, Pfluegers Arch. 323:41.
Burton, A. C., 1965, “Physiology and Biophysics of the Circulation,” Year Book Medical Publishers, Chicago.
Goldsmith, H. L., 1970, Motion of particles in a flowing system, Thromb. Diath. Haemmorrh. Suppl. 40:91.
Harrison, D. G., and Long, C., 1968, The calcium content of human erythrocytes, J. Physiol. 199:367.
Krogh, A., 1922, “The Anatomy and Physiology of Capillaries,” Yale University Press, New Haven.
LaCelle, P. L., 1969, Alteration of deformability of the erythrocyte membrane in stored blood, Transf. 9:238.
LaCelle, P. L., 1970, Alteration of membrane deformability in hemolytic anemias, Semin. Hematol. 7:355.
Mela, L., 1968, Interactions of La3+ and local anesthetic drugs with mitochondrial calcium and Mn++ uptake, Arch. Biochem. Biophys. 123:286.
Ponder, E., 1948, “Hemolysis and Related Phenomena,” Grune and Stratton, Inc., New York.
Price-Jones, C., 1920, The diurnal variation in the sizes of red blood cells, J. Path. 23:371.
Ramwell, P. W., and Shaw, J. E., 1970, Biological significance of the prostaglandins, Rec. Prog. Horm. Res. 26:139.
Rand, R. P., and Burton, A. C., 1964a, Mechanical properties of the red cell membrane. I. Membrane stiffness and intracellular pressure, Biophys. J. 4:115.
Rand, R.P., and Burton, A. C., 1964b, Mechanical properties of the red cell membrane. II. Visccelastic breakdown of the membrane, Biophys. J. 4:303.
Teitel, P., 1967, Le test de la filtrabilite erythrocytaire (TFE) une methode simple d’etude de certaines proprietes microrheologigue des globules rouges, Nouv. Rev. Fr. Hematol. 7:195.
Thal, A. P., 1971, “Shock: A Physiologic Basis for Treatment,” Year Book Medical Publishers, Chicago.
Van Breemen, C., 1969, Blockade of membrane calcium fluxes by lanthanum in relation to vascular smooth muscle contractility, Arch. Int. Physiol. 77:710.
Weed, R. I., 1970, The importance of erythrocyte deformability (editorial), Am. J. Med. 49:147.
Weed, R. I., LaCelle, P. L., and Merrill, E. W., 1969, Metabolic dependence of red cell deformability, J. Clin. Invest. 48:795.
Wins, P., and Schoffeniels, E., 1966, ATP and calcium-linked contraction of red cell ghosts, Arch. Int. Physiol. 74:812.
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© 1972 Plenum Press, New York
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Allen, J.E., Rasmussen, H. (1972). Some Effects of Vasoactive Hormones on the Mammalian Red Blood Cell. In: Ramwell, P.W., Pharriss, B.B. (eds) Prostaglandins in Cellular Biology. Alza Conference Series, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-2844-5_3
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DOI: https://doi.org/10.1007/978-1-4684-2844-5_3
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