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The Role of Prostaglandins in the Regulation of Growth and Morphology of Transformed Fibroblasts

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Prostaglandins in Cellular Biology

Part of the book series: Alza Conference Series ((ALZA,volume 1))

Abstract

The use of N6,O2’-dibutyryl 3’,5’-adenosine monophosphate (dbc-AMP) has demonstrated that cyclic AMP regulates several functions of fibroblasts (Table I) (Johnson et al, 1971a and 1971b; Sheppard, 1971; Hsie and Puck, 1971), Since these functions are frequently altered by transformation, the regulation of cyclic AMP metabolism is of obvious inportance to cancer research.

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References

  • Hsie, A., and Puck, T. T., 1971, Morphological transformation of Chinese hamster cells by dibutyryl adenosine cyclic 3’,5’-monophosphate and testosterone, Proc. Nat. Acad. Sci. U.S.A. 68:358.

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  • Johnson, G. S., and Pastan, I., 1971, Prostaglandins alter the growth and morphology of fibroblasts, J. Nat. Cancer Inst. (in press).

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  • Johnson, G. S., Friedman, R. M., and Pastan, I., 1971a, Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells treated with adenosine 3’,5’-cyclic monophosphate and its derivatives, Proc. Nat. Acad. Sci. U.S.A. 68:425.

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  • Johnson, G. S., Friedman, R. M., and Pastan, I., 1971b, Cyclic AMP treated sarcoma cells acquire several morphological characteristics of normal fibroblasts, Ann. N. Y. Acad. Sci. 185:413.

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  • Johnson, G. S., Morgan, W. D., and Pastan, I., 1971c, Regulation of cell motility by cyclic AMP, Nature New Biol. (in press).

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  • Peery, C. V., Johnson, G. S., and Pastan, I., 1971, Adenylate cyclase in normal and tranformed fibroblasts in tissue culture: activation by prostaglandins, J. Biol. Chem. 246:5785.

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  • Sheppard, J. R., 1971, Restoration of contact-inhibited growth in transformed cells by dibutyryl adenosine 3’,5’-cyclic monophosphate, Proc. Nat. Acad. Sci. U.S.A. 68:1316.

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Author information

Authors and Affiliations

  1. Lab. of Molecular Biology, National Cancer Inst., National Institutes of Health, Bethesda, Md., USA

    G. S. Johnson, I. Pastan, C. V. Peery, J. Otten & M. Willingham

Authors
  1. G. S. Johnson
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  2. I. Pastan
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  3. C. V. Peery
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  4. J. Otten
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  5. M. Willingham
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Editor information

Editors and Affiliations

  1. ALZA Corporation, Palo Alto, California, USA

    Peter W. Ramwell  & Bruce B. Pharriss  & 

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© 1972 Plenum Press, New York

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Johnson, G.S., Pastan, I., Peery, C.V., Otten, J., Willingham, M. (1972). The Role of Prostaglandins in the Regulation of Growth and Morphology of Transformed Fibroblasts. In: Ramwell, P.W., Pharriss, B.B. (eds) Prostaglandins in Cellular Biology. Alza Conference Series, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-2844-5_10

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  • DOI: https://doi.org/10.1007/978-1-4684-2844-5_10

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-2846-9

  • Online ISBN: 978-1-4684-2844-5

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