Skip to main content

Abstract

The interstitial fluid bathing the cells must be constantly replenished and readjusted in its composition, since it functions as a source of nutrition for the cells. The circulating blood supplies the means for this adjustment by supporting continuous exchange of fluid and solutes between blood and interstitial fluid in the capillary bed.(1–3) The mechanisms for this action will now be examined.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Selected Reading—Steady State Between Plasma and Interstitial Fluid; Lymph, Edema

  • Rusznyak, I., Földi, M., and Szabó, G., Lymphatics and Lymph Circulation. Physiology and Pathology, 2nd Ed., Pergamon, New York (1968).

    Google Scholar 

  • Mayerson, H. S., Ed., Lymph and the Lymphatic System (Proc. Conf. on Lymph and the Lymphatic System), C. C. Thomas, Springfield, Illinois (1968).

    Google Scholar 

  • McMaster, P. D., Ed., Lymph, Ann. N.Y. Acad. Sci. 46 (8):679–882 (1946)

    Google Scholar 

  • Yoffey, J. M. and Courtice, F. C., Lymphatics, Lymph and Lymphoid Tissue, Harvard Univ. Press, Cambridge, Massachusetts (1956).

    Google Scholar 

  • Moyer, J. H. and Fuchs, M., Ed., Edema, Mechanisms and Management, Saunders, Philadelphia, Pennsylvania (1960).

    Google Scholar 

  • Battezzati, M. and Donini, I., Lymphatic System (translated from Italian), Halsted Press, Wiley, New York (1973).

    Google Scholar 

References

  1. Zweifach, B. W. and Intaglietta, M., Fluid exchange across the blood capillary interface, Fed. Proc. 25: 17841788 (1966).

    Google Scholar 

  2. Burton, A. C., Role of geometry, of size and shape, in the microcirculation, Fed. Proc. 25: 1753–1760 (1966).

    Google Scholar 

  3. Renkin, E. M., Capillary blood flow and transcapillary exchange, Physiologist 9: 361–366 (1966).

    Google Scholar 

  4. Arturson, G., Areskog, N. H., and Arfors, K., The transport of macromolecules across the blood lymph barrier. Influence of capillary pressure on macro-molecular composition of lymph. Bibl. Anat. 10: 228–233 (1969).

    Google Scholar 

  5. Rhodin, J. A. G., The ultrastructure of mammalian arterioles and precapillary sphincters, J. Ultrastruct. Res. 18: 181–223 (1967).

    Article  Google Scholar 

  6. Mellander, S., The regulation of blood flow, Proc. Roy. Soc. Med. 61: 55–61 (1968).

    Google Scholar 

  7. Johnson, P. C. and Wayland, H., Regulation of blood flow in single capillaries, Am. J. Physiol. 212: 1405–1415 (1967).

    Google Scholar 

  8. Starling, E. H., On absorption of fluids from the connective tissue spaces, J. Physiol. 19: 312–326 (1896).

    Google Scholar 

  9. Hyman, C., Physiologic function of the lymphatic system, Cancer Chemotherap. Rep. 58: 25–30 (1969).

    Google Scholar 

  10. Langgard, H., The subcutaneous absorption of albumin in edematous states, Acta Med. Scand. 174: 645–650 (1963).

    Google Scholar 

  11. Threefoot, S. A., Gross and microscopic anatomy of the lymphatic vessels and lymphaticovenous communications, Cancer Chemotherap. Rep. 58:1–20 (1968). 10a.

    Google Scholar 

  12. Lauweryns, J. M., The blood and lymphatic microcirculation of the lung.Pathology Annual 6:365–415 (1971).

    Google Scholar 

  13. Mayerson, H. S., Lymph and Lymphatics, Circulation 28: 839–842 (1963).

    Article  Google Scholar 

  14. Courtice, F. C., Harding, J., and Steinbeck, A. W., The removal of free red blood cells from the peritoneal cavity of animals, Aust. J. Exp. Biol. Med. Sci. 31: 215–225 (1953).

    Article  Google Scholar 

  15. McMaster, P. D., Conditions in the skin influencing interstitial fluid movement, lymph formation and lymph flow, Ann. N.Y. Acad. Sci. 46: 743–787 (1946).

    Article  Google Scholar 

  16. Ludwig, J., Linhart, P., and Baggenstoss, A. H., Hepatic lymph drainage in cirrhosis and congestive heart failure, Arch. Pathol. 86: 551–562 (1968).

    Google Scholar 

  17. Bloom, B., Chaikoff, I. L., and Reinhardt, W. O., Intestinal lymph as pathway for transport of absorbed fatty acids of different chain lengths, Am. J. Physiol. 166: 451–455 (1951).

    Google Scholar 

  18. Hellman, L., Frazell, E. L., and Rosenfeld, R. S., Direct measurement of cholesterol absorption via the thoracic duct in man, J. Clin. Invest. 39: 12881294 (1960).

    Google Scholar 

  19. Daniel, P. M., Gale, M., and Pratt, O. E., Hormones and related substances in the lymph leaving four endocrine glands-The testis, ovary, adrenal and thyroid, Lancet 1: 1223–1234 (1963).

    Google Scholar 

  20. Lever, A. F. and Peart, W. S., Renin and angiotensin-like activity in renal lymph, J. Physiol. 160: 548–563 (1962).

    Google Scholar 

  21. Doemling, D. B. and Steggerda, F. R., Stimulation of thoracic duct lymph flow by epinephrine and norepinephrine, Proc. Soc. Exp. Biol. Med. 110: 811–813 (1962).

    Google Scholar 

  22. Werner, B., The biochemical composition of the human thoracic duct lymph, Acta Clin. Scand. 132: 63–76 (1966).

    Google Scholar 

  23. Ianlez, L. E., Guimaraes, F. R., and Sabbaga, E., Biochemical composition of thoracic duct lymph fluid in chronic renal patients, Rev. Hosp. Clin. Fac. Med. S. Paulo 28: 141–146 (1973).

    Google Scholar 

  24. Szabó, G., Gergely, J., and Magyar, Z., Immunoelectrophoretic analysis of the lymph, Experientia 19: 98–99 (1963).

    Article  Google Scholar 

  25. Blomstrand, R., Nilsson, I. M., and Dahlback, O., Coagulation studies on human thoracic duct lymph, Scand. J. Clin. Lab. Invest. 15: 248–254 (1963).

    Article  Google Scholar 

  26. Bartlett, R. H., Falor, W. H., and Zarafonetis, C. J. D., Lipid studies on human lymph and chyle, J. Am. Med. Assoc. 187: 126–127 (1964).

    Article  Google Scholar 

  27. Gersh, I. and Catchpole, H. R., The nature of ground substance of connective tissue, Perspect. Biol. Med. 3: 282–319 (1960).

    Google Scholar 

  28. Seki, K., Yamane, Y., Shinoura, A., Koide, K., Uechi, M., Mori, K., Nagasaki, M., and Yoshitoshi, Y., Experimental and clinical studies on the lymph circulation, Am. Heart. J. 75: 620–629 (1968).

    Article  Google Scholar 

  29. Losowsky, M. S., Alltree, E. M., and Atkinson, M., Plasma colloid osmotic pressure and its relation to protein fractions, Clin. Sci. 22: 249–257 (1962).

    Google Scholar 

  30. Hollander, W., Reilly, P., and Burrows, B. A., Lymphatic flow in human subjects as indicated by the disappearance of 1131 labeled albumin from the subcutaneous tissues, J. Clin. Invest. 35: 713 (1956).

    Article  Google Scholar 

  31. Castell, D. O., Ascites in cirrhosis. Relative importance of portal hypertension and hypoalbuminemia, Am. J. Dig. Dis. 12: 916–922 (1967).

    Article  Google Scholar 

  32. Wolff, H. P., Blaise, B. H., and Düsterdieck, G., Role of aldosterone in edema formation, Ann. N.Y. Acad. Sci. 139: 285–294 (1962).

    Article  Google Scholar 

  33. Van Tongeren, J. H. and Reichert, W. J., Demonstration of protein-losing gastroenteropathy. The quantitative estimation of gastrointestinal protein loss using 61Cr-labeled plasma proteins, Clin. Chim. Acta 14: 42–48 (1966).

    Article  Google Scholar 

  34. Kerr, R. M., Du Bois, J. J., and Holt, P. R., Use of 1251 and 61Cr labeled albumin for the measurement of gastrointestinal and total albumin catabolism, J. Clin. Invest. 46: 2064–2082 (1967).

    Article  Google Scholar 

  35. Dobbins, W. O., Diseases associated with protein losing enteropathy: Electromicroscopic studies of the intestinal mucosa, South. Med. J. 60: 1077–1081 (1967).

    Google Scholar 

  36. Kocen, R. S. and Atkinson, M., Ascites in hypothyroidism, Lancet 1: 527–531 (1963).

    Article  Google Scholar 

  37. Thorn, G. W., Approach to the patient with “idiopathic edema” of “periodic swelling, ” J. Am. Med. Assoc. 206: 333–338 (1968).

    Article  Google Scholar 

  38. Vorburger, C., Pathogenesis of edema, Angiology 19: 362–371 (1968).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1975 Plenum Press, New York

About this chapter

Cite this chapter

Natelson, S., Natelson, E.A. (1975). Mechanisms for Maintenance of a Steady State Between Plasma and Interstitial Fluid. In: Principles of Applied Clinical Chemistry Chemical Background and Medical Applications. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2745-5_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-2745-5_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2747-9

  • Online ISBN: 978-1-4684-2745-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics