Abstract
Radiotherapy and surgery are the two most successful forms of treatment for localized neoplasms, each having a high cure rate in certain sites but a low cure rate in others. If the tumor is accessible and no vital structures are involved, surgery is the treatment of choice. The radiotherapist therefore tends to treat the more inaccessible tumors, or those with vital structures in close juxtaposition. Both surgery and radiotherapy are treatments of localized disease. Systemic chemotherapy is the main method of treatment for widely disseminated cancer, but whole-body or regional irradiation is sometimes used prophylactically, for example, in leukemia (brain) or osteosarcoma (lungs). Hyperthermia is also being used more extensively.
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Fowler, J.F., Denekamp, J. (1977). Radiation Effects on Normal Tissues. In: Becker, F.F. (eds) Radiotherapy, Surgery, and Immunotherapy. Cancer, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2739-4_5
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