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Radiotherapy, Surgery, and Immunotherapy pp 51–99Cite as

Molecular and Cellular Biology of Radiation Lethality

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Part of the book series: Cancer ((C,volume 6))

Abstract

In the therapy of tumors with radiation and other cytotoxic agents, a primary objective is the differential killing of tumor cells relative to normal cells. Over the years, empirical approaches have had some success; no doubt, some additional widening of the margin between tumor and normal tissue damage can be expected from trial and error. Ultimately, to be able further to improve treatment modes, or to be able to conclude that a given mode has been optimized, a fundamental knowledge of the molecular biology of cell killing is needed.

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Authors and Affiliations

  1. Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois, 60439, USA

    M. M. Elkind

  2. Departments of Medical Physics and Radiation Oncology, Michael Reese Medical Center, Chicago, Illinois, 60616, USA

    J. L. Redpath

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  1. M. M. Elkind
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  1. M. D. Anderson Hospital and Tumor Institute, University of Texas System Cancer Center, Houston, Texas, USA

    Frederick F. Becker

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Elkind, M.M., Redpath, J.L. (1977). Molecular and Cellular Biology of Radiation Lethality. In: Becker, F.F. (eds) Radiotherapy, Surgery, and Immunotherapy. Cancer, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2739-4_3

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  • DOI: https://doi.org/10.1007/978-1-4684-2739-4_3

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