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Biology of Brain Dysfunction pp 229–263Cite as

Disorders of Cerebrospinal Fluid and Brain Extracellular Fluid

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Abstract

The chemical composition of the extracellular fluid (ECF) of the brain is similar to that of cerebrospinal fluid (CSF). Brain ECF is inaccessible for studies in humans, and serial determinations are difficult in animals. On the other hand, CSF can be sampled serially, in vivo, without altering physical or chemical parameters. Therefore, the CSF’s dynamic alterations are used to define dysfunction within the CSF compartment, as a direct index of dysfunction of brain ECF, and as an indirect index of cerebrocellular metabolism and dysfunction.

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Authors and Affiliations

  1. Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Leon D. Prockop

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  1. New York State Institute for Basic Research in Mental Retardation, Staten Island, New York, USA

    Gerald E. Gaull

  2. Mt. Sinai School of Medicine of the City University of New York, New York, New York, USA

    Gerald E. Gaull

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Prockop, L.D. (1973). Disorders of Cerebrospinal Fluid and Brain Extracellular Fluid. In: Gaull, G.E. (eds) Biology of Brain Dysfunction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2667-0_6

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  • DOI: https://doi.org/10.1007/978-1-4684-2667-0_6

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