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Disorders of Glucose Metabolism in Brain Dysfunction

  • Chapter
Biology of Brain Dysfunction

Abstract

The brain is unique among the organs of the body in that it consumes about 50 ml of oxygen per minute (a value representing almost 20% of the resting human’s total requirements) and in that it “extracts” from blood about 70 mg of glucose per minute. Furthermore, experiments have demonstrated the brain’s utter dependence on oxygen and glucose, with irreparable damage resulting from deprivation of either or both for only short periods of time. A causal relationship between altered glucose metabolism and mental disturbances is implied. In this chapter, the association of both systemic and cerebral disorders of glucose metabolism with brain dysfunction will be discussed, with emphasis on in vivo investigations with human subjects and animals.

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  1. Research Center, Rockland State Hospital, Orangeburg, New York, USA

    William Sacks

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  1. New York State Institute for Basic Research in Mental Retardation, Staten Island, New York, USA

    Gerald E. Gaull

  2. Mt. Sinai School of Medicine of the City University of New York, New York, New York, USA

    Gerald E. Gaull

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Sacks, W. (1973). Disorders of Glucose Metabolism in Brain Dysfunction. In: Gaull, G.E. (eds) Biology of Brain Dysfunction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2667-0_4

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