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The Enzymes of Biological Membranes pp 31–55Cite as

The Bacterial Phosphoenolpyruvate Phosphotransferase System

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Abstract

Translocation of certain carbohydrates (monosaccharides and disaccharides) across the cytoplasmic membranes of bacteria can occur by two major processes. These processes are distinguished by the nature of the primary energy source involved as well as the actual mechanism by which the translocation proceeds. The two systems are schematically shown in Figure 1 and can be described in the following manner:

  • Active transport. Systems of this type accumulate the solute in an unaltered form in the cytoplasm. The energy for the translocation is primarily derived from an energized membrane state (membrane potential or proton-motive force derived from electron transport or ATP hydrolysis).

  • Group translocation. This differs thermodynamically from “active transport” since the solute is accumulated in the cytoplasm in a derivatized form. Group translocation has so far been associated only with the translocation of sugars; these are accumulated in the form of phosphate esters. The mechanism responsible for this form of translocation is the phosphotransferase system (Figure 2) which uses phosphoenolpyruvate as its primary source of energy.

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Authors and Affiliations

  1. Department of Biology and The McCollum-Pratt Institute, The Johns Hopkins University, Baltimore, Maryland, 21218, USA

    Werner Kundig

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  1. Werner Kundig
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  1. Department of Biochemistry School of Medicine, Saint Louis University, USA

    Anthony Martonosi

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© 1976 Plenum Press, New York

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Kundig, W. (1976). The Bacterial Phosphoenolpyruvate Phosphotransferase System. In: Martonosi, A. (eds) The Enzymes of Biological Membranes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2658-8_2

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  • DOI: https://doi.org/10.1007/978-1-4684-2658-8_2

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