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Plasma Membrane Calcium Transport and Membrane-Bound Enzymes

  • Chapter
The Enzymes of Biological Membranes

Abstract

This chapter will consider evidence demonstrating the existence in the plasma membrane of an active transport system for calcium. (The terms calcium and Ca are used here to denote calcium in general, including bound calcium and, possibly, free ionized calcium. When free ionized calcium is meant, the symbol Ca2+ will be employed.) Evidence gained mainly from studies using the human red blood cell (RBC) will be reviewed. Reference and inference to calcium transport in other plasma membranes will be made where this seems justified. The relationship of plasma membrane calcium transport to several membrane-bound enzymes will be discussed, consideration of the potential significance of plasma membrane transport to cellular biology will be undertaken, and the possible role of plasma membrane calcium transport in several diseases will be considered. We shall attempt to critically assess the evidence for plasma membrane calcium transport and will attempt to show that transport of calcium in the RBC plasma membrane is representative of most cellular plasma membranes. While not necessarily comprehensive this approach reflects our desire to bridge the gap between basic biochemistry-biophysics and clinical medicine.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, School of Pharmacy and Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington, 98195, USA

    Frank F. Vincenzi

  2. Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington, 98195, USA

    Thomas R. Hinds

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  1. Frank F. Vincenzi
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  2. Thomas R. Hinds
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  1. Department of Biochemistry School of Medicine, Saint Louis University, USA

    Anthony Martonosi

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© 1976 Plenum Press, New York

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Vincenzi, F.F., Hinds, T.R. (1976). Plasma Membrane Calcium Transport and Membrane-Bound Enzymes. In: Martonosi, A. (eds) The Enzymes of Biological Membranes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2658-8_10

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  • DOI: https://doi.org/10.1007/978-1-4684-2658-8_10

  • Publisher Name: Springer, Boston, MA

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