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Behavioral Pharmacology pp 45–60Cite as

Behavioral functions of narcotic antagonists: response-drug contingencies

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Part of the book series: FASEB Monographs ((FASEBM,volume 4))

Abstract

Behavioral effects of the narcotic antagonist naloxone are discussed in terms of stimulus functions. As an eliciting stimulus, the effects of naloxone depend on prior administration of narcotic. Administered independently of responding, naloxone can increase or decrease rates of narcotic-reinforced responding depending on the dose of naloxone. When naloxone is administered as a consequence of narcotic self-injection, the future probability of that behavior is reduced; thus, naloxone can function as a punishing stimulus. As a negatively-reinforcing stimulus, naloxone can maintain behavior which germinates or prevents delivery in morphine-dependent monkeys. In animals with previous naloxone avoidance-escape experience, unavoidable-inescapable injections of naloxone produce increases in avoidance-escape response rates. In these animals, responding subsequently can be maintained, at least temporarily, when naloxone is administered only as the consequence of responding.—Woods, J. H., D. A. Downs and J. Carney. Behavioral functions of narcotic antagonists: response-drug contingencies. Federation Proc. 34: 17771784, 1975.

Supported by Public Health Service Grants DA 00154, DA 00254, and GM 00198.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, 48104, USA

    James H. Woods, David A. Downs & John Carney

Authors
  1. James H. Woods
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  2. David A. Downs
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  3. John Carney
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Editor information

Editors and Affiliations

  1. University of Rochester School of Medicine and Dentistry, USA

    Bernard Weiss  & Victor G. Laties  & 

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© 1975 Springer Science+Business Media New York

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Woods, J.H., Downs, D.A., Carney, J. (1975). Behavioral functions of narcotic antagonists: response-drug contingencies. In: Weiss, B., Laties, V.G. (eds) Behavioral Pharmacology. FASEB Monographs, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2634-2_5

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  • DOI: https://doi.org/10.1007/978-1-4684-2634-2_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2636-6

  • Online ISBN: 978-1-4684-2634-2

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