Abstract
Key-press responding of squirrel monkeys produced intravenous injections of cocaine under two simple types of schedule. Under a fixed-ratio schedule, every 30th response produced an injection; steady responding at high rates of over one per second were maintained during each fixed-ratio component. Under a fixed-interval schedule, the first response occurring after a fixed time of 5 min produced an injection; there was a pause at the start of each interval and then progressively increasing responding until cocaine was injected at the end of the interval. Both squirrel monkeys and rhesus monkeys also were studied under second-order schedules of drug injection. Under one type of second-order schedule, studied only in squirrel monkeys, completion of each fixed-interval component produced only a 2-sec light; completion of the 10th fixed-interval component produced the brief light and an intravenous injection of cocaine. Under a second type of second-order schedule, each fixed-ratio component completed during a fixed time interval (5 or 60 min) produced only a 2-sec light; the first fixed-ratio component completed after the interval of time elapsed produced the brief light and an intravenous (squirrel monkeys) or intramuscular (rhesus monkeys) injection of cocaine. Under both types of second-order schedules, repeated sequences of responding were maintained during each session and characteristic fixed-interval or fixed-ratio patterns of responding were controlled by the brief visual stimuli.—Goldberg, S. R., R. T. Kelleher AND W. H. Morkse. Second-order schedules of drug injection. Federation Proc. 34: 1771–1776, 1975.
Preparation of this manuscript was supported by Public Health Service Research Grants DA-00499, MH-02094, MH-07658 and Research Career Program Award 1-K5- MH22589 (R.T.K.) with facilities and services furnished by the New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts (Public Health Service Grant RR-00168, Division of Research Resources, National Institutes of Health).
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Goldberg, S.R., Kelleher, R.T., Morse, W.H. (1975). Second-order schedules of drug injection. In: Weiss, B., Laties, V.G. (eds) Behavioral Pharmacology. FASEB Monographs, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2634-2_4
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