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Behavioral Pharmacology pp 181–194Cite as

Amphetamine toxicity: behavioral and neuropathological indexes

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Part of the book series: FASEB Monographs ((FASEBM,volume 4))

Abstract

Toxicology, a science that “deals with poisons and their effects” (43), has traditionally emphasized the identification and analysis of chemicals that interfere with life processes. As techniques became more sophisticated, evaluation of morphological lesions came within the province of toxicologists. Only recently, however, has the possibility of correlating function and morphology been suggested to the student in toxicology (e.g., 42); he has been instructed to critically evaluate chemically induced physiological, biochemical and morphological changes. The indexes of toxicity have usually been alterations in blood and urine chemistry, body temperature, and the like. Many of these physiological changes may be the effect of irreversible morphological pathology, and therefore, in fact, indicative of life-threatening toxicity. These irreversible changes represent an end point in the development of overt indications of toxicity. It is of the utmost importance to be able to detect less obvious, but still destructive damage. What is needed are a series of sensitive measures that might, together or separately, indicate the presence of a potentially poisonous substance.

Supported by Public Health Service Grant DA-00085 (W. Richter, Principal Investigator).

C. R. Schuster is the recipient of Career Award MH-11,042.

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Authors and Affiliations

  1. Department of Psychiatry, University of Chicago Pritzker School of Medicine, Chicago, Illinois, 60637, USA

    Charles R. Schuster & Marian W. Fischman

  2. Department of Pharmacological and Physiological Sciences, University of Chicago Pritzker School of Medicine, Chicago, Illinois, 60637, USA

    Charles R. Schuster & Marian W. Fischman

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  1. Charles R. Schuster
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  2. Marian W. Fischman
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Editors and Affiliations

  1. University of Rochester School of Medicine and Dentistry, USA

    Bernard Weiss  & Victor G. Laties  & 

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Schuster, C.R., Fischman, M.W. (1975). Amphetamine toxicity: behavioral and neuropathological indexes. In: Weiss, B., Laties, V.G. (eds) Behavioral Pharmacology. FASEB Monographs, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2634-2_14

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  • DOI: https://doi.org/10.1007/978-1-4684-2634-2_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2636-6

  • Online ISBN: 978-1-4684-2634-2

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