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l-Asparaginase as a Model for Enzyme Therapy of Substrate-Dependent Tumors

  • Chapter
Biomedical Applications of Immobilized Enzymes and Proteins

Abstract

A great deal of work is being carried out using l-asparaginase as a model system for the “selective nutritional deprivation” approach to cancer therapy. Certain tumor cells, unlike normal cells, cannot synthesize enough asparagine and depend on extracellular supplies for asparagine. Selective depletion of this extracellular source of asparagine by l-asparaginase can lead to the suppression of asparagine-dependent tumors.

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Authors and Affiliations

  1. Department of Physiology, McGill University, Montreal, Canada

    E. D. Siu Chong

  2. Departments of Physiology and Medicine, McGill University, Montreal, Canada

    T. M. S. Chang

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  1. E. D. Siu Chong
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  1. Medical Research Council of Canada, Artificial Organs Research Unit, McGill University, Montreal, Quebec, Canada

    Thomas Ming Swi Chang M.D., PH.D., F.R.C.P.(C) (Professor of Physiology, Professor of Medicine, Associate, Director) (Professor of Physiology, Professor of Medicine, Associate, Director)

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© 1977 Plenum Press, New York

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Chong, E.D.S., Chang, T.M.S. (1977). l-Asparaginase as a Model for Enzyme Therapy of Substrate-Dependent Tumors. In: Chang, T.M.S. (eds) Biomedical Applications of Immobilized Enzymes and Proteins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2610-6_9

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  • DOI: https://doi.org/10.1007/978-1-4684-2610-6_9

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