Skip to main content
SpringerLink
Log in
Book cover

Biomedical Applications of Immobilized Enzymes and Proteins pp 329–349Cite as

Some in Vivo and in Vitro Studies of Biologically Active Molecules on Organic Matrixes for Potential Therapeutic Applications

  • Chapter

Abstract

The medical application of an immobilized enzyme or antibody is defined as the use of bound biologically active materials (BBAM) to treat some disease or clinically defined state such as poisoning. The immobilized enzyme or antibody may be used outside the body, ex vivo or extracorporeally, or as an implant in the body, in vivo

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Blackshear, P. L., 1972, Hemolysis at prosthetic surfaces, in: The Chemistry of Biosurfaces( M. L. Hair, ed.), pp. 523–562, Marcel Dekker, Inc., New York.

    Google Scholar 

  • Boucher, R. M. G., 1972, Advances in sterilization techniques; state of the art and recent breakthroughs, Amer. J. Hospital Pharmacy29: 660–672.

    Google Scholar 

  • Cooney, D. A., Weetall, H. H., and Long, E., 1975, Biochemical and pharmacologic properties of Lasparaginase bonded to Dacron vascular prosthesis, Biochem. Pharmacol. 24: 503–515.

    Google Scholar 

  • Enst, R. R., and Doyle, J. E., 1968, Sterilization with gaseous ethylene oxide: a review of chemical and physical factors, Biotechnol. Bioeng. 10: 1–31.

    Article  Google Scholar 

  • Hersh, L. S„ 1974, L-Asparaginase from E. coli II and Erwin. tarot. bound to poly(methyl methacryolate), J. Polymer Sci., Symp. 47: 55–67.

    Google Scholar 

  • Hersh, L. S., Weetall, H. H., and Brown, I. W., 1971, Heparinized polyester fibers, J. Biomed. Mater. Res. Symp. 1: 99–104.

    Google Scholar 

  • Horvath, C., Sardi, A., and Woods, J. S., 1973, L-Asparaginase tubes; kinetic behavior and application in physiological studies, J. Apps. Phyisiol. 34: 181–187.

    Google Scholar 

  • Hyden, H., 1971, An extra-corporeal shunt apparatus for blood detoxification, Arzneimittel-Forschung21: 1671–1675.

    Google Scholar 

  • Ko, R. Y. C., and Hersh, I.. S. 1976, A Dacron wool packed-bed extracorporeal reactor: a kinetic study of immobilized E. coli 11 L-asparaginase, J. Biomed. Mater. Res. 10: 249.

    Article  Google Scholar 

  • Leonard, E. F., and Friedman, L. I., 1970, Thrombogenesis on artificial surfaces: a flow reactor problem, Chem. Eng. Progr. Symp. Ser. 66: 59–71.

    Google Scholar 

  • Mason, R. G., 1973, Blood compatibility of biomaterials: evaluation of a simple screening test, Biomater. Med. Devices and Artificial Organs1: 131–139.

    Google Scholar 

  • Mason, R. G., Scarborough, D. E., Sabina, R. S., Brinkhous, K. M., Ikenberry, L. D., Kearney, J. J., and Clark, H. G., 1969, Thrombogenicity of some biomedical materials: platelet—interface reactions, J. Biomed. Mater. Res. 3: 615–644.

    Article  Google Scholar 

  • Merker, R. L., Eylash, L. J., Mayhew, S. H., and Wang, J. Y. C., 1969, The heparinization of silicone rubber using amino-organo silane coupling agents, Proc. Artificial Heart Conf., 29–39.

    Google Scholar 

  • Merrill, E. W., 1965, Rheology of human blood and some speculations on its role in vascular homeostasis, in: Biophysical Mechanisms in Vascular Homeostasis and Intravascular Thrombosis( P. N. Sawyer, ed.), pp. 121–137, Appleton-Century-Crofts, New York.

    Google Scholar 

  • Nablo, S. V., and Hippie, J. E., 1972, Low energy electron beams for surface sterilization and asceptic practice, Soc. Plastics Eng. Conf, TR-14: 1–19.

    Google Scholar 

  • Plueddemann, E. P., 1970, Adhesion through silane coupling agents, Soc. Plastics Ind., 25th Ann. Tech. Conf, 13-D: 1–10.

    Google Scholar 

  • Sampson, D., Han, T., Hersh, I,. S., and Murphey, G. P., 1974, Extracorporeal chemotheraphy with Lasparaginase in man, J. Surg. Oncol. 6: 39–48.

    Article  Google Scholar 

  • Weetall H. H., 1971, Enzymes immobilized on inorganic carriers by covalent attachment, Res. Develop. 22: 18–22.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research and Development Laboratories, Corning Glass Works, Corning, New York, USA

    L. S. Hersh

  2. Research Works, Corning, New York, USA

    H. H. Weetall

Authors
  1. L. S. Hersh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. H. Weetall
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medical Research Council of Canada, Artificial Organs Research Unit, McGill University, Montreal, Quebec, Canada

    Thomas Ming Swi Chang M.D., PH.D., F.R.C.P.(C) (Professor of Physiology, Professor of Medicine, Associate, Director) (Professor of Physiology, Professor of Medicine, Associate, Director)

Rights and permissions

Reprints and permissions

Copyright information

© 1977 Plenum Press, New York

About this chapter

Cite this chapter

Hersh, L.S., Weetall, H.H. (1977). Some in Vivo and in Vitro Studies of Biologically Active Molecules on Organic Matrixes for Potential Therapeutic Applications. In: Chang, T.M.S. (eds) Biomedical Applications of Immobilized Enzymes and Proteins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2610-6_22

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-2610-6_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2612-0

  • Online ISBN: 978-1-4684-2610-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation