Abstract
The possibility of using enzymes for the treatment of enzyme-deficiency diseases or organ dysfunction has generated enthusiasm over the last 10 years. Part of this enthusiasm has stemmed from technological developments for enzyme stabilization to prolong enzyme activity and for microencapsulation processes to form a protective barrier around the soluble enzyme or stabilized enzyme adduct. The microencapsulated enzyme (adduct) product might then be placed in conjunction with the circulatory system (hemoperfusion), injected intramuscularly, subcutaneously, or intraperitoneally, or administered orally as an ingestible product to carry out its intended functions.
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References
Bricker, N. S., 1964, The functional adaptation of the diseased kidney: I. Glomerular filtration rate, J. Clin. Invest. 43: 1915.
Chang, T. M. S., 1964, Semipermeable aqueous microcapsules, Science 146: 524.
Chang, T. M. S., and Poznansky, M. J., 1968, Semipermeable microcapsules containing catalase for enzyme replacement in acatalosemic mice, Nature 218: 243.
Chang, T. M. S., Johnson, L. J., and Ransom, O., 1967, Semipermeable aqueous microcapsules, Can. J. Physiol. Pharmacol. 45: 705.
Gardner, D. L., Falb, R. D., Kim, B. C., and Emmerling, D. C., 1971, Possible uremic detoxification via oral-ingested microcapsules, Trans. Amer. Soc. Artificial Internal Organs 17: 239.
Gardner, D. L., Emmerling, D. C., Hassler, C. R., and Kim, B. C., 1972, Characterization of nitrogenous metabolites in intestinal fluid of stabilized uremic dogs, Trans. Amer. Soc. Artificial Internal Organs 18 (1): 18.
Gardner, D. L., Emmerling, D.C., Williamson, K. D., Hassler, C. R., and Baytos, W. C., 1973, Combination microcapsule for controlling chronic uremia urea levels, Ann. Conf. Eng. Med. Biol. 26: 267.
Gardner, D. L., Emmerling, D. C., Williamson, K. D., Baytos, W. C., and Hassler, C. R., 1975, Encapsulated adsorbents for removal of nitrogenous metabolites via oral ingestion, Kidney Intern. 7:S-393.
Goldstein, L., and Katchalski, E., 1968, Use of water-insoluble enzyme derivatives in biochemical analysis and separation, Fresenius, J. Anal. Chem. 243: 375.
Haynes, R., and Walsh, K. E., 1969, Enzyme envelopes on colloidal particles, Biochem. Biophys. Res. Commun. 36: 235.
Lowry, D. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., 1951, Protein measurement with the folin phenol reagent, J. Biol. Chem. 193: 265.
Silman, I. H., and Katchalski, E., 1966, Water insoluble derivatives of enzymes, antigens, and antibodies, Ann. Rev. Biochim. 35: 873.
Sparks, R. E., Salemme, R. M., Meier, P. M., Litt, M. H., and Lindan, O., 1969, Removal of waste metabolites in uremia by microencapsulated reactants, Trans. Amer. Soc. Artificial Internal Organs 15: 353.
Weatherburn, N. W., 1967, Phenol-hypochlorite reaction for determination of ammonia, Anal. Chem. 39 (8): 971.
Weetall, H. H., 1970, Storage stability of water insoluble enzymes covalently coupled to organic and inorganic carriers, Biochim. Biophys. Acta 212: 1.
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© 1977 Plenum Press, New York
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Gardner, D.L., Emmerling, D.C. (1977). Stabilized Urease Microencapsulated. In: Chang, T.M.S. (eds) Biomedical Applications of Immobilized Enzymes and Proteins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2610-6_12
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DOI: https://doi.org/10.1007/978-1-4684-2610-6_12
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