Skip to main content
SpringerLink
Log in

The Cellular Actions of Glucocorticoids in Relation to Human Neoplasms

  • Chapter
Steroid Hormone Action and Cancer

Part of the book series: Current Topics in Molecular Endocrinology ((CTME,volume 4))

  • 83 Accesses

Abstract

Two fundamental concepts concerning the actions of steroid hormones seem to be generally agreed upon. The first is that steroids are inducers, inducers of various specific macromolecules in appropriate target cells. To cite but a few examples, in liver and in certain cultured hepatoma cells, glucocorticoids induce increased synthesis of specific enzymes, such as tryptophan oxygenase and tyrosine aminotransferase (1–3). In immature chicks, estrogens provoke growth, as well as increased specific RNA and protein synthesis (ovalbumin) in target cells (4,5). In rat uterus overall increased growth and specific protein synthesis are induced by estrogen (4,5). Dihydrotestosterone induces several enzymes in rat kidney (6), and progesterone induces avidin in estrogen-primed chick oviduct (7). The list is long (8), and the point seems clear. Steroids are inducers of proteins, DNA, and all the various major classes of RNA. Not all effects are seen in all tissues, of course. The differentiated nature of various cell types defines whether they respond at all to steroids, and if so, to which steroids with which responses. The elements responsible for such specificity and differentiation raise the second fundamental concept in steroid hormone action.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Lin, E.C.C. and W.E. Knox, Biochim. Biophys. Acta 26:85, 1957.

    Article  PubMed  CAS  Google Scholar 

  2. Kenney, F.T., J. Biol. Chem. 237:1610, 1962.

    PubMed  CAS  Google Scholar 

  3. Thompson, E.B., G.M. Tonkins and J.F. Curran, Proc. Natl. Acad. Sci., U.S.A. 56:296, 1966.

    Article  PubMed  CAS  Google Scholar 

  4. O’Malley, B.W., New Engl. J. Med. 284:370, 1971.

    Article  PubMed  Google Scholar 

  5. Palmiter, R.D., T. Oka and R.T. Schimke, J. Biol. Chen. 246:724, 1971.

    CAS  Google Scholar 

  6. Paigen, K., R.T. Swank, S. Tornino and R.E. Ganschow, J. Cell Physiol. 85:379, 1975.

    Article  PubMed  CAS  Google Scholar 

  7. Korenman, S.G. and B.W. O’Malley, Endocrinology 83:11, 1968.

    Article  PubMed  CAS  Google Scholar 

  8. Pitot, H.C. and M.B. Yatvin, Physiol. Rev. 53:228, 1973.

    PubMed  CAS  Google Scholar 

  9. Jensen, E.V., S. Mohla, T.A. Gorell and E.R. DeSombre, Vitamins and Hormones 32:89, 1974.

    Article  PubMed  CAS  Google Scholar 

  10. King, R.J.B. and W.I.P. Mainwaring, Steroid-Cell Interactions, Univ. Park Press, Baltimore, 1974, p. 430.

    Google Scholar 

  11. DeSombre, E.R., J.P. Chaband, G.A. Puca and E.V. Jensen, J. Steroid Biochera. 3:445, 1972.

    Article  Google Scholar 

  12. Jensen, E.V., S. Mohla, T. Gorell, S. Tanaka and E.R. De Sombre, J. Steroid Biochem. 3:445, 1972.

    Article  PubMed  CAS  Google Scholar 

  13. Failla, D., G.M. Tomkins and D.V. Santi, Proc. Natl. Acad. Sci., U.S.A. 72:3849, 1975.

    Article  PubMed  CAS  Google Scholar 

  14. Schrader, W.T. and B.W. O’Malley, J. Biol. Chem. 247:51, 1972.

    PubMed  CAS  Google Scholar 

  15. Rousseau, G.G., J.D. Baxter and G.M. Tomkins, J. Mol. Biol. 62:99, 1972.

    Article  Google Scholar 

  16. Pratt, W.B., J.L. Kaine and D.V. Pratt, J. Biol. Chem. 250: 4584, 1975.

    PubMed  CAS  Google Scholar 

  17. Mosher, K.M., D.A. Young and A. Munck, J. Biol. Chem. 246: 654, 1971.

    PubMed  CAS  Google Scholar 

  18. Chan, L., A.R. Means and B.W. O’Malley, Proc. Natl. Acad. Sci., U.S.A. 70:1870, 1973.

    Article  PubMed  CAS  Google Scholar 

  19. Schutz, G., G. Killewich, G. Chen and P. Feigelson, Proc. Natl. Acad. Sci., U.S.A. 72:1017, 1975.

    Article  PubMed  CAS  Google Scholar 

  20. Schwartz, R.J., Nature New Biol. 237:121, 1972.

    PubMed  CAS  Google Scholar 

  21. Makman, M.H., S. Nakagawa and A. White, Rec. Progr. Horm. Res. 23:195, 1967.

    PubMed  CAS  Google Scholar 

  22. Earle, W.R., J. Nat. Cancer Inst. 4:165, 1943.

    CAS  Google Scholar 

  23. Pratt, W.B. and L. Aronow, J. Biol. Chem. 241:5244, 1966.

    PubMed  CAS  Google Scholar 

  24. Henderson, T.C., R.E. Fischel and J.N. Loeb, Endocrinology 88:1471, 1971.

    Article  PubMed  CAS  Google Scholar 

  25. Loeb, J.N, C. Borek and L.L. Yeung, Proc. Natl. Acad. Sci., U.S.A. 70:3852, 1973.

    Article  PubMed  CAS  Google Scholar 

  26. Rosenau, W., J.D. Baxter, G.G. Rousseau and G.M. Tomkins, Nature New Biol. 237:20, 1972.

    Article  PubMed  CAS  Google Scholar 

  27. Kirkpatrick, A.F., R.J. Milholland and F. Rosen, Nature New Biol. 232:216, 1971.

    PubMed  CAS  Google Scholar 

  28. Munck, A.C. Wira, D.A. Young, K.M. Mosher, C. Hallahan and P.A. Bell, J. Steroid Biochem. 3:567, 1972.

    Article  PubMed  CAS  Google Scholar 

  29. Hackney, J.P., S.R. Gross, L. Aronow and W.B. Pratt, Mol. Pharmacol. 6:500, 1970.

    PubMed  CAS  Google Scholar 

  30. Baxter, J.D., A.W. Harris, G.M. Tomkins and M. Cohn, Science 171:189, 1971.

    Article  PubMed  CAS  Google Scholar 

  31. Aronow, L. and J.D. Gabourel, Proc. Soc. Exp. Biol. Med. 111: 348, 1962.

    Google Scholar 

  32. Kirkpatrick, A.F., R.J. Milholland and F. Rosen, Nature New Biol. 232:216, 1971.

    PubMed  CAS  Google Scholar 

  33. Kaiser, N., R.J. Milholland and F. Rosen, Cancer Res. 34: 621, 1974.

    PubMed  CAS  Google Scholar 

  34. Sibley, C.H. and G.M. Tomkins, Cell 2:213, 1974.

    Article  PubMed  CAS  Google Scholar 

  35. Sibley, C.H. and G.M. Tomkins, Cell 2:221, 1974.

    Article  PubMed  CAS  Google Scholar 

  36. Lippman, M.E. and E.B. Thompson, J. Biol. Chem. 249:2483, 1974.

    PubMed  CAS  Google Scholar 

  37. Pratt, W.B. and D.N. Ishii, Biochem. 11:1401, 1972.

    Article  CAS  Google Scholar 

  38. Mosher, K.M., D.A. Young and A. Munck, J. Biol. Chem. 246: 654, 1971.

    PubMed  CAS  Google Scholar 

  39. Makman, M.H, B. Dvorkin and A White, Proc. Natl. Acad, Sci., U.S.A. 68:1269, 1971.

    Article  CAS  Google Scholar 

  40. Makraan, M.H., B. Dvorkin and A. White, J. Biol. Chem. 245: 2556, 1970.

    Google Scholar 

  41. White, A. and M.H. Makman, Adv. Enz. Res. 5:317, 1967.

    Article  CAS  Google Scholar 

  42. Jensen, E.V., G.E. Block, S. Smith, K. Kyser and E.R. DeSombre, Nat. Cancer Inst. Monograph 34 :55, 1971.

    CAS  Google Scholar 

  43. McGuire, W.L., P.P. Carbone and E.P. Vollmer (eds), Estrogen Receptors in Human Breast Cancer, Raven Press, New York, 1975.

    Google Scholar 

  44. Ranney, H. and A. Gellhorn, Amer. J. Med. 22:405, 1957.

    Article  PubMed  CAS  Google Scholar 

  45. Granville, N., F. Rubio Jr., A. Unugur, E. Schulman and W. Dameshek, New Engl. J. Med. 259:207, 1958.

    Article  PubMed  CAS  Google Scholar 

  46. Shanbrom, E. and S. Miller, New Engl. J. Med. 266:1354, 1962.

    Article  PubMed  CAS  Google Scholar 

  47. Henderson, E.S., Semin. Hematol. 6:271, 1969.

    PubMed  CAS  Google Scholar 

  48. Schrek, R., J. Natl. Cancer Inst. 33:837, 1964.

    PubMed  CAS  Google Scholar 

  49. Cline, M.J. and E. Rosenbaum, Cancer Res. 28:2516, 1968.

    PubMed  CAS  Google Scholar 

  50. Cline, M.J., Blood 30:176, 1967.

    PubMed  CAS  Google Scholar 

  51. Werthamer, S. and L. Amaral, Blood 37:463, 1971.

    PubMed  CAS  Google Scholar 

  52. Lippman, M.E., R.H. Halterman, B.G. Leventhal, S. Perry and E.B. Thompson, J. Clin. Invest. 52:1715, 1973.

    Article  PubMed  CAS  Google Scholar 

  53. Lippman, M.E., R. Halterman, S. Perry, B. Leventhal and E.B. Thompson, Nature New Biol. 242:15 7, 1973.

    Google Scholar 

  54. Scatchard, G., Ann. N.Y. Acad. Sci. 51:660, 1949.

    Article  CAS  Google Scholar 

  55. Munck, A. and C. Wira, In: Raspe, G. (ed.), Advances in the Biosciences 7, Schering Workshop on Steroid Hormone Receptors, Pergamon Press, New York, 1971, p. 301.

    Google Scholar 

  56. Claman, H.N., J.W. Moorhead and W.H. Benner, J. Lab. Clin. Med. 78:499, 1971.

    PubMed  CAS  Google Scholar 

  57. Roath, S., M. Israels, J. Wilkinson, Quart. J. Med. 33:257, 1964.

    Google Scholar 

  58. Lippman, M.E., S. Perry and E.B. Thompson, Amer. J. Med. 59: 224, 1975.

    Article  PubMed  CAS  Google Scholar 

  59. Munck, A., Perspect. Biol. Med. 14:265, 1971.

    PubMed  CAS  Google Scholar 

  60. Gailani, S., J. Minowada, P. Silvernail, A. Nussbaum, N. Kaiser, F. Rosen and K. Shimaoka, Cancer Res. 33:2653, 1973.

    PubMed  CAS  Google Scholar 

  61. Yates, F.E., D.J. Marsh and J.W. Maran, In: Mountcastle, (ed.), Medical Physiology, Vol. 2, The C.V. Mosby Co., St. Louis, 1974, p. 1696.

    Google Scholar 

  62. Baumann, G., G. Rappaport, T. Lemarchand-Berand and J. Felber, J. Clin. Endocrinol. Metab. 40:462, 1975.

    Article  PubMed  CAS  Google Scholar 

  63. Kaiser, N., R.J. Milholland and F. Rosen, Cancer Res. 34: 621, 1974.

    PubMed  CAS  Google Scholar 

  64. Yamamoto, K.R., M.R. Stampfer and G.H. Tomkins, Proc. Natl. Acad. Sci., U.S.A. 71:3901, 1974.

    Article  PubMed  CAS  Google Scholar 

  65. Lippman, M.E., S. Perry and E.B. Thompson, Cancer Res. 34: 1572, 1974.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

    E. Brad Thompson

Authors
  1. E. Brad Thompson
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Michigan Medical School, Ann Arbor, Michigan, USA

    K. M. J. Menon

  2. Parke Davis Research Laboratories, Ann Arbor, Michigan, USA

    Jerry R. Reel

Rights and permissions

Reprints and permissions

Copyright information

© 1976 Plenum Press, New York

About this chapter

Cite this chapter

Thompson, E.B. (1976). The Cellular Actions of Glucocorticoids in Relation to Human Neoplasms. In: Menon, K.M.J., Reel, J.R. (eds) Steroid Hormone Action and Cancer. Current Topics in Molecular Endocrinology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2601-4_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-2601-4_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2603-8

  • Online ISBN: 978-1-4684-2601-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation