Studies on Myelin Proteins in Human Peripheral Nerve

  • Keiichi Uyemura
  • Masaru Suzuki
  • Kunio Kitamura
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 100)


The myelin fraction from human peripheral nerve was prepared. Two basic protein fractions (BF-P2 and PB) were isolated from acid extracts of the myelin fraction and three glycoproteins(BR-PO, PASII and Y protein) were purified from its acid-insoluble residue. In biochemical analysis the human BF-P2 protein (M.W.13,000) showed similar but not identical properties to bovine BF-P2 protein. The PB fraction was suggested to include the encephalitogenic CNS-BP (M.W.18,000) and another, new protein of similar molecular weight.

Both the human BR-PO protein (M.W.28,000) and PASII protein (M.W.13,000) showed similar biochemical properties to the corresponding myelin proteins of bovine peripheral nerve, while they both are clearly different from other myelin proteins. Close relationship between the BR-PO protein and the Y protein (M.W.22,000) was suggested by amino acid analysis.

Injection of the myelin fraction of bovine peripheral nerve with the complete adjuvant produced EAN while the CNS-BP induced EAE in laboratory animals. However, all three purified proteins. BF-P2, BR-PO and PASII, from bovine peripheral nerve myelin were inactive in inducing demyelinating diseases.


Amino Acid Composition Myelin Basic Protein Basic Protein Demyelinating Disease Myelin Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviated Heading


Central nervous system


Peripheral nervous system


Encephalitogenic basic protein (M.W.18,000) in CNS myelin


Folch-Lees type proteolipid in CNS myelin


protein — Basic protein (M.W.13,000) in PNS myelin


protein — Glycoprotein (M.W.28,000) in PNS myelin


Protein — Glycoprotein (M.W.13,000) in PNS myelin


Protein — Glycoprotein (M.W.22,000) in PNS myelin


Sodium dodecyl sulfate


Periodic acid-Shiff


Experimental allergic neuritis


Experimental allergic encephalomyelitis


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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Keiichi Uyemura
    • 1
  • Masaru Suzuki
    • 1
  • Kunio Kitamura
    • 1
  1. 1.Department of PhysiologySaitama Medical SchoolMoroyama, Irumagun, SaitamaJapan

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