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Jejunal Viral Antigen in Multiple Sclerosis and Amyotrophic Lateral Sclerosis

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Myelination and Demyelination

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 100))

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Abstract

Statistical data is presented regarding the identification of viral antigen in the jejunum of patients with multiple sclerosis (MS) and other neurological disease, in particular amyotrophic lateral sclerosis (motor neuron disease). The viral antigens were identified using fluorescent antibody techniques previously described (1–3). Jejunal specimens were obtained by conventional passage of a small peroral tube with an attached capsule. The position of the capsule was identified radiographically to be in the proximal jejunum. In some instances, particularly in patients with amyotrophic lateral sclerosis (ALS), impairment of swallowing necessitated the use of a fiber-optic jejunoscope.

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References

  1. Pertschuk, L.P., Cook, A.W. and Gupta, J., Measles antigen in multiple sclerosis: identification in the jejunum by immunofluorescence, Life Sci. 19 (1976) 1603 – 1608.

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  2. Pertschuk, L.P., Cook, A.W., Gupta, J.K., Broome, J.D., Vuletin, J.C., Kim, D.S., Brigati, D.J., Rainford, E.A. and Nidsgorski, F., Jejunal immunopathology in amyotrophie lateral sclerosis and multiple sclerosis, Lancet I (1977) 1119 – 1123.

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  3. Pertschuk, L.P., Cook, A.W., Gupta, J.K., Broome, J.D., Vuletin, J.C., Kim, D.S., Stanek, A.E., Brigati, D.J., Rain-ford, E.A. and Nidsgorski, F., Measles antigen in the jejunum in multiple sclerosis, Lancet II (1977) 300 – 301.

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Author information

Authors and Affiliations

  1. Department of Neuroscience, Long Island College Hospital, and Downstate Medical Center, State University of New York, USA

    Albert W. Cook

  2. Downstate Medical Center, State University of New York, USA

    Louis P. Pertschuk

  3. Department of Medicine, Division of Gastroenterology, Long Island College Hospital, USA

    Jagdish K. Gupta

  4. Downstate Medical Center, State University of New York, Brooklyn, New York, 11203, USA

    Dong S. Kim

Authors
  1. Albert W. Cook
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  2. Louis P. Pertschuk
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  3. Jagdish K. Gupta
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  4. Dong S. Kim
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Editor information

Editors and Affiliations

  1. University of Helsinki, Helsinki, Finland

    Jorma Palo

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© 1978 Plenum Press, New York

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Cook, A.W., Pertschuk, L.P., Gupta, J.K., Kim, D.S. (1978). Jejunal Viral Antigen in Multiple Sclerosis and Amyotrophic Lateral Sclerosis. In: Palo, J. (eds) Myelination and Demyelination. Advances in Experimental Medicine and Biology, vol 100. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2514-7_47

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  • DOI: https://doi.org/10.1007/978-1-4684-2514-7_47

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2516-1

  • Online ISBN: 978-1-4684-2514-7

  • eBook Packages: Springer Book Archive

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