Biochemical Study on Myelin in Adrenoleukodystrophy

  • Tadashi Miyatake
  • Toshio Ariga
  • Tetsushi Atsumi
  • Yoshiaki Komiya
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 100)


Two myelin fractions, heavy and light, were isolated from white matter of a patient with adrenoleukodystrophy. Morphologically, heavy myelin fraction showed compact lamellar structures, and light myelin fraction consisted of loose lamellar structures and rod-like clear space. Analytical studies demonstrated that the chemical composition of heavy myelin fraction was almost the same as that of normal myelin and that light myelin fraction consisted mainly of cholesterol. Long chain saturated fatty acids, C25:0 and C26:0 were increased and C24:1 was decreased in sphingoglycolipids of heavy myelin fraction of the patient.


White Matter Hydroxy Fatty Acid Cerebral White Matter Sucrose Density Gradient Frontal White Matter 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Tadashi Miyatake
    • 1
    • 2
  • Toshio Ariga
    • 2
  • Tetsushi Atsumi
    • 1
  • Yoshiaki Komiya
    • 3
  1. 1.Department of NeurologyJichi Medical SchoolYakushiji, TochigiJapan
  2. 2.Tokyo Metropolitan Institute of Medical ScienceHonkomagome, TokyoJapan
  3. 3.The Biochemical Division, Institute of Brain ResearchFaculty of Medicine, University of TokyoHongo, TokyoJapan

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