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Biochemical Study on Myelin in Adrenoleukodystrophy

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Myelination and Demyelination

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 100))

Summary

Two myelin fractions, heavy and light, were isolated from white matter of a patient with adrenoleukodystrophy. Morphologically, heavy myelin fraction showed compact lamellar structures, and light myelin fraction consisted of loose lamellar structures and rod-like clear space. Analytical studies demonstrated that the chemical composition of heavy myelin fraction was almost the same as that of normal myelin and that light myelin fraction consisted mainly of cholesterol. Long chain saturated fatty acids, C25:0 and C26:0 were increased and C24:1 was decreased in sphingoglycolipids of heavy myelin fraction of the patient.

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Author information

Authors and Affiliations

  1. Department of Neurology, Jichi Medical School, Yakushiji, Tochigi, Japan

    Tadashi Miyatake & Tetsushi Atsumi

  2. Tokyo Metropolitan Institute of Medical Science, Honkomagome, Tokyo, Japan

    Tadashi Miyatake & Toshio Ariga

  3. The Biochemical Division, Institute of Brain Research, Faculty of Medicine, University of Tokyo, Hongo, Tokyo, Japan

    Yoshiaki Komiya

Authors
  1. Tadashi Miyatake
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  2. Toshio Ariga
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  3. Tetsushi Atsumi
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  4. Yoshiaki Komiya
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Editor information

Editors and Affiliations

  1. University of Helsinki, Helsinki, Finland

    Jorma Palo

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© 1978 Plenum Press, New York

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Miyatake, T., Ariga, T., Atsumi, T., Komiya, Y. (1978). Biochemical Study on Myelin in Adrenoleukodystrophy. In: Palo, J. (eds) Myelination and Demyelination. Advances in Experimental Medicine and Biology, vol 100. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2514-7_43

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  • DOI: https://doi.org/10.1007/978-1-4684-2514-7_43

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2516-1

  • Online ISBN: 978-1-4684-2514-7

  • eBook Packages: Springer Book Archive

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