A Search for the “Multiple Sclerosis Virus” — Lack of Effect of Brain Extracts on Myelin Development in Chickens, Mice and Rats
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Attempts were made to transmit possible infectious agents from tissue of MS patients into three animal species, under conditions designed to enhance the development of such an agent. Myelination was monitored by measuring CNPase activity and myelin basic protein. Although no significant effects were observed, the usefulness of a new assay for CNPase was demonstrated. Nude mice were found to have a lower level of CNPase than their heterozygous littermates.
KeywordsMultiple Sclerosis Myelin Basic Protein Cyclic Nucleotide Brain Homogenate Control Material
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- 5.Henle, G.,Koldovsky, U., Henle, W., Ackermann, R. and Haase, G., Multiple sclerosis-associated agent: neutralization of the agent by human sera, Inf. Imm. 12 (1975) 1367–1374.Google Scholar
- 6.Koldovsky, U., Koldovsky, P., Henle, G., Henle, W., Ackermann, R. and Haase, G., Multiple sclerosis-associated agent: transmission to animals and some properties of the agent, Inf. Imm. 12 (1975) 1355–1366.Google Scholar
- 12.Licursi, P.C., Merz, P.A., Merz, G.S. and Carp, R.I., Scrapieinduced changes in the percentage of polymorphonuclear neutrophils in mouse peripheral blood, Inf. Imm. 6 (1972) 370–376.Google Scholar
- 14.Lumsden, C.E., The clinical pathology of multiple sclerosis, in Multiple Sclerosis, a Reappraisal ( D. McAlpine, C.E. Lumsden and E.D. Acheson, eds.) Churchill, Livingstone, Edinburgh (1972) pp. 311–621.Google Scholar
- 18.Riekkinen, P.J., Rinne, U.K., Arstila, A.U., Kurihara, T. and Pelliniemi, T.T., Studies on the pathogenesis of multiple sclerosis: 2’,3’-cyclic nucleotide 3’-phosphohydrolase as marker of demyelination and correlation of findings with lysosomal changes, J. Neurol. Sci. 15 (1972) 113–120.PubMedCrossRefGoogle Scholar
- 20.Rygaard, J., Thymus and self, Immunobiology of the mouse mutant nude (1973) F.A.D.L. Copenhagen.Google Scholar
- 23.Sims,N.R. and Carnegie, P.R., 2’,3’-cyclic nucleotide 3’phosphodiesterase, Advances in Neurochem. 3 (1977) in press.Google Scholar