Abstract
An experimental anticholinergic drug, elantrine, had shown sig nificant improvement in tremor of parkinsonism in 89 patients not taking L-dopa. A double-blind study of 22 parkinsonian patients stabilized on L-dopa showed marked improvement in tremor and moderate improvement in rigidity and bradykinesia when elantrine was added to their treatment program. Nine of 15 patients taking L-dopa (or Sinemet®) and elantrine had cessation of all tremor and have continued free of tremor to date, over two years.
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References
Rix, A., and Fisher, R.G. (1972) Comparison of trihexyphenidyl and dihydromorphanthridine derivative in control of tremor of parkinsonism. South. Med. Journal 65, 1385–1389.
Blonsky, E.R., Ericsson, A.D., McKinney, A.S., Rix, A., Wang, R.I.H., and Rimm, A.A. (1974) Phase II multiclinic study of elantrine in parkinsonism. Clinical Pharmacology and Therapeutics 15 ,46–50.
Hoehn, M.M. and Yahr, M.D. (1967) Parkinsonism: onset, progression and mortality. Neurology 17, 427–442.
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© 1977 Plenum Press, New York
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Rix, A. (1977). Evaluation of an Experimental Anticholinergic Drug, Elantrine, in Treating the Tremor of Parkinsonism. In: Messiha, F.S., Kenny, A.D. (eds) Parkinson’s Disease. Advances in Experimental Medicine and Biology, vol 90. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-2511-6_18
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DOI: https://doi.org/10.1007/978-1-4684-2511-6_18
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