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Historical Aspects and Frontiers of Parkinson’s Disease Research

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Parkinson’s Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 90))

Abstract

From the historical point of view it would appear that right from the beginning of the era that we call modern medicine, drugs have been regarded as important tools in elucidating the biochemi cal pathology of disease. In the history of Parkinson’s disease there has been hardly a drug that has not been tried as a potential remedy. The long list includes such oddities as ferrisulfate, barium chloride, strychnine, metrazol, thyroid and parathyroid hormones, and — surprizingly — striaphorin, an extract of the striatum. Of all the older antiparkinson drugs, anticholinergics attained special significance because of their unquestionable (though low) therapeutic efficacy. However, these drugs also led the thinking of researchers astray because for a long time the effectiveness of the anticholinergic agents was taken as evidence that Parkinson’s disease may be primarily a disorder of cholinergic brain mechanisms.

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Author information

Authors and Affiliations

  1. Institute of Biochemical Pharmacology, University of Vienna, Vienna, Austria

    Oleh Hornykiewicz

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  1. Oleh Hornykiewicz
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Editor information

Editors and Affiliations

  1. Departments of Pharmacology and Therapeutics and Psychiatry, Texas Tech University School of Medicine, Lubbock, Texas, USA

    Fathy S. Messiha Ph. D. (Associate Professor, Chairman) (Associate Professor, Chairman)

  2. Department of Pharmacology and Therapeutics, Tarbox Parkinson’s Disease Institute, Texas Tech University School of Medicine, Lubbock, Texas, USA

    Alexander D. Kenny Ph. D. (Professor and Chairman, Acting Director) (Professor and Chairman, Acting Director)

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© 1977 Plenum Press, New York

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Hornykiewicz, O. (1977). Historical Aspects and Frontiers of Parkinson’s Disease Research. In: Messiha, F.S., Kenny, A.D. (eds) Parkinson’s Disease. Advances in Experimental Medicine and Biology, vol 90. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-2511-6_1

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  • DOI: https://doi.org/10.1007/978-1-4684-2511-6_1

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-2513-0

  • Online ISBN: 978-1-4684-2511-6

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