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Divalent Ion Metabolism

  • Chapter
The Year in Metabolism 1977

Abstract

The regulation of Ca homeostasis involves the precise control of Ca ion level in blood and extracellular fluid (ECF) and maintenance of the structural integrity of the skeleton. Under certain pathological conditions, the homeostatic mechanisms that regulate the Ca level in ECF may do so at the expense of skeletal integrity (e.g., renal osteodystrophy). The principal regulators of Ca include the serum level of inorganic phosphate and several hormones, including parathyroid hormone (PTH), calcitonin (CT), and vitamin D, or its active form, 1,25-dihydroxy-vitamin D3 [1,25(OH)2D3]. The discussion of PTH will be limited to divalent ion control of its secretion, its actions on bone and kidney, and the immunoassay of PTH. A more detailed description of recent developments in PTH research can be found in The Year In Endocrinology 1977, Chapter 4.

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  1. Medical and Research Services, Veterans Administration Wadsworth Hospital Center and Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, California, USA

    Jack W. Coburn & David L. Hartenbower

  2. Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, California, USA

    Charles R. Kleeman

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  1. Center for Endocrinology, Metabolism, and Nutrition, Northwestern University Medical School, Chicago, Illinois, USA

    Norbert Freinkel M. D. (Kettering Professor of Medicine, Professor of Biochemistry, Director) (Kettering Professor of Medicine, Professor of Biochemistry, Director)

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Coburn, J.W., Hartenbower, D.L., Kleeman, C.R. (1978). Divalent Ion Metabolism. In: Freinkel, N. (eds) The Year in Metabolism 1977. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2499-7_9

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