Skip to main content

Disorders of Lipid and Lipoprotein Metabolism

  • Chapter
The Year in Metabolism 1977

Abstract

It is the aim of this chapter to review the major advances that occurred during 1976 with regard to our knowledge about the metabolism of the major plasma lipids and lipoproteins and about clinical abnormalities in lipid transport, with particular emphasis on the hyperlipidemias. The chapter will build on, and in part briefly summarize, the information and ideas reviewed last year (Goodman, 1976), and will also review briefly some other major developments that occurred before 1976 in order to provide important background information.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ahrens, E. H., Jr., 1969, Mass field trials of the diet-heart question: Their significance, timeliness, feasibility, and applicability, Report of the Diet-Heart Panel of the National Heart Institute, Amer. Heart Assoc. Monogr. No. 28, American Heart Association, New York (now Dallas, Texas).

    Google Scholar 

  • Albers, J. J., Cabana, V. G., Warnick, G. R., and Hazzard, W. R., 1975, Lp(a) lipoprotein: Relationship to sinking pre-β lipoprotein, hyperlipoproteinemia, and apolipoprotein B, Metabolism 24:1047–1054.

    Article  PubMed  CAS  Google Scholar 

  • Albers, J. J., Wahl, P. W., Cabana, V. G., Hazzard, W. R., and Hoover, J. J., 1976, Quantitation of apolipoprotein A-I of human plasma high density lipoprotein, Metabolism 25:633–644.

    Article  PubMed  CAS  Google Scholar 

  • Andersen, J. M., and Dietschy, J. M., 1976, Cholesterogenesis: Derepression in extrahepatic tissues with 4-aminopyrazolo[3,4-d]pyrimidine, Science 193:903–905.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, J. T., Grande, F., and Keys, A., 1976, Independence of the effects of cholesterol and degree of saturation of the fat in the diet on serum cholesterol in man, Amer. J. Clin. Nutr. 29:1184–1189.

    PubMed  CAS  Google Scholar 

  • Anderson, R. G. W., Goldstein, J. L., and Brown, M. S., 1976, Localization of low density lipoprotein receptors on plasma membrane of normal human fibroblasts and their absence in cells from a familial hypercholesterolemia homozygote, Proc. Natl. Acad. Sci. U.S.A. 73:2434–2438.

    Article  PubMed  CAS  Google Scholar 

  • Balasubramaniam, S., Goldstein, J. L., Faust, J. R., and Brown, M. S., 1976, Evidence for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in nonhepatic tissues of rat, Proc. Natl. Acad. Sci. U.S.A. 73:2564–2568.

    Article  PubMed  CAS  Google Scholar 

  • Basii, S. K., Goldstein, J. L., Anderson, R. G. W., and Brown, M. S., 1976, Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts, Proc. Natl. Acad. Sci U.S.A. 73:3178–3182.

    Article  Google Scholar 

  • Berg, K., Børresen, A.-L., and Dahlén, G., 1976, Serum-high-density-lipoprotein and atherosclerotic heart-disease, Lancet 1:499–501.

    Article  PubMed  CAS  Google Scholar 

  • Bhattacharyya, A. K., and Connor, W. E., 1974, β-Sitosterolemia and xanthomatosis: A newly described lipid storage disease in two sisters, J. Clin. Invest. 53:1033–1043.

    Article  PubMed  CAS  Google Scholar 

  • Bloch, A., Dinsmore, R. E., and Lees, R. S., 1976, Coronary arteriographic findings in type-II and type-IV hyperlipoproteinaemia, Lancet 1:928–930.

    Article  PubMed  CAS  Google Scholar 

  • Brown, M. S., and Goldstein, J. L., 1976a, Receptor-mediated control of cholesterol metabolism: Study of human mutants has disclosed how cells regulate a substance that is both vital and lethal, Science 191:150–154.

    Article  PubMed  CAS  Google Scholar 

  • Brown, M. S., and Goldstein, J. L., 1976b, Familial hypercholesterolemia: A genetic defect in the low-density lipoprotein receptor, N. Engl. J. Med. 294:1386–1390.

    Article  PubMed  CAS  Google Scholar 

  • Brown, M. S., and Goldstein, J. L., 1976c, Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor-bound low density lipoprotein, Cell 9:663–674.

    Article  PubMed  CAS  Google Scholar 

  • Brown, M. S., Ho, Y. K., and Goldstein, J. L., 1976a, The low-density lipoprotein pathway in human fibroblasts: Relation between cell surface receptor binding and endocytosis of low-density lipoprotein, Ann. N.Y. Acad. Sci. 275:244–257.

    Article  PubMed  CAS  Google Scholar 

  • Brown, M. S., Sobhani, M. K., Brunschede, G. Y., and Goldstein, J. L., 1976b, Restoration of a regulatory response to low density lipoprotein in acid lipase-deficient human fibroblasts,J. Biol. Chem. 251:3277–3286.

    PubMed  CAS  Google Scholar 

  • Brunzell, J. D., Schrott, H. C., Motulsky, A. G., and Bierman, E. L., 1976, Myocardial infarction in the familial forms of hypertriglyceridemia, Metabolism 25:313–320.

    Article  PubMed  CAS  Google Scholar 

  • Buchwald, H., Moore, R. B., and Varco, R. L., 1974a, Ten years clinical experience with partial ileal bypass in management of the hyperlipidemias, Ann. Surg. 180:384–392.

    Article  PubMed  CAS  Google Scholar 

  • Buchwald, H., Moore, R. B., and Varco, R. L., 1974b, Surgical treatment of hyperlipidemia, Circulation 49(Suppl. I): 1–37.

    Google Scholar 

  • Carew, T. E., Hayes, S. B., Koschinsky, T., and Steinberg, D., 1976, A mechanism by which high-density lipoproteins may slow the atherogenic process, Lancet 1:1315–1317.

    Article  PubMed  CAS  Google Scholar 

  • Carlson, L. A., and Böttiger, L. E., 1972, Ischemic heart disease in relation to fasting values of plasma triglycerides and cholesterol, Lancet 1:865–868.

    Article  PubMed  CAS  Google Scholar 

  • Cattran, D. C., Fenton, S. S. A., Wilson, D. R., and Steiner, G., 1976, Defective triglyceride removal in lipemia associated with peritoneal dialysis and haemodialysis, Ann. Intern. Med. 85:29–33.

    PubMed  CAS  Google Scholar 

  • Connor, W. E., and Connor, S. L., 1972, The key role of nutritional factors in the prevention of coronary heart disease, Prev. Med. 1:49–83.

    Article  PubMed  CAS  Google Scholar 

  • Cywes, S., Davies, M. R. Q., Louw, J. H., Berger, G. M. B., Bonnici, F., and Joffe, H. S., 1976, Portacaval shunt in two patients with homozygous type II hyperlipoproteinaemia, S. Afr. Med. J. 50:239–243.

    PubMed  CAS  Google Scholar 

  • Dahlén, G., Berg, K., and Frick, M. H., 1976, Lp(a) lipoprotein, pre-β 1-lipoprotein, serum lipids and atherosclerotic disease, Clin. Genet. 9:558–566.

    Article  PubMed  Google Scholar 

  • Daubresse, J. C., Lerson, G., Plomteux, G., Rorive, G., Luyckx, A. S., and Lefebvre, P. J., 1976, Lipids and lipoproteins in chronic uraemia: A study of the influence of regular haemodialysis, Eur. J. Clin. Invest. 6:159–166.

    Article  PubMed  CAS  Google Scholar 

  • Dawber, T. R., 1973, Risk factors in young adults: The lessons from epidemiologic studies of cardiovascular disease—Framingham, Tecumseh, and Evans County, J. Amer. Coll. Health Assoc. 22:84–95.

    CAS  Google Scholar 

  • Dayton, S., Pearce, M. L., Hashimoto, S., Dixon, W. V., and Tomiyasu, V., 1969, A controlled clinical trial of a diet high in unsaturated fat in preventing complications of atherosclerosis, Circulation 40(Suppl. II): 1–63.

    Google Scholar 

  • Dyer, A. R., 1975, An analysis of the relationship of systolic blood pressure, serum cholesterol, and smoking to 14-year mortality in the Chicago Peoples Gas Company study. I. Total mortality in exponential-Weibull model, J. Chron. Dis. 28:565–570.

    Article  PubMed  CAS  Google Scholar 

  • Eisenberg, S., and Levy, R. I., 1975, Lipoprotein metabolism, in: Advances in Lipid Research, Vol. 13 (R. Paoletti and D. Kritchevsky, eds.) pp. 1–89, Academic Press, New York.

    Google Scholar 

  • Fallat, R. W., and Glueck, C. J., 1976, Familial and acquired type V hyperlipoproteinemia, Atherosclerosis 23:41–62.

    Article  PubMed  CAS  Google Scholar 

  • Fallat, R. W., Glueck, C. J., Lutmer, R., and Mattson, F. H., 1976, Short term study of sucrose polyester, a nonabsorbable fat-like material, as a dietary agent for lowering plasma cholesterol, Amer. J. Clin. Nutr. 29:1204–1215.

    PubMed  CAS  Google Scholar 

  • Farriaux, J.-P., Ribet, M., Bertrand, M., Higgins, M., Mazzuca, M., and Luyckx, A., 1976, Traitement de l’hypercholésterolémie familiale de type II par shunt porto-cave, Arch. Fr. Pediatr. 33:745–759.

    PubMed  CAS  Google Scholar 

  • Frerichs, R. R., Srinivasan, S. R., Webber, L. S., and Berenson, G. S., 1976, Serum cholesterol and triglyceride levels in 3,446 children from a biracial community: The Bogalusa heart study, Circulation 54:302–309.

    PubMed  CAS  Google Scholar 

  • Ganesan, D., Bass, H. B., McConathy, W. J., and Alaupovic, P., 1976, Is decreased activity of C-II activated lipoprotein lipase in type III hyperlipoproteinemia (broad-β-disease) a cause or an effect of increased apolipoprotein E levels?, Metabolism 25:1189–1195.

    Article  PubMed  CAS  Google Scholar 

  • Ginsberg, H., Olefsky, J. M., Kimmerling, G., Crapo, P., and Reaven, G. M., 1976, Induction of hypertriglyceridemia by a low-fat diet, J. Clin. Endocrinol. Metab. 42:729–735.

    Article  CAS  Google Scholar 

  • Glomset, J. A., 1968, The plasma lecithin: cholesterol acyltransferase reaction, J.Lipid Res. 9:155–167.

    CAS  Google Scholar 

  • Glueck, C. J., Fallat, R. W., Millett, F., Gartside, P., Elston, R. C., and Go, R. C. P., 1975, Familial hyper-alpha-lipoproteinemia: Studies in eighteen kindreds, Metabolism 24:1243–1265.

    Article  PubMed  CAS  Google Scholar 

  • Glueck, C. J., Fallat, R. W., Mellies, M. J., and Steiner, P. M., 1976a, Pediatric familial type III hyperlipoproteinemia, Metabolism 25:1269–1274.

    Article  PubMed  CAS  Google Scholar 

  • Glueck, C. J., Gartside, P., Fallat, R. W., Sielski, J., and Steiner, P. M., 1976b, Longevity syndromes: Familial hypobeta and familial hyperalpha lipoproteinemia, J. Lab. Clin. Med. 88:941–957.

    PubMed  CAS  Google Scholar 

  • Glueck, C. J., Mellies, M. J., Srivastava, L., Knowles, H. C. Jr., Fallat, R. W., Tsang, R. G., Wacholder, S., and Buncher, G. R., 1977, Insulin, obesity, and triglyceride interrelationships in sixteen children with familial hypertriglyceridemia, Pediatr. Res. 11:13–18.

    PubMed  CAS  Google Scholar 

  • Goldstein, J. L., and Brown, M. S., 1976, The LDL pathway in human fibroblasts: A receptor-mediated mechanism for the regulation of cholesterol metabolism, in: Current Topics in Cellular Regulation, Vol. II (B. L. Horecker and E. R. Stadtman, eds.) pp. 147–178, Academic Press, New York.

    Google Scholar 

  • Goldstein, J. L., Basu, S. K., Brunschede, G. Y., and Brown, M. S., 1976a, Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans, Cell 7:85–95.

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, J. L., Sobhani, M. K., Faust, J. R., and Brown, M. S., 1976b, Heterozygous familial hypercholesterolemia: Failure of normal allele to compensate for mutant allele at a regulated genetic locus, Cell 9:195–203.

    Article  PubMed  CAS  Google Scholar 

  • Goodman, DeW. S., 1974, Vitamin A transport and retinol-binding protein metabolism, Vitam. Harm. 32:167–180.

    Article  CAS  Google Scholar 

  • Goodman, DeW. S., 1976, Disorders of lipid and lipoprotein metabolism, in: The Year in Metabolism 1975–1976 (N. Freinkel, ed.), pp. 153–180, Plenum Press, New York.

    Chapter  Google Scholar 

  • Goodman, DeW. S., Noble, R. P., and Dell, R. B., 1973, Three-pool model of the long-term turnover of plasma cholesterol in man, J. Lipid Res. 14:178–188.

    PubMed  CAS  Google Scholar 

  • Grundy, S. M., 1975, Effects of polyunsaturated fats on lipid metabolism in patients with hypertriglyceridemia, J. Clin. Invest. 55:269–282.

    Article  PubMed  CAS  Google Scholar 

  • Grundy, S. M., and Ahrens, E. H., Jr., 1969, Measurements of cholesterol turnover, synthesis, and absorption in man, carried out by isotopic kinetic and sterol balance methods, J.Lipid Res. 10:91–107.

    CAS  Google Scholar 

  • Harvengt, C., and Desager, J.-P., 1976, Colestipol in familial type II hyperlipoproteinemia: A three-year trial, Clin. Pharmacol. Ther. 20:310–314.

    PubMed  CAS  Google Scholar 

  • Hazzard, W. R., and Bierman, E. L., 1976, Delayed clearance of chylomicron remnants following vitamin-A-containing oral fat loads in broad-β disease (type III hyperlipoproteinemia), Metabolism 25:777–801.

    Article  PubMed  CAS  Google Scholar 

  • Heiberg, A., 1976, Inheritance of xanthomatosis and hyper-β-lipoproteinaemia: A study of 7 large kindreds, Clin. Genet. 9:92–111.

    Article  PubMed  CAS  Google Scholar 

  • Heiberg, A., and Berg, K., 1976, The inheritance of hyperlipoproteinaemia with xanthomatosis: A study of 132 kindreds, Clin. Genet. 9:203–233.

    Article  PubMed  CAS  Google Scholar 

  • Heinle, R. A., Levy, R. I., Fredrickson, D. S., and Gorlin, R., 1969, lipid and carbohydrate abnormalities in patients with angiographically documented coronary artery disease, Amer. J. Cardiol. 24:178–186.

    Article  PubMed  CAS  Google Scholar 

  • Ho, Y. K., Brown, M. S., Bilheimer, D. W., and Goldstein, J. L., 1976a, Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes, J. Clin. Invest. 58:1465–1474.

    Article  PubMed  CAS  Google Scholar 

  • Ho, Y. K., Brown, M. S., Kayden, H. J., and Goldstein, J. L., 1976b, Binding, internalization, and hydrolysis of low density lipoprotein in long-term lymphoid cell lines from a normal subject and a patient with homozygous familial hypercholesterolemia, J. Exp. Med. 144:444–455.

    Article  PubMed  CAS  Google Scholar 

  • Huttunen, J. K., Ehnholm, C., Kekki, M., and Nikkilä, E. A., 1976, Postheparin plasma lipoprotein lipase and hepatic lipase in normal subjects and in patients with hypertriglyceridaemia: Correlations to sex, age and various parameters of triglyceride metabolism, Clin. Sci. Mol. Med. 50:249–260.

    PubMed  CAS  Google Scholar 

  • Ibels, L. S., Simons, L. A., King, J. O., Williams, P. F., Neale, F. C., and Stewart, J. H., 1975, Studies on the nature and causes of hyperlipidaemia in uraemia, maintenance dialysis and renal transplantation, Q.J. Med. N.S. 44:601–614.

    CAS  Google Scholar 

  • Ibels, L. S., Reardon, M. F., and Nestel, P. J., 1976a, Plasma post-heparin lipolytic activity and triglyceride clearance in uremic and hemodialysis patients and renal allograft recipients, J. Lab. Clin. Med. 87:648–658.

    PubMed  CAS  Google Scholar 

  • Ibels, L. S., Alfrey, A. C., Subryan, V., and Weil, R., III, 1976b, Hyperlipide mia following renal transplantation, Trans. Amer. Soc. Artif. Intern. Organs 22:46–53.

    CAS  Google Scholar 

  • Jackson, R. L., Morrisett, J. D., and Gotto, A. M., Jr., 1976, Lipoprotein structure and metabolism, Physiol. Rev. 56:259–316.

    PubMed  CAS  Google Scholar 

  • Kannel, W. B., Castelli, W. P., Gordon, T., and McNamara, P. M., 1971, Serum cholesterol, lipoproteins, and the risk of coronary heart disease, Ann. Intern. Med. 74:1–12.

    PubMed  CAS  Google Scholar 

  • Keys, A., 1975, Coronary heart disease: The global picture, Atherosclerosis 22:149–192.

    Article  PubMed  CAS  Google Scholar 

  • Kudchodkar, B. J., and Sodhi, H. S., 1976, Turnover of plasma cholesteryl esters and its relationship to other parameters of lipid metabolism in man, Eur. J. Clin. Invest. 6:285–298.

    Article  PubMed  CAS  Google Scholar 

  • Langer, T., Strober, W., and Levy, R. I., 1972, The metabolism of low density lipoprotein in familial type II hyperlipoproteinemia,J. Clin. Invest. 51:1528–1536.

    Article  PubMed  CAS  Google Scholar 

  • Lauer, R. M., Connor, W. E., Leaverton, P. E., Reiter, M. A., and Clarke, W. R., 1975, Coronary heart disease risk factors in school children: The Muscatine study,J. Pediatr. 86:697–706.

    Article  PubMed  CAS  Google Scholar 

  • Leren, P., 1970, The Oslo diet-heart study: Eleven year report, Circulation 42:935–942.

    PubMed  CAS  Google Scholar 

  • Lupien, P.-J., Moorjani, S., and Awad, J., 1976, A new approach to the management of familial hypercholesterolaemia: Removal of plasma-cholesterol based on the principle of affinity chromatography, Lancet 1:1261–1265.

    Article  PubMed  CAS  Google Scholar 

  • Mahley, R. W., Weisgraber, K. H., Innerarity, T., and Brewer, H. B., 1975, Swine lipoproteins and atherosclerosis: Changes in the plasma lipoproteins and apoproteins induced by cholesterol feeding, Biochemistry 14:2817–2823.

    Article  PubMed  CAS  Google Scholar 

  • Mahley, R. W., Weisgraber, K. H., and Innerarity, T., 1976, Atherogenic hyperlipoproteinemia induced by cholesterol feeding in the Patas monkey, Biochemistry 15:2979–2985.

    Article  PubMed  CAS  Google Scholar 

  • Manzato, E., Fellin, R., Baggio, G., Walch, S., Neubeck, W., and Seidel, D., 1976, Formation of lipoprotein-X: Its relationship to bile compounds,J. Clin. Invest. 57:1248–1260.

    Article  PubMed  CAS  Google Scholar 

  • McConathy, W. J., and Alaupovic, P., 1976, Studies on the isolation and partial characterization of apolipoprotein D and lipoprotein D of human plasma, Biochemistry 15:515–520.

    Article  PubMed  CAS  Google Scholar 

  • Miettinen, M., Turpeinen, O., Karvonen, M. J., Elosuo, R., and Paavilainen, E., 1972, Effect of cholesterol-lowering diet on mortality from coronary heart disease and other causes: A twelve year clinical trial in men and women, Lancet 2:835–838.

    Article  PubMed  CAS  Google Scholar 

  • Miller, G. J., and Miller, N. E., 1975, Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease, Lancet 1:16–19.

    Article  PubMed  CAS  Google Scholar 

  • Miller, N. E., Nestel, P. J., and Clifton-Bligh, P., 1976, Relationships between plasma lipoprotein cholesterol concentrations and the pool size and metabolism of cholesterol in man, Atherosclerosis 23:535–547.

    Article  PubMed  CAS  Google Scholar 

  • Motulsky, A. G., 1976, Current concepts in genetics: The genetic hyperlipidemias, N. Engl. J. Med. 294:823–827.

    Article  PubMed  CAS  Google Scholar 

  • Murray, R. G., Tweddel, A., Third, J. L. H. C., Hutton, I., Hillis, W. S., Lorimer, A. R., and Lawrie, T. D. V., 1975, Relation between extent of coronary artery disease and severity of hyperlipoproteinaemia, Br. Heart J. 37:1205–1209.

    Article  PubMed  CAS  Google Scholar 

  • Myant, N. B., Reichl, D., Thompson, G. R., Higgins, M.J. P., and Galton, D. J., 1976, The metabolism in vivo and in vitro of plasma low-density lipoprotein from a subject with inherited hypercholesterolaemia, Clin. Sci. Mol. Med. 51:463–465.

    PubMed  CAS  Google Scholar 

  • Norbeck, H.-E., Orö, L., and Carlson, L. A., 1976, Serum lipid and lipoprotein concentrations in chronic uremia, Acta Med. Scand. 200:487–492.

    Article  PubMed  CAS  Google Scholar 

  • Olefsky, J. M., Crapo, P., and Reaven, G. M., 1976, Postprandial plasma triglyceride and cholesterol responses to a low-fat meal, Amer. J. Clin. Nutr. 29:535–539.

    PubMed  CAS  Google Scholar 

  • Oliver, M. F., Nimmo, I. A., Cooke, M., Carlson, L. A., and Olsson, A. G., 1975, Ischaemic heart disease and associated risk factors in 40 year old men in Edinburgh and Stockholm, Eur. J. Clin. Invest. 5:507–514.

    PubMed  CAS  Google Scholar 

  • Pennisi, A. J., Heuser, E. T., Mickey, M. R., Lipsey, A., Malekzadeh, M. H., and Fine, R. N., 1976, Hyperlipidemia in pediatric hemodialysis and renal transplant patients, Amer. J. Dis. Child. 130:957–961.

    PubMed  CAS  Google Scholar 

  • Rhoads, G. G., Gulbrandsen, C. L., and Kagan, A., 1976, Serum lipoproteins and coronary heart disease in a population study of Hawaii Japanese men, N. Engl. J. Med. 294:293–298.

    Article  PubMed  CAS  Google Scholar 

  • Ritland, S., 1975, Quantitative determination of the abnormal lipoprotein of cholestasis, LP-X, in liver disease, Scand. J. Gastroenterol. 10:5–15.

    PubMed  CAS  Google Scholar 

  • Ross, R., and Glomset, J. A., 1976, The pathogenesis of atherosclerosis, N. Engl. J. Med. 295:369–377, 420–425.

    Article  Google Scholar 

  • Ross, R., and Harker, L., 1976, Hyperlipidemia and atherosclerosis: Chronic hyperlipidemia initiates and maintains lesions by endothelial cell desquamation and lipid accumulation, Science 193:1094–1100.

    Article  PubMed  CAS  Google Scholar 

  • Ryan, J. R., Jain, A. K., and McMahon, F. G., 1975, Long-term treatment of hypercholesterolemia with colestipol hydrochloride, Clin. Pharmacol. Ther. 17:83–87.

    PubMed  CAS  Google Scholar 

  • Salel, A. F., Riggs, K., Mason, D. T., Amsterdam, E. A., and Zelis, R., 1974, The importance of type IV hyperlipoproteinemia as a predisposing factor in coronary artery disease, Amer. J. Med. 57:897–903.

    Article  PubMed  CAS  Google Scholar 

  • Salen, G., and Grundy, S. M., 1973, The metabolism of cholestanol, cholesterol, and bile acids in cerebrotendinous xanthomatosis, J. Clin. Invest. 52:2822–2835.

    Article  PubMed  CAS  Google Scholar 

  • Salen, G., Meriwether, T. W., and Nicolau, G., 1975, Chenodeoxycholic acid inhibits increased cholesterol and cholestanol synthesis in patients wtih cerebrotendinous xanthomatosis, Biochem. Med. 14:57–74.

    Article  PubMed  CAS  Google Scholar 

  • Salen, G., Shefer, S., Zaki, F. G., and Mosbach, E. H., 1977, Inborn errors of bile acid synthesis, Clin. Gastroenterol. 6:91–101.

    PubMed  CAS  Google Scholar 

  • Shulman, R. S., Bhattacharyya, A. K., Connor, W. E., and Fredrickson, D. S., 1976, β-Sitosterolemia and xanthomatosis, N. Engl. J. Med. 294:482–483.

    Article  PubMed  CAS  Google Scholar 

  • Sigler, G. F., Soutar, A. K., Smith, L. C., Gotto, A. M., Jr., and Sparrow, J. T., 1976, The solid phase synthesis of a protein activator for lecithin-cholesterol acyltransferase corresponding to human plasma apoC-I, Proc. Natl. Acad. Sci. U.S.A. 73:1422–1426.

    Article  PubMed  CAS  Google Scholar 

  • Sigurdsson, G., Nicoli, A., and Lewis, B., 1976, Metabolism of very low density lipoproteins in hyperlipidaemia: Studies of apolipoprotein B kinetics in man, Eur. J. Clin. Invest. 6:167–177.

    Article  PubMed  CAS  Google Scholar 

  • Sing, C. F., Chamberlain, M. A., Block, W. D., and Feiler, S., 1975, Analysis of genetic and environmental sources of variation in serum cholesterol in Tecumseh, Michigan. I. Analysis of the frequency distribution for evidence of a genetic polymorphism, Amer. J. Hum. Genet. 27:333–347.

    PubMed  CAS  Google Scholar 

  • Slack, J., 1975, The genetic contribution to coronary heart disease through lipoprotein concentrations, Postgrad. Med. J. 51(SuppI. 8):27–32.

    CAS  Google Scholar 

  • Smith, F. R., Dell, R. B., Noble, R. P., and Goodman, DeW. S., 1976, Parameters of the three-pool model of the turnover of plasma cholesterol in normal and hyperlipidemic humans, J. Clin. Invest. 57:137–148.

    Article  PubMed  CAS  Google Scholar 

  • Sodhi, H. S., and Kudchodkar, B. J., 1973, Synthesis of cholesterol in hypercholesterolemia and its relationship to plasma triglycerides, Metab. (Clin. Exp.) 22:895–912.

    Article  CAS  Google Scholar 

  • Stein, O., and Stein, Y., 1976, High density lipoproteins reduce the uptake of low density lipoproteins by human endothelial cells in culture, Biochim. Biophys. Acta 431:363–368.

    PubMed  CAS  Google Scholar 

  • Thompson, G. R., and Myant, N. B., 1976, Low density lipoprotein turnover in familial hypercholesterolaemia after plasma exchange, Atherosclerosis 23:371–377.

    Article  Google Scholar 

  • Tyroler, H. A., Hames, C. G., Krishan, I., Heyden, S., Cooper, G., and Cassel, J. C., 1975, Black-white differences in serum lipids and lipoproteins in Evans county, Prev. Med. 4:541–549.

    Article  PubMed  CAS  Google Scholar 

  • Walton, K. W., Hitchens, J., Magnani, H. N., and Khan, M., 1974, A study of methods of identification and estimation of LP(a) lipoprotein and of its significance in health, hyperlipidaemia and atherosclerosis, Atherosclerosis 20:323–346.

    Article  PubMed  CAS  Google Scholar 

  • West, R. J., Fosbrooke, A. S., and Lloyd, J. K., 1975, Treatment of children with familial hypercholesterolemia, Postgrad. Med. J. 51(Suppl. 8):82–86.

    CAS  Google Scholar 

  • Witters, L. A., Herbert, P. N., Shulman, R. S., Krauss, R. M., and Levy, R. I., 1976, Therapeutic failure in familial type II hyperlipoproteinemia, Metabolism 25:1017–1026.

    Article  PubMed  CAS  Google Scholar 

  • Wood, P. D., Haskell, W., Klein, H., Lewis, S., Stern, M. P., and Farquhar, J. W., 1976, The distribution of plasma lipoproteins in middle-aged male runners, Metabolism 25:1249–1257.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1978 Plenum Publishing Corporation

About this chapter

Cite this chapter

Goodman, D.S. (1978). Disorders of Lipid and Lipoprotein Metabolism. In: Freinkel, N. (eds) The Year in Metabolism 1977. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2499-7_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-2499-7_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2501-7

  • Online ISBN: 978-1-4684-2499-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics