Abstract
During 1976, there was considerable progress in investigating a number of areas concerned with nutrition and health. Three of these areas will be reviewed in detail:
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1.
Malnutrition and the mechanisms of cellular growth
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2.
Genetic obesity
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3.
Nutrition and pregnancy
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References
Antinmo, T., Baldijão, C., Pond, W. G., and Barnes, R. H., 1976a, Decreased dietary protein or energy intake and plasma growth hormone levels of the pregnant pig, its fetuses and developing progeny, J. Nutr. 106:940.
Antinmo, T., Baldijão, C., Pond, W. G. and Barnes, R. H., 1976b, Maternal protein malnutrition during gestation alone and its effects on plasma insulin levels of the pregnant pig, its fetuses and the developing offspring, J. Nutr. 106:1647.
Bell, G. E., and Stern, J. S., 1976, Development of obesity and hyperinsulinemia in the Zucker obese rat (fa/fa), Fed. Proc. Fed. Amer. Soc. Exp. Biol. 35:657 (abstract).
Björntorp, P., and Sjöström, L., 1971, Number and size of adipose tissue fat cells in relation to metabolism in human obesity, Metabolism 20:703.
Blackwell, R. Q., Chow, B. F., Chin, K. S., Blackwell, B., and Hsu, S. C., 1973, Prospective maternal nutrition study in Taiwan: Rationale, study design, feasibility, and preliminary findings, Nutr. Rep. Int. 7:517.
Börjeson, M., 1976, The aetiology of obesity in children, Acta Paediatr. Scand. 65:279.
Brasel, J. A., 1972, Age dependent differences in DNA polymerase activity following uninephrectomy in rats, Growth 36:45.
Brasel, J. A., Coffey, D. S., and Williams-Ashman, H. G., 1968, Androgen induced changes in DNA polymerase activity of coagulating glands of castrated rats, Med. Exp. 18:321.
Brasel, J. A., Ehrenkranz, R. A., and Winick, M., 1973, Patterns of DNA polymerase activity in normal rat forebrain and cerebellum in the suckling period, Growth 37:301.
Bray, G. A., and York, D. A., 1972, Studies on food intake of genetically obese rats, Amer. J. Physiol. 223:176.
Brook, C. G. D., Lloyd, J. K., and Wolff, O. H., 1972, Relation between age of onset of obesity and size and number of adipose cells, Br. Med. J. 2:25.
Calloway, D. H., 1972, Nitrogen balance during pregnancy, in: Current Concepts in Nutrition, Vol. 2, Nutrition and Fetal Development (M. Winick, ed.), pp. 79–94, John Wiley & Sons, New York.
Charney, E., Goodman, H. C., McBride, M., Lyon, B., and Pratt, R., 1976, Childhood antecedents of adult obesity: Do chubby infants become obese adults?, N. Engl. J. Med. 295:6.
Cleary, M. P., 1976, Postnatal growth and thymidine kinase activity in adipose tissue of normal, genetically obese, and overfed rats, Doctoral dissertation, Columbia University, New York.
Cleary, M. P., Greenwood, M. R. C., and Brasel, J. A., 1975, Thymidine kinase as a measure of adipocyte proliferation in normal and obese rats, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 34:908 (abstract).
Cleary, M. P., Klein, B. E., Greenwood, M. R. C., and Brasel, J. A., 1976, Proliferative enzymes in adipose tissue of normal and obese rats, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 35:502 (abstract).
Cruce, J. A., Thoa, N. B., and Jacobowitz, D. M., 1976, Catecholamines in the brains of genetically obese rats, Brain Res. 101: 165.
Dallman, P. R., 1971, Malnutrition: Incorporation ofthymidine-3H into nuclear and mitochondrial DNA, J. Cell Biol. 51:549.
Dallman, P. R., and Maimes, E. C., 1973, Protein deficiency: Contrasting effects on DNA and RNA metabolism in rat liver, J. Nutr. 103:1311.
Daniel, R. R., Metzger, B. E., Freinkel, N., Faloona, G., Unger, R. H., and Nitzan, M., 1974, Carbohydrate metabolism in pregnancy. XI. Response of plasma glucagon to overnight fast and oral glucose during normal pregnancy and in gestational diabetes, Diabetes 23:771.
Deb, S., Martin, R. J., and Hirschberger, T. V., 1976, Maintenance requirement and energetic efficiency of lean and obese Zucker rats, J. Nutr. 106:191.
Doran, T. A., Malone, R. M., Benzie, R. J., Jones O. V., Thompson, D. W., and New, M. L., 1976, Amniotic fluid tests for fetal maturity in normal and abnormal pregnancies, Amer. J. Obstet. Gynecol. 125:586.
Dörner, G., Hagen, N., and Witthuhn, W., 1976, Die früh postnatale Überernährung als ätiopathogene tischer Faktor der Erwachsenen fettsucht, Acta Biol. Med. Ger. 35:799.
Faust, I. M., Johnson, P. R., and Hirsch, J., 1976, Noncompensation of adipose mass in partially lipectomized mice and rats, Amer. J. Physiol. 231:538.
Freinkel, N., 1965, Effects of the conceptus on maternal metabolism during pregnancy, in: On the Nature and Treatment of Diabetes (B. S. Leibel and G. A. Wrenshall, eds.), pp. 679–691, Excerpta Medica, Amsterdam.
Freinkel, N., and Metzger, B. E., 1975, Some considerations of fuel economy in the fed state during late human pregnancy, in: Early Diabetes in Early Life (R. Camerini and H. Cole, eds.), pp. 289–301, Academic Press, New York.
Freinkel, N., Metzger, B. E., Nitzan, H., Daniel, R., Surmaczynska, B., and Nagel, T., 1974, Facilitated anabolism in late pregnancy: Some novel maternal compensations for accelerated starvation, in: Proceedings of the VIIIth Congress of the International Diabetes Federation, Int. Cong. Ser. 312 (N.J. Malaise and J. Pirant, eds.), pp. 474–488, Excerpta Medica, Amsterdam.
Garn, S. M., 1976, The origins of obesity, Amer. J. Dis. Child. 130:465.
Garn, S. M., and Clark, D. C., 1976, Trends in fatness and the origins of obesity, Pediatrics 57:443.
Goldberg, A. L., and Goldspink, D. P., 1975, Influence of food deprivation and adrenal steroids on DNA synthesis in various mammalian tissues, Amer. J. Physiol. 228:310.
Greenwood, M. R. C., and Hirsch, J., 1974, Postnatal development of adipocyte cellularity in the normal rat, J. Lipid Res. 15:474.
Greenwood, M. R. C., Hirsch, J., Quartermain, D., Johnson, P., and Cruce, J. A. F., 1974, Food motivated behavior in the genetically obese and hypothalamic-hyperphagic rats and mice, Physiol. Behav. 13:687.
Harbhajan, S. P., and Siamak, A. A., 1976, Assessment of effect of starvation, glucose, fatty acids and hormones on α-decarboxylation of leucine in skeletal muscle of rat, J. Nutr. 106:1079.
Harding, H. R., Rosen, F., and Nichol, C. A., 1961, Influence of age, adrenolectomy and corticosteroids on hepatic transaminase activity, Amer. J. Physiol. 201:271.
Herrera, E., and Freinkel, N., 1975, Metabolites in the liver, brain and placenta of fed or fasted mothers and fetal rats, Horm. Metab. Res. 7:247.
Herrera, E., Knopp, R. H., and Freinkel, N., 1969, Carbohydrate metabolism in pregnancy. VI. Plasma fuels, insulin, liver composition, gluconeogenesis and nitrogen metabolism during late gestation in the fed and fasted rat, J. Clin. Invest. 48:2260.
Hietanen, E., and Greenwood, M. R. C., 1976, lipoprotein lipase activity in epididymal fat pads of growing rats, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 35:502 (abstract).
Hirsch, J., and Han, P. W., 1969, Cellularity of rat adipose tissue: Effects of growth, starvation, and obesity, J. Lipid Res. 10:77.
Hirsch, J., and Knittle, J. L., 1970, Cellularity of obese and nonobese human adipose tissue, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 29:1516.
Hurley, L. S., 1976, Trace elements and teratogenesis, Med. Clin. North Amer. 60:771.
Hytten, F. E., and Thomson, A. M., 1970, Maternal physiological adjustments, in: Maternal Nutrition and the Course of Pregnancy, pp. 41–73, National Academy of Sciences, Washington, D.C.
Jameson, S., 1976, Effects of zinc deficiency in human reproduction, Acta Medica Scand., Suppl. 593, p. 1.
Jasper, H. G., and Brasel, J. A., 1973, The effects of growth hormone on DNA polymerase activity in the liver of normal and hypophysectomized rats, Endocrinology 92:194.
Jasper, H. G., and Brasel, J. A., 1974, Rat liver DNA synthesis in the “catch-up” growth of nutritional rehabilitation, J. Nutr. 104:405.
Johnson, P. R., Stern, J. S., Greenwood, M. R. C., Zucker, L. M., and Hirsch, J., 1973, Effect of early nutrition on adipose cellularity and pancreatic insulin release in the Zucker rat, J. Nutr. 103:738.
Kohrs, M. B., Harber, A. E., and Kerr, G. R., 1976, Effects of a low-protein diet during pregnancy of the rhesus monkey. 1. Reproductive efficiency, Amer. J. Clin.Nutr. 29:136.
Kraft, N., and Shortman, K. A., 1970, A suggested control function for the animal tissue ribonuclease-ribonuclease inhibitor system, based on studies of isolated cells and phytohaemagglutinin-transformed lymphocytes, Biochim. Biophys. Acta 217:164.
Kral, J. G., 1976, Surgical reduction of adipose tissue in male Sprague-Dawley rat, Amer. J. Physiol. 231:1090.
Lechtig, A., Habicht, J.-P., Yarbrough, C., Delgado, H., Guzman, G., and Klein, R. E., 1975, Influence of food supplementation during pregnancy on birth weight in rural populations of Guatemala, in: Nutrition, Proceedings of the IXth International Congress of Nutrition, Prognosis for the Undernourished Surviving Child, Mexico, 1972, Vol. 2, (A. Chavez, H. Bourges, and S. Basta eds.), pp. 44–59, Karger, Basel.
Leventhal, H., Biale, Y., and Ben-Adert, N., 1976, Leukocyte alkaline phosphate determinations and urinary estriol excretion in normal and pathologic pregnancies, J. Reprod. Med. 16:44.
Lewis, C. B., and Winick, M., 1977, Regulation of in vivo ribosomal RNA synthesis and ribosome formation in livers of protein-deficient rats, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 36:1155 (abstract).
Lewis, C. G., Rosso, P., and Winick, M., 1976, Demonstration of the existence of two “developmental” species of RNA in liver and brain cytoplasm, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 35:855 (abstract).
Li, J. B., and Goldberg, A. L., 1976, Effects of food deprivation on protein synthesis and degradation in rat skeletal muscles, Amer. J. Physiol. 231:441.
McKenzie, J. M., Fosmire, G. J., and Sandstead, H. H., 1975, Zinc deficiency during the latter third of pregnancy: Effects on fetal rat brain, liver and placenta, J. Nutr. 105:1466.
Meteoff, J., 1972, Biochemical markers of intrauterine malnutrition, in: Current Concepts in Nutrition, Vol. 2, Nutrition and Fetal Development (M. Winick, ed.), pp. 27–44, John Wiley & Sons, New York.
Metzger, B. E., Unger, R. H., and Freinkel, N., 1977, Carbohydrate metabolism in pregnancy. XIV. Relationships between circulating glucagon, insulin, glucose and amino acids in response to a “mixed meal” in late pregnancy, Metabolism 26:151.
Miller, S. A., 1969, Protein metabolism during growth and development, in: Mammalian Protein Metabolism, Vol. 3 (H. N. Munro, ed.) pp. 183–233, Academic Press, New York.
Millward, D. J., Garlick, P. J., Stewart, R.J. C., Nnanyelugo, D. O., and Waterlow, J. C., 1975, Skeletal-muscle growth and protein turnover, Biochem. J. 150:235.
Monckeberg, F., Donoso, G., Oxman, S., Pak, N., and Meneghello, J., 1963, Human growth hormone in infant malnutrition, Pediatrics 31:58.
Munro, H. N., 1970, Free amino acid pools and their role in regulation, in: Mammalian Protein Metabolism, Vol. 4 (H. N. Munro, ed.), pp. 299–386, Academic Press, New York.
Muzzo, S., and Brasel, J. A., 1973, Neonatal hypothyroidism and DNA synthesis in rat cerebellum, presented at the 55th Annual Meeting of the Endocrine Society, June, 1973.
Muzzo, S., Gregory, T., and Gardner, L. I., 1973, Oxygen consumption by brain mitochondria of rats malnourished in utero in the metabolism, J. Nutr. 103:314.
Naismith, D. J., and Fears, R. B., 1971, Adaptations of protein during pregnancy in the rat, Proc. Nutr. Soc. 31:8A.
Naismith, D. J., and Morgan, B. L. G., 1975, The regulation of protein metabolism during pregnancy in the rat, Proc. Nutr. Soc. 34:27A.
Naismith, D. J., and Morgan, B. L. G., 1976, The biphasic nature of protein metabolism during pregnancy in the rat, Br. J. Nutr. 36:563.
Nitzan, M., Freinkel, N., Metzger, B. E., Unger, R. H., Faloona, G. R., and Daniel, R. R., 1975, The interrelations of glucose, insulin and glucagon after overnight fast and in response to oral glucose during late pregnancy, Isr. J. Med. Sci. 11:617.
Nnanyelugo, D. O., 1976, Changes in RNA content during chronic protein deprivation in the hind limb muscles of rats, Nutr. Rep. Int. 14:209.
Ogata, E. S., and Holliday, M. A., 1976, The effects of starvation glucose infusion and normal feeding on muscle protein synthesis and catabolism in the newborn guinea pig, Biol. Neonate 29:247.
Penney, D., Anderson, D., and Dongas, J., 1976, Effects of early severe malnutrition on heart and skeletal muscle lactate dehydrogenase, J. Nutr. 106:1235.
Pimstone, B. L., Beck, D. J., and Hansen, J. D. L., 1973, Human growth hormone and sulphation factor in protein-calorie malnutrition, in: Endocrine Aspects of Malnutrition, Kroc Found. Symp., No. 1 (L. I. Gardner and P. Amacher, eds.), pp. 73–90, Kroc Foundation, Santa Ynez, California.
Powley, T. L., and Morton, S. A., 1976, Hypophysectomy and regulation of body weight in the genetically obese Zucker rat, Amer. J. Physiol. 230:982.
Quirin-Stricker, C., and Mandel, P., 1968, Etude du renouvellement du RNA des polysomes, du RNA de transfert et du RNA “messager” dans le foie de rat soumis a un jeune proteique, Bull. Soc. Chim. Biol. 50:31.
Riopelle, A. J., Hale, P. A., and Watts, E. S., 1976, Protein deprivation in primates. VII. Determinants of size and skeletal maturity at birth in Rhesus monkeys, Hum. Biol. 48:203.
Rosso, P., and Raguso, L., 1972, RNase activity: Rate of RNA degradation and cellular RNA content, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 31:697.
Rosso, P., and Winick, M., 1975, Effects of early undernutrition and subsequent refeeding on alkaline ribonuclease activity of rat cerebrum and liver, J. Nutr. 105:1104.
Rosso, P., Nelson, M., and Winick, M., 1973, Changes in cellular RNA content and alkaline ribonuclease activity in rat liver during development, Growth 37:143.
Rozovski, J., Winick, M., and Rosso, P., 1976, Adaptive changes in polyamine metabolism during malnutrition and refeeding, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 35:341 (abstract).
Salans, L. B., Cushman, S. W., and Weismann, R. E., 1973, Studies of human adipose tissue—adipose cell size and number in nonobese and obese patients, J. Clin. Invest. 52:929.
Shrader, R. E., Hastings-Roberts, M. M., Ferlatte, M. L., and Zeman, F. J., 1977a, Effect of prenatal protein deprivation on fetal and neonatal thyroid morphology in the rat, J. Nutr. 107;213.
Shrader, R. E., Ferlatte, M. I., Hastings-Roberts, M. M., Schoenborne, B. M., Hoernicke, C. A., and, Zeman, F. J., 1977b, Thyroid funcion in prenatally protein-deprived rats, J. Nutr. 107:221.
Stein, T. P., Oram-Smith, J. C., Leskiw, M. J., Wallace, H. W., Long, L. C., and Leonard, J. M., 1976, Effect of nitrogen and calorie restriction on protein synthesis in the rat, Amer. J. Physiol. 230:1321.
Tagliamonte, B., Benedetti, C., and Spadoni, M. A., 1972, Effect of refeeding on liver thymidine-kinase activity of food restricted suckling rats, Nutr. Rep. Int. 5:305.
Winick, M., 1968, Cellular response with increased feeding in pituitary dwarf mice, J. Nutr. 94:121.
Winick, M., and Grant, P., 1968, Cellular growth in the organs of the hypopituitary dwarf mouse, Endocrinology 83:544.
Zamenhof, S., Van Marthens, E., and Grauel, L., 1971, Prenatal cerebral development: Effect of restricted diet, reversal by growth hormone, Science 174:954.
Zucker, L. M., and Antoniades, H. N., 1972, Insulin and obesity in the Zucker genetically obese rat “fatty,” Endocrinology 90:1320.
Zucker, L. M., and Zucker T. F., 1961, Fatty, a new mutation in the rat, J. Hered. 52:275.
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Winick, M. (1978). Nutrition, Growth, and Development. In: Freinkel, N. (eds) The Year in Metabolism 1977. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2499-7_10
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