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Hormonal Control of Mammalian Skin Glands

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Chemical Signals in Vertebrates

Abstract

Apart from the footpad glands, and the eccrine glands of certain primates, both of which develop independently of hair follicles and neither of which are primarily sources of odour, mammalian glands are of two kinds. Each arises in development as an outpushing from the hair follicle. In the holocrine glands, by definition, a lipid secretion is formed by complete disintegration of the cells which are replenished by cell division at the alveolar periphery; in the tubular apocrine glands the secretory process allegedly involves destruction of the cell apices at the luminal border (Schiefferdecker, 1917, 1922). Individual holocrine or sebaceous glands are dispersed throughout the hairy skin in all mammals except whales, and dispersed apocrine glands occur in some mammalian families. Specialized scent glands are aggregations of units of either or both types. Both dispersed or aggregated glands are influenced by hormones. The endocrine control of several species has been studied; previous reviews include those of Ebling (1972) and Strauss and Ebling (1970).

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References

  • Bruchovsky, N. and Wilson, J.D. 1968. Conversion of testosterone to 5a–androstan–1713–01–3–one by rat prostate in vivo and in vitrç. J. Biol. Chem. 243: 2012–2021.

    Google Scholar 

  • Burdick, K.H. and Hill, R. 1970. The topical effect of the anti- androgen chlormadinone acetate and some of its chemical modifications on the hamster costovertebral organ. Br. J. Derm. 82 (Suppl. 6): 19–25.

    Article  CAS  Google Scholar 

  • Clevedon Brown, J. and Williams, J.D. 1972. The rodent preputial gland. Mamm. Rev. 2: 105–147.

    Article  Google Scholar 

  • Doty, R.L. and Kart, R. 1972. A comparative and developmental analysis of the mid-ventral sebaceous glands in 18 taxa of Peromyscus, with an examination of gonadal steroid inf luences in Peromyscus maniculatus Bairdii. J. Mammal. 53: 83–99.

    Article  PubMed  CAS  Google Scholar 

  • Dryden, G.L. and Conaway, C.H. 1967. The origin and control of scent production in Suncus murinus. J. Mammal. 48: 420427.

    Google Scholar 

  • Ebling, F.J. 1957. The action of testosterone on the sebaceous glands and epidermis in castrated and hypophysectomized male rats. J. Endocr. 15: 297–306.

    Article  PubMed  CAS  Google Scholar 

  • Ebling, F.J. 1961. Failure of progesterone to enlarge sebaceous glands in the female rat. Br. J. Derm. 73: 65–68.

    Article  CAS  Google Scholar 

  • Ebling, F.J. 1963. Hormonal control of the sebaceous gland in experimental animals. Pages 200–219. in W. Montagna, R. A. Ellis and A. F. Silver (ed.), Advances in Biology of Skin; Volume 4: Sebaceous Glands. Pergamon Press, Oxford.

    Google Scholar 

  • Ebling, F.J. 1967. The action of an antiandrogenic steroid, 17amethyl-B-nortestosterone, on sebum secretion in rats treated with testosterone. J. Endocr. 38: 181–185.

    Article  PubMed  CAS  Google Scholar 

  • Ebling, F.J. 1970. Steroid hormones and sebaceous secretion. in M. H. Briggs (ed.) Advances in Steroids, Volume 2. Academic Press, London.

    Google Scholar 

  • Ebling, F.J. 1972. The response of the cutaneous glands to steroids. Gen. Comp. Endocr. Suppl. 3: 228–237.

    Article  Google Scholar 

  • Ebling, F.J. 1973. The effects of cyproterone acetate andestradiol upon testosterone stimulated sebaceous activity in the rat. Acta Endocr. 72: 361–365.

    PubMed  CAS  Google Scholar 

  • Ebling, F.J. 1974. Hormonal control and methods of measuring sebaceous gland activity. J. invest. Derm. 62: 161–171.

    Article  PubMed  CAS  Google Scholar 

  • Ebling, F.J., Ebling,E., McCaffery, V. and Skinner, J. 1971. The response of the sebaceous glands of the hypophysectomizedcastrated male rat to 5a-dihydrotestosterone, androstenedione, dehydroepiandrosterone and androsterone. J. Endocr. 51: 18 1190.

    Google Scholar 

  • Ebling, F.J., Ebling, E., McCaffery, V. and Skinner, J. 1973. The responses of the sebaceous glands of the hypophysectomized-castrated male rat to 5a-androstanedione and 5a-andro= stane-3ß:17ß-diol. J. invest. Derm. 60: No. 2, 183–187.

    Article  PubMed  CAS  Google Scholar 

  • Ebling, F.J., Ebling, E., Randall, V. and Skinner, J. 1975a. The sebotrophic action of bovine growth hormone (BGH) in the rat. Br. J. Derm. 92: 325–332.

    Article  CAS  Google Scholar 

  • Ebling, F.J., Ebling, E., Randall, V. and Skinner, J. 1975b. The effects of hypophysectomy and of bovine growth hormone on the responses to testosterone of prostate, preputial, Harderian and lachrymal glands and of brown adipose tissue in the rat. J. Endocr. 66: 401–406.

    Article  PubMed  CAS  Google Scholar 

  • Ebling, F.J., Ebling, E., Randall, V. and Skinner, J. 1975c. The synergistic action of a-MSH and testosterone on the sebaceous, prostate, preputial, Harderian and lachrymal glands and brown adipose tissue in hypophysectomized rats. J. Endocr. 66: 407–412.

    Article  PubMed  CAS  Google Scholar 

  • Ebling, F.J., Ebling, E. and Skinner, J. 1969a. The influence of pituitary hormones on the response of the sebaceous glands of the rat to testosterone. J. Endocr. 45: 245–256.

    Article  PubMed  CAS  Google Scholar 

  • Ebling, F.J., Ebling,E. and Skinner, J. 1969b. The influence of the pituitary on the response of the sebaceous and preputial glands of the rat to progesterone. J. Endocr. 45: 257–263.

    CAS  Google Scholar 

  • Ebling, F.J., Ebling, E. and Skinner, J. 1970a. The effects of thyrotrophic hormone and of thyroxine on the response of the sebaceous glands of the rat to testosterone. J. Endocr. 48: 83–90.

    Article  PubMed  CAS  Google Scholar 

  • Ebling, F.J. and Skinner, J. 1967. The measurement of sebum production in rats treated with testosterone and oestradiol. Br. J. Derm. 79: 386–393.

    Google Scholar 

  • Ebling, F.J. and Skinner, J. 1975. The removal and restitution of hair fat in the rat. Br. J. Derm. 92: 321–324.

    Article  CAS  Google Scholar 

  • Ebling, F.J., Ebling, E., Skinner, J., and White, A. 1970b. The response of the sebaceous glands of hypophysectomizedcastrated male rats to adrenocorticotrophic hormone and to testosterone. J. Endocr. 48: 73–81.

    Article  PubMed  CAS  Google Scholar 

  • Flamigni, C.A., Collins, W.P., Koullapis, E.N. and Sommerville, I.F. 1970. Formation and metabolism of testosterone in rat skin. Endocrinology 87: 764–770.

    Article  PubMed  CAS  Google Scholar 

  • Frost, P., Giegel, J.L., Weinstein, G.D. and Gomez, E.C. 1973. Biodynamic studies of hamster flank organ growth: hormonal influences. J. invest. Derm. 61: 159–167.

    Article  PubMed  CAS  Google Scholar 

  • Glenn, E.M. and Gray, J. 1965. Effect of various hormones on the growth and histology of the gerbil ( Meriones unguiculatus) abdominal sebaceous gland pad. Endocrinology, 76: 1115–1123.

    Article  PubMed  CAS  Google Scholar 

  • Gomez, E.C., Llewellyn, A. and Frost, P. 1974. Metabolism of testosterone-4–14C by hamster skin. J. invest. Derm. 63: 383–387.

    Article  PubMed  CAS  Google Scholar 

  • Hamilton, J.B. and Montagna, W. 1950. The sebaceous glands of the hamster. I. Morpholgical effects of androgens on integumentary structures. Am. J. Anat. 86: 191–234.

    Article  PubMed  CAS  Google Scholar 

  • Haskin, D., Lasher, N. and Rothman, W. 1953. Some effects of ACTH,cortisone, progesterone and testosterone on sebaceous glands in the white rat. J. invest. Derm. 20: 207–211.

    PubMed  CAS  Google Scholar 

  • Huggins, C., Parsons, F.M. and Jensen, E.V. 1955 Promotion of growth of preputial glands by steroids and the pituitary growth hormone. Endocrinology, 57: 25–32.

    Article  PubMed  CAS  Google Scholar 

  • Jarrett, A. 1955. The effects of stilboestrol on the surface sebum and upon acne vulgaris. Br. J. Derm. 67: 165–179.

    Article  Google Scholar 

  • Jarrett, A. 1959. The effects of progesterone and testosterone on surface sebum and acne vulgaris. Br. J. Derm. 71: 102–116.

    Article  CAS  Google Scholar 

  • King, R.J.B. and Mainwaring, W.I.P. 1975. Steroid-cell interactions. Butterworths, London.

    Google Scholar 

  • Krähenbühl, C. and Desaulles, P.A. 1969. Interactions between a-MSH and sex steroids on the preputial glands of female rats. Experientia, 25: 1193–1195.

    Article  PubMed  Google Scholar 

  • Lorincz, A.L. and Lancaster, G. 1957. Anterior pituitary preparation with tropic activity for sebaceous, preputial and Harderian glands. Science 126: 209–222.

    Article  Google Scholar 

  • Martan, J. 1962. Effect of castration and androgen replacement on the supracaudal gland of the male guinea pig. J. Morph. 110: 285–298.

    Article  PubMed  CAS  Google Scholar 

  • Martan, J. and Price, D. 1967. Comparative responsiveness of supracaudal and other sebaceous glands in male and female guinea pigs to hormone. J. Morph. 121: 209–222.

    Article  PubMed  CAS  Google Scholar 

  • Milne, J.A. 1969. The metabolism of androgens by sebaceous glands. Br. J. Derm. 81: 23–28.

    Article  CAS  Google Scholar 

  • Mitchell, O.G. and Butcher, E.O. 1966. Growth of hair in the ventral glands of castrate gerbils following testosterone administration. Anat. Rec. 156: 11–18.

    Article  PubMed  CAS  Google Scholar 

  • Montagna, W. and Kenyon, P. 1949. Growth potentials and mitotic division in the sebaceous glands of the rabbit. Anat. Rec. 103: 365–380.

    Article  PubMed  CAS  Google Scholar 

  • Mykytowycz, R. 1966a. Observations on odoriferous and other glands in the Australian wild rabbit, Oryctolagus cuniculus ( L.) and the hare, Lepus europaeus P. I. The anal gland. CSIRO Wildl. Res. 11: 11–29.

    Article  Google Scholar 

  • Mykytowycz, R. 1966b. Observations on the odoriferous and other glands in the Australian wild rabbit, Oryctolagus cuniculus ( L.), and the hare, Lepus europaeus P. II. The inguinal glands. CSIRO Wildl. Res. 11: 49–64.

    Article  Google Scholar 

  • Mykytowycz, R. 1966c. Observations on odoriferous and other glands in the Australian wild rabbit, Oryctolagus cuniculus ( L.), and the hare, Lepus europaeus P. III. Harder’s, lachrymal and submandibular glands. CSIRO Wildl. Res. 11: 65–90.

    Article  Google Scholar 

  • Pochi, P.E. and Strauss, J.S. 1969. Sebaceous gland response in man to the administration of testosterone, A4- androsteredione, and dehydroisoandrosterone. J. invest. Derm. 52: 32–36.

    PubMed  CAS  Google Scholar 

  • Pochi, P.E. and Strauss, J.S. 1974. Endocrinological control of the development and activity of the human sebaceous gland. J. invest. Derm. 62: 191–201.

    Article  PubMed  CAS  Google Scholar 

  • Sansone-Bazzano, G and Reisner, R. N: 1974. Steroid pathways in sebaceous glands. J. invest. Derm. 62: 211–216.

    Article  Google Scholar 

  • Schiefferdecker, P. 1917. Die Hautdrüsen des Menschen und der Säugetiere, ihre biologische und rassenanatomische Bedeutung, sowie die muscularis sexualis. Biol. Zbl. 37: 534–562.

    Google Scholar 

  • Schiefferdecker, P. 1922. Die Hautdrüsen des Menschen und der Säugetiere, ihre biologische und rassenanatomische Bedeutung, sowie die muscularis sexualis. Zoologica, 27: 1–154.

    Google Scholar 

  • Shuster, S. and Thody, A.J. 1974. The control and measurement of sebum secretion. J. invest. Derm. 62: 172–190.

    Google Scholar 

  • Strauss, J.S. and Ebling, F.J. 1970. Control and function of skin glands in mammals. Mem. Soc. Endocr. 18: 341–371.

    Google Scholar 

  • Strauss, J.S. and Kligman, A.M. 1961. The effect of progesterone and progesterone-like compounds on the human sebaceous gland. J. invest. Derm. 36: 309–318.

    Google Scholar 

  • Strauss, J.S., Kligman, A.M. and Pochi, P.E. 1962. The effect of androgens and estrogens on human sebaceous glands. J. invest. Derm. 39: 139–155.

    Google Scholar 

  • Strauss, J.S. and Pochi, P.E. 1961. The quantitiative gravimetric determination of sebum production. J. invest. Derm. 36: 293298.

    Google Scholar 

  • Strauss, J.S. and Pochi, P.E. 1963. The human sebaceous gland: its regulation by steroidal hormones and its use as an end organ for assaying androgenicity in vivo. Recent Prog. Horm. Res. 19: 385–444.

    Google Scholar 

  • Strauss, J.S. and Pochi, P.E. 1969. Recent advances in androgen metabolism and their relation to the skin. Archs. Derm. 100: 621–636.

    Google Scholar 

  • Thodv, A.J. and Shuster, S. 1972. A study of the relationship between the thyroid gland and sebum secretion in the rat. J. Endocr. 54: 239–244.

    Article  Google Scholar 

  • Thody, A.J. and Shuster, S. 1975. Control of sebaceous gland function in the rat by a-melanocyte stimulating hormone. J. Endocr. 64: 503–510.

    Article  PubMed  CAS  Google Scholar 

  • Wales, N.A.M. and Ebling, F.J. 1971. The control of apocrine glands of the rabbit by steroid hormones. J. Endocr. 51: 763–771.

    Article  PubMed  CAS  Google Scholar 

  • Wilson, J.D. and Walker, J.D. 1969. The conversion of testosterone to 5o(-androstan-l7$-o1–3-one (dihydrotestosterone) by skin slices of man. J. clin. Invest. 48: 371–379.

    Article  PubMed  CAS  Google Scholar 

  • Woodbury, L.P., Lorincz, A. L. and Ortega, P. 1965. Studies on pituitary sebotropic activity. II. Further purification of a pituitary preparation with sebotropic activity. J. Invest. Derm. 45: 364–367.

    PubMed  CAS  Google Scholar 

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© 1977 Plenum Press, New York

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Ebling, F.J. (1977). Hormonal Control of Mammalian Skin Glands. In: Müller-Schwarze, D., Mozell, M.M. (eds) Chemical Signals in Vertebrates. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2364-8_2

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  • DOI: https://doi.org/10.1007/978-1-4684-2364-8_2

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