Abstract
Although a large body of information has been gathered by physicians and scientists during the first half century of the insulin era, human diabetes mellitus is still a poorly understood disease. Most informed individuals agree that although the tendency to develop diabetes may be inherited, environmental factors are also involved in the etiology and the progression of the syndrome’s symptom complex, of which hyperglycemia is the unifying phenomenon. The importance of heredity stems from the well-known familial incidence of diabetes. The importance of environmental factors rests upon evidence suggesting a viral etiology of juvenile-onset diabetes, and upon evidence linking the frequency of maturity-onset diabetes with the degree of nutritional (i.e., caloric) prosperity.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Ingalls, A. M., Dickie, M. M., and Snell, G. D.: J. Hered., 41: 317, 1950.
Renold, A. E.: Adv. Metab. Dis., 3: 49, 1968.
Stauffacher, W., Orci, L., Cameron, D. P., Burr, I. M., and Renold, A. E.: Rec. Progr. Harm. Res., 27: 41, 1971.
Cameron, D. P., Stauffacher, W., and Renold, A. E.: In: Handbook of Physiology. Sec. 7, Endocrinology. Vol. 1, Endocrine Pancreas. Edited by R. O. Greep, E. B. Astwood, D. F. Steiner, N. Freinkel, and S. R. Geiger. Amer. Physiol. Soc., Washington, Chap. 39, 1972, p. 611.
First Brook Lodge Workshop on Spontaneous Diabetes in Laboratory Animals. Diabetologia, 3: 63, 1967.
Second Brook Lodge Workshop on Spontaneous Diabetes in Laboratory Animals. Diabetologia, 6: 12, 1970.
Third Brook Lodge Workshop on Spontaneous Diabetes in Laboratory Animals. Diabetologia, 10: 491, 1974.
Bleisch, V. R., Mayer, J., and Dickie, M. M.: Amer. J. Pathol., 28: 369, 1952.
Wrenshall, G. A., Andrus, S. B., and Mayer, J.: Endocrinology, 56: 335, 1955.
Christophe, J., Dagenais, Y., and Mayer, J.: Nature (London) 184: 61, 1959.
Gepts, W., Christophe, J., and Mayer, J.: Diabetes, 9: 63, 1960.
Hellman, B., Brolin, S. E., Hellerström, C., and Hellman, K.: Acta Endocrinol., 36: 609, 1961.
Solomon, J., and Mayer, J.: Nature (London) 193: 135, 1962.
Björkman, N., Hellerström, C., and Hellman, B.: Z. Zellforsch., 58: 803, 1963.
Stauffacher, W., Crofford, O.B., Jeanrenaud, B. and Renold, A. E.: Ann. N.Y. Acad. Sci., 131: 528, 1965.
Stauffacher, W., Lambert, A. E., Vecchio, D., and Renold, A. E.: Diabetologia, 3: 230, 1967.
Westman, S.: Acta Soc. Med. Upsal., 73: 81, 1968.
Mahler, R. J., Szabo, O., Adler, K., and Levine, R.: Fed. Proc., 29: 380, 1970.
Mahler, R. J., and Szabo, O.: Amer. J. Physiol., 221: 980, 1971.
Nakamura, M.: Proc. Jap. Acad., 38: 348, 1962.
Nakamura, M., and Yamada, K.: Diabetologia, 3: 212, 1967.
Dulin, W. E., and Wyse, B. M.: Diabetologia, 6: 317, 1970.
Appel, M. C., Chang, A. Y., and Dulin, W. E.: Diabetologia, 10: 625, 1974.
Jones, E. E.: In: Structure and Metabolism of the Pancreatic Islets. Edited by S. E. Brolin, B. Hellman, and H. Knutson. Pergamon Press, Oxford, 1964, p. 189.
Like, A. A., Steinke, J., Jones, E. E., and Cahill, Jr., G. F.: Amer. J. Pathol. 46: 621, 1965.
Cahill, Jr., G. F., Jones, E. E., Lauris, V., Steinke, J., and Soeldner, J. S.: Diabetologia, 3: 171, 1967.
Gleason, R. E., Lauris, V., and Soeldner, J. S.: Diabetologia, 3: 175, 1967.
Meier, H., and Yerganian, G. A.: Proc. Soc. Exp. Biol. Med., 100: 810, 1959.
Gerritsen, G. C., and Dulin, W. E.: Diabetologia, 3: 74, 1967.
Carpenter, A. M., Gerritsen, G. C., Dulin, W. E., and Lazarow, A.: Diabetologia, 3: 92, 1967.
Luse, S. A., Caramia, F., Gerritsen, G. C., and Dulin, W. E.: Diabetologia, 3: 97, 1967.
Butler, L.: Diabetologia, 3: 124, 1967.
Boquist, L.: Acta Pathol. Microbiol. Scand., 75: 399, 1969.
Gerritsen, G. C., and Blanks, M. C.: Diabetologia, 6: 177, 1970.
Gerritsen, G. C., and Dulin, W. E.: Acta Diabetol. Lat. (Suppl. I), 9: 597, 1972.
Like, A. A., Gerritsen, G. C., Dulin, W. E., and Gaudreau, P.: Diabetologia, 10: 501, 1974.
Like, A. A., Gerritsen, G. C., Dulin, W. E., and Gaudreau, P.: Diabetologia, 10: 509, 1974.
Schmidt-Nielson, K., Haines, H. B., and Hackel, D. B.: Science, 143: 689, 1964.
Haines, H. B., Hackel, D. B., and Schmidt-Nielsen, K.: Amer. J. Physiol., 208: 297, 1965.
Hackel, D. B., Schmidt-Nielsen, K., Haines, H. B., and Mikat, E.: Lab. Invest., 14: 200, 1965.
Hackel, D. B., Frohman, L., Mikat, E., Lebovitz, H. E., Schmidt-Nielson, K., and Kinney, T. D.: Diabetes, 15: 105, 1966.
Miki, E., Like, A. A., Steinke, J., and Soeldner, J. S.: Diabetologia, 3: 135, 1967.
Like, A. A., and Miki, E.: Diabetologia, 3: 143, 1967.
Malaisse, W. J., Like, A. A., Malaisse-Lagae, F., Gleason, R. E., and Soeldner, J. S.: Diabetes, 17: 752, 1967.
Miki, E., Like, A. A., Soeldner, J. S., Steinke, J., and Cahill, Jr., G. F.: Metabolism, 15: 749, 1966.
Gonet, A. E., Stauffacher, W., Pictet, R., and Renold, A. E.: Diabetologia, 1: 162, 1965.
Stauffacher, W., Orci, I.., Amherdt, M., Burr, I. M., Balant, L., Froesch, E. R., and Renold, A. E.: Diabetologia, 6: 330, 1970.
Cameron, D. P., Stauffacher, W., Orci, L., Amherdt, M., and Renold, A. E.: Diabetes, 21: 1060, 1972.
Malaisse-Lagae, F., Ravazzola, M., Amherdt, M., Gutzeit, A., Malaisse, W. J., and Orci, L.: Diabetologia, 11: 71, 1975.
Hummel, K. P., Dickie, M. M., and Coleman, D. L.: Science, 153: 1127, 1966.
Coleman, D. L., and Hummel, K. P.: Diabetologia, 3: 238, 1967.
Chick, W. L., and Like, A. A.: Diabetologia, 6: 243, 1970.
Coleman, D. L., and Hummel, K. P.: Diabetologia, 10: 607, 1974.
Like, A. A., and Chick, W. L.: Science, 163: 941, 1969.
Like, A. A., and Chick, W. L.: Diabetologia, 6: 207, 1970.
Like, A. A., and Chick, W. L.: Diabetologia, 6: 216, 1970.
Coleman, D. L., and Hummel, K. P.: Amer. J. Physiol., 217: 1298, 1969.
Coleman, D. L.: Diabetologia, 9: 294, 1973.
Chick, W. L., and Like, A. A.: Diabetologia, 6: 252, 1970.
Hummel, K. P., Coleman, D. L., and Lane, P. W.: Biochem. Genet., 7: 1, 1972.
Coleman, D. L., and Hummel, K. P.: Diabetologia, 9: 287, 1973.
Nakhooda, A. F., Like, A. A., Chappel, C. I., and Marliss, E. B.: Clin. Res., 23: 638A, 1975.
Nakhooda, A. F., Like, A. A., Chappel, C. I., and Marliss, E. B.: Diabetes (Suppl. 1) 25: 378, 1976.
Nakhooda, A. F., Like, A. A., Chappel, C. I., Murray, F. T., and Marliss, E. B.: Diabetes, 26: 100, 1977.
Baetens, D., Coleman, D. L., and Orci, L.: Diabetes (Suppl. 1), 25: 344, 1976.
Kahn, C. R., Neville, Jr., D. M., Gorden, P., Freychet, P. and Roth, J.: Biochem. Biophys. Res. Commun., 48: 135, 1972.
DeMeyts, P., Roth, J., Neville, D. M., Jr., Gavin, J. R., III, and Lesniak, M.A.: Biochem. Biophys. Commun., 55: 154, 1973.
Freychet, P., Laudat, M. H., Laudat, P., Rosselin, G., Kahn, C. R., Gorden, P., and Roth, J.: FEBS Lett., 25: 339, 1972.
Staats, J.: Diabetologia, 11: 325, 1975.
Orci, L., Stauffacher, W., Dulin, W. E., Renold, A. E., and Rouiller, C.: Diabetologia, 6: 199, 1970.
Gepts, W.: Diabetes, 14: 619, 1965.
Craighead, J. E., and McLane, M. F.: Science, 162: 913, 1968.
Klöppel, G., Altenähr, E., and Freychet, P.: Virchows Arch. Path. Anat., 356: 15, 1972.
Like, A. A., and Rossini, A. A.: Science, 193: 415, 1976.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Plenum Press, New York
About this chapter
Cite this chapter
Like, A.A. (1977). Spontaneous Diabetes in Animals. In: Volk, B.W., Wellmann, K.F. (eds) The Diabetic Pancreas. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2325-9_17
Download citation
DOI: https://doi.org/10.1007/978-1-4684-2325-9_17
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-2327-3
Online ISBN: 978-1-4684-2325-9
eBook Packages: Springer Book Archive