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Pancreatitis, Pancreatic Lithiasis, and Diabetes Mellitus

  • Chapter
The Diabetic Pancreas

Abstract

In an earlier review of this topic, coauthored by the second author of this chapter in 1962, pancreatitis and pancreatic lithiasis in their relation to diabetes mellitus were dealt with in separate chapters.1 During the past decade and a half, however, it has become evident that stone formation in the pancreas is nearly always a late phase in the course of chronic or chronic recurrent pancreatitis. Also, while in the past occasional authors2 distinguished between intraductal and parenchymal pancreatic lithiasis, and while it may still be difficult to determine by radiologic means whether the stones lie within the ducts or without,3,4 virtually all recent observers emphasize the exclusively intraductal location of pancreatic calculi.5–16 Seemingly diffuse parenchymal calcifications merely reflect the presence of small amorphous calculi in the finer radicles of the pancreatic ducts; and while the epithelium that lines the radicles may perish due to stasis, pressure necrosis, and infection, careful histologic study will often succeed in demonstrating the presence of remnants of the ductular epithelium immediately adjacent to the concrements.8,14 It is true that calcium deposits may also occur during and after the saponification of necrotic foci of pancreatic fat; however, these soaps, once formed, are absorbed and are not converted to inorganic calcium salts.7 In summarizing these observations, Sarles et al.10 concluded that to differentiate between (ductal) lithiasis and (parenchymal) calcifying pancreatopathy no longer appears justified.

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References

  1. Lazarus, S. S., and Volk, B. W.: The Pancreas in Human and Experimental Diabetes. Grune & Stratton, New York, 1962, pp. 177 and 182.

    Google Scholar 

  2. Mahadeven, R.: Brit. Med. J., 1: 626, 1961.

    Google Scholar 

  3. Hasumura, Y., Sawabu, N., Hayakawa, H., Nishimura, K., and Hirose, S.: Saishin Igaku, 27: 994, 1972.

    PubMed  CAS  Google Scholar 

  4. Pelaez Redondo, J.: Rev. Esp. Enferm. Apar. Dig., 34: 289, 1971.

    Google Scholar 

  5. Geevarghese, P. J., Pillai, V. K., Joseph, M. P., and Pitchumoni, C. S.: J. Assoc. Phys. India, 10: 173, 1962.

    Google Scholar 

  6. Kinnear, T. W. G.: E. Afr. Med. J., 40: 288, 1963.

    CAS  Google Scholar 

  7. Minagi, H., and Margolin, F. R.: Amer. J. Gastroenterol., 57: 139, 1972.

    CAS  Google Scholar 

  8. Osuntokun, B. O.: Brit. J. Ophthalmol., 53: 652, 1969.

    CAS  Google Scholar 

  9. Sarles, H., Gastroenterology, 66: 604, 1974.

    PubMed  CAS  Google Scholar 

  10. Sarles, H., Muratore, R., Sarles, J. C., Guien, C., and Camatte, R.: Dtsch. Med. Wochenschr., 87: 125, 1962.

    PubMed  CAS  Google Scholar 

  11. Sarles, H., and Sarles, J. C.: Verh. Dtsch. Ges. Inn. Med., 70: 773, 1964.

    PubMed  CAS  Google Scholar 

  12. Sarles, H., Sarles, J. C., Pèze, R., Camatte, R., and Delmont, J.: Arch. Mal. Appar. Dig., 51: 469, 1962.

    PubMed  CAS  Google Scholar 

  13. Shaper, A. G.: Lancet, 1: 1223, 1960.

    PubMed  CAS  Google Scholar 

  14. Sonnet, J., Brisbois, R., and Bastin, J. P.: Trop. Geogr. Med., 18: 97, 1968.

    Google Scholar 

  15. Stobbe, K. C., ReMine, W. H., and Baggenstoss, A. H.: Surg. Gynecol. Obstet., 131: 1090, 1970.

    PubMed  CAS  Google Scholar 

  16. Tasaka, S., Arai, Y., Shibata, N., Onda, H., Tanaka, M., and Sekiguchi, E.: Iryo, 21: 616, 1967.

    PubMed  CAS  Google Scholar 

  17. Colbert, R. C.: Southwestern Med., 52: 6, 1971.

    CAS  Google Scholar 

  18. Creutzfeldt, W., Fehr, H., and Schmidt, H.: Schweiz. Med. Wochenschr., 100: 1180, 1970.

    PubMed  CAS  Google Scholar 

  19. Classen, J. N., and Hooper, J.: Amer. Surg., 30: 391, 1964.

    CAS  Google Scholar 

  20. Grott, J. W.: Journées Ann. Diab. Hôtel Dieu, 10: 347, 1969.

    CAS  Google Scholar 

  21. Sarles, H., Sarles, J. C., Camatte, R., Muratore, R., Gaini, M., Guien, C., Pastor, J., and Le Roy, F.: Gut, 6: 545, 1965.

    PubMed  CAS  Google Scholar 

  22. Mathiesen, F. R., and Rasmussen, E.: Acta Chir. Scand., 129: 410, 1965.

    PubMed  CAS  Google Scholar 

  23. Doerr, W.: Verh. Dtsch. Ges. Inn. Med., 70: 718, 1964.

    PubMed  CAS  Google Scholar 

  24. Akzhigitov, G. N., and Strygina, T. A.: Klin. Med., Vol. 46, No. 4, p. 70, 1968.

    CAS  Google Scholar 

  25. Bank, S., Marks, I. N., and Vinik, A. I.: Amer. J. Gastroenterol., 64: 13, 1975.

    CAS  Google Scholar 

  26. Barbier, P., Berge, S., and Jacobs, E.: Acta Gastroenterol. Belg., 30: 329, 1967.

    PubMed  CAS  Google Scholar 

  27. Bartelheimer, H.: Verh. Dtsch. Ges. Inn. Med., 70: 759, 1964.

    PubMed  CAS  Google Scholar 

  28. Fomenko, L. I.: Klin. Khir., 1: 11, 1970.

    PubMed  CAS  Google Scholar 

  29. Hayduk, K., Dürr, F., and Schollmeyer, P.: Dtsch. Med. Wochenschr., 93:913, 1968; Germ. Med. Monthly, 13: 432, 1968.

    Google Scholar 

  30. Lozano Castaneda, O.: Rev. Invest. Clin. (Mexico), 20: 221, 1968.

    Google Scholar 

  31. Nielsen, O. S., and Simonsen, E.: Acta Med. Scand., 185: 459, 1969.

    PubMed  CAS  Google Scholar 

  32. Silva Pozo, J., Martinez, P. M., Leon, J. V., Carnero, A. P., and Rodriguez, J. V.: Rev. Esp. Enferra. Apar. Dig., 32: 373, 1970.

    Google Scholar 

  33. Zakaraya, K. A.: Khirurgiia, 41: 94, 1965.

    Google Scholar 

  34. Strohmeyer, G., Gottesburen, H., and Behr, C.: Dtsch. Med. Wochenschr., 99: 1481, 1974.

    PubMed  CAS  Google Scholar 

  35. Pariente, R., Bignon, J., Liot, F., Labram, C., Chrétien, J., and Brouet, G.: Bull. Soc. Méd. Hôp. Paris, 116: 897, 1965.

    PubMed  CAS  Google Scholar 

  36. Blumenthal, H. T., Probstein, J. G., and Berns, A. W.: Arch Surg., 87: 844, 1963.

    PubMed  CAS  Google Scholar 

  37. Gülzow, M., and Bibergeil, H.: Med. Klin., 62: 496, 1967.

    PubMed  Google Scholar 

  38. O’Sullivan, J. N., Nobrega, F. T., Morlock, C. M., Brown, A. L., Jr., and Bartholomew, L. G.: Gastroenterology, 62: 373, 1972.

    PubMed  Google Scholar 

  39. Pérez Jiménez, F., Hita, J., Cosme, A., Muro, J., and Martinez-Fernandez, A.: Rev. Clin. Espan. 132: 171, 1974.

    Google Scholar 

  40. Malone, J. I.: J. Ped., 85: 825, 1974.

    CAS  Google Scholar 

  41. Cywinsky, J. S., Walker, F. A., White, H., and Traisman, H. S.: Acta Paed. Scand., 54: 597, 1965.

    Google Scholar 

  42. Derot, M., Bour, H., Tutin, M., and Guy-Grand, B.: Diabète 18: 93, 1970.

    PubMed  CAS  Google Scholar 

  43. Johansen, K., and Ornsholt, J.: Metabolism 21: 291, 1972.

    PubMed  CAS  Google Scholar 

  44. Miller, M.: In: Diabetes. Edited by R. H. Williams, P. B. Hoeber, New York, 1960, p. 708.

    Google Scholar 

  45. Bagdade, J. D.: Lancet II: 1041, 1969.

    Google Scholar 

  46. Rudyi, R. V., and Chaplinsky, V. V.: Klin. Med., Vol. 43, No. 11, p. 77. 1965.

    CAS  Google Scholar 

  47. Verdonk, C. A., Palumbo, P. J., Gharib, H., and Bartholomew, L. G.: Diabetologia, 11: 395, 1975.

    Google Scholar 

  48. Hughes, P. O.: Brit. J. Surg., 49: 90, 1961.

    PubMed  CAS  Google Scholar 

  49. Andrews, J. T.: Med. J. Austr. II: 582, 1960.

    Google Scholar 

  50. Delore, K., and Croizat, B.: Lyon Méd., 215: 503, 1966.

    PubMed  CAS  Google Scholar 

  51. Hayduk, K., Kaufmann, W., and Diem, R.: Med. Welt, p. 1936, 1968.

    Google Scholar 

  52. Maclean, D., Murison, J., and Griffiths, P. D.: Brit. Med. J., IV: 757, 1973.

    Google Scholar 

  53. Romer, F. K.: Ugeskr. Laeger, 133: 1920, 1971.

    Google Scholar 

  54. Romer, F. K.: Nord. Med., 86: 1321, 1971.

    PubMed  CAS  Google Scholar 

  55. Witzel, L., Böleskei, P., Porzelt, R., and Haasis, R.: Med. Welt, p. 838, 1971.

    Google Scholar 

  56. Davidson, A. I.: Brit. Med. J., I: 356, 1964.

    Google Scholar 

  57. Gordon, A. G.: Brit. J. Clin. Pract., 19: 697, 1965.

    PubMed  CAS  Google Scholar 

  58. Sjöberg, K. H.: Läkartidningen, 63: 2913, 1966.

    PubMed  Google Scholar 

  59. Belfiore, F., and Napoli, E.: Clin. Chem., 19: 387, 1973.

    PubMed  CAS  Google Scholar 

  60. Haenel, U., and Heuser, R.: Munch. Med. Wochenschr., 109: 1857, 1967.

    PubMed  CAS  Google Scholar 

  61. Woldman, E. E., Fishman, D., and Segal, A. J.: JAMA, 169: 1281, 1959.

    CAS  Google Scholar 

  62. Cawley, T.: London Med. J., 9: 286, 1788.

    Google Scholar 

  63. Chudzikiewicz, T.: Polski Tydg. Lek., 19: 1335, 1964.

    CAS  Google Scholar 

  64. Clarke, S. W.: Proc. Roy. Soc. Med., 59: 856, 1966.

    PubMed  CAS  Google Scholar 

  65. Derouiche, F., El Aifa, K. N., Kallal, Z., and Doghri, T.: Tunisié Méd., 52: 101, 1974.

    PubMed  CAS  Google Scholar 

  66. Espejoy Gomez de Avellaneda, M.: Diabète, 18: 153, 1970.

    Google Scholar 

  67. Hirabayashi, H., and Nomura, M.: Naika, 20: 982, 1967.

    PubMed  CAS  Google Scholar 

  68. Joseph, P. P.: J. Indian Med. Assoc., 44: 35, 1965.

    PubMed  CAS  Google Scholar 

  69. Justin-Besançon, L., Lamotte, M., Lamotte-Barrilon, S., Grivaux, M., and Colomb, G.: Sem. Hop. Paris, 36: 753, 1960.

    PubMed  Google Scholar 

  70. Legré, M., Vignoli, R., and Saint-Pierre, A.: Arch. Mal. Appar. Dig., 51: 1447, 1962.

    PubMed  Google Scholar 

  71. Lewis, T. D.: Austral. New Zeal. J. Med., 4: 518, 1974.

    CAS  Google Scholar 

  72. Meoni, S.: Atti Accad. Fisiocr. Siena (Medicofis.), 14: 501, 1965.

    Google Scholar 

  73. Mowar, S. N.: J. Indian Med. Assoc., 45: 386, 1965.

    PubMed  CAS  Google Scholar 

  74. Naomé, J.: Rév. Med. Liège, 18: 596, 1963.

    PubMed  Google Scholar 

  75. Payet, M., Sankalé, M., Diop, B., Frament, V., Cave, L., Gombert, J., and Rahmi, R.: Bull. Soc. Méd. Afr. Noire Lang. Franç., 11: 456, 1966.

    CAS  Google Scholar 

  76. Picq, J., and Consigny, P.: Diabète, 14: 301, 1966.

    PubMed  CAS  Google Scholar 

  77. Shultsev, G. P.: Klin. Med., Vol. 39, No. 6, p. 43, 1961.

    Google Scholar 

  78. Staniszewski, J., Tuszewski, F., and Szewczyk, Z.: Wiad. Lek., 23: 2115, 1970.

    PubMed  CAS  Google Scholar 

  79. Takaoka, Y.: Nippon Rinsho, 25: 2733, 1967.

    PubMed  CAS  Google Scholar 

  80. Wenderlich, Z., and Nowak, W.: Wiad. Lek., 25: 2149, 1972.

    PubMed  CAS  Google Scholar 

  81. Anonymous: Journées Ann. Diab. Hôtel Dieu, 9: 417, 1968.

    Google Scholar 

  82. Anonymous: Lancet, II: 1070, 1968.

    Google Scholar 

  83. Darnaud, C.: Révue Int. Hépat., 5: 285, 1955.

    CAS  Google Scholar 

  84. Dettwyler, W.: Sem. Hôp. Paris, 40: 1676, 1964.

    PubMed  CAS  Google Scholar 

  85. Horiuchi, N., Kitamura, T., Nakagawa, F., Sasaki, A., and Inui, H.: Nippon Rinsho, 29: 2146, 1971.

    PubMed  CAS  Google Scholar 

  86. Howard, J. M.: In: Surgical Diseases of the Pancreas. Edited by J. M. Howard and G. L. Jordan, Jr., Pitman Med., London, 1960, p. 203.

    Google Scholar 

  87. Koch, E.: In: Handbuch des Diabetes Mellitus. Edited by E. F. Pfeiffer. Munich, 1971, p. 861.

    Google Scholar 

  88. Lescut, J., and Fourlinnie, J. C.: Lille Méd., 12: 719, 1967.

    PubMed  CAS  Google Scholar 

  89. Martin, E., and Dettwyler, W.: Journées Ann. Diab. Hôt. Dieu, 4: 55, 1963.

    Google Scholar 

  90. Olurin, E. O., and Olurin, O.: Brit. Med. J., IV: 534, 1969.

    Google Scholar 

  91. Tutin, M.: Gaz. Méd. France, 73: 17, 1966.

    PubMed  CAS  Google Scholar 

  92. Fitzgerald, O., Fitzgerald, P., Fennelly, J., McMullin, J. P., and Boland, J. S.: Gut, 4: 193, 1963.

    PubMed  CAS  Google Scholar 

  93. Marks, I. N., and Bank, S.: S. Afr. Med. J., 37: 1039, 1963.

    PubMed  CAS  Google Scholar 

  94. Funakoshi, A., et al.: Nippon Rinsho, 32: 3620, 1974.

    PubMed  CAS  Google Scholar 

  95. Osuntokun, B. O.: J. Neurol. Sci., 11: 17, 1970.

    PubMed  CAS  Google Scholar 

  96. Bourgoignie, J., Sonnet, J., and Dechef, G.: Ann. Soc. Belg. Méd. Trop., 42: 261, 1962.

    CAS  Google Scholar 

  97. Shaper, A. G.: Brit. Med. J., I: 1607, 1964.

    Google Scholar 

  98. Zuidema, P. J.: Trop. Geogr. Med., 11: 70, 1959.

    PubMed  CAS  Google Scholar 

  99. Wicks, A. C. B.: Central Afr. J. Med., 19: 189, 1973.

    CAS  Google Scholar 

  100. Wicks, A. C. B., and Clain, D. J.: Amer. J. Dig. Dis., 20: 1, 1975.

    PubMed  CAS  Google Scholar 

  101. Craighead, J. E.: Progr. Med. Viral., 19: 161, 1975.

    CAS  Google Scholar 

  102. Sato, T., and Saitoh, Y.: Amer. J. Surg., 127: 511, 1974.

    PubMed  CAS  Google Scholar 

  103. Fitzgerald, O., Fitzgerald, P. and McMullin, J. P.: Rev. Surg., 21: 77, 1964.

    PubMed  CAS  Google Scholar 

  104. Gambill, E. E., Baggenstoss, A. H., and Priestley, J. T.: Gastroenterology, 39: 404, 1960.

    PubMed  CAS  Google Scholar 

  105. Makiyama, H., and Kita, K.: Naika, 22: 779, 1968.

    Google Scholar 

  106. Moorthy, S. S., Sankaran, K., Varghese, C. V. J., Jeyamitra, D., and Sen, S. B.: J. Indian Meu Assoc., 59: 57, 1972.

    CAS  Google Scholar 

  107. Goodall, J. W., and Pilbeam, S. T.: Trans. Roy. Soc. Trop. Med. Hyg., 58: 575, 1964.

    PubMed  CAS  Google Scholar 

  108. Lescut, J.: Lille Méd., 13: 46, 1968.

    PubMed  CAS  Google Scholar 

  109. Potet, F., Barge, J., and Duclert, N.: Arch. Anat. Pathol., 18: 219, 1970.

    CAS  Google Scholar 

  110. Vachon, A., and Abry, M.: Actual. Hépatogast. Hôtel Dieu, 1964, p. 96.

    Google Scholar 

  111. Ammann, R.: Dtsch. Med. Wochenschr., 95: 1, 1970.

    PubMed  CAS  Google Scholar 

  112. Müller-Wieland, K.: Dtsch. Med. Wochenschr., 93: 391, 1968.

    PubMed  Google Scholar 

  113. Vaissman, I., Kamel, D., Manhaes H., Veloso, E., and Basser, H. W.: Arq. Bras. Endocrin. Metab., 18: 35, 1969.

    Google Scholar 

  114. Oda, M.: Nippon Rinsho, 25: 299, 1967.

    PubMed  CAS  Google Scholar 

  115. Canivet, J., and Battesti, J. P.: Diabète, 5: 191, 1961.

    Google Scholar 

  116. Sprague, R. G.: Proc. Staff Meet. Mayo Clin., 22: 553, 1947.

    PubMed  CAS  Google Scholar 

  117. Baikalov, L. K., Lemeshko, V. I., and Sokolovsky, A. N.: Ter. Ark., Vol. 36, No. 9, p. 70, 1964.

    CAS  Google Scholar 

  118. Deuil, R.., and Chavanat, B.: Gaz. Méd. France, 67: 2241, 1960.

    PubMed  CAS  Google Scholar 

  119. Friedlander, E. O.: Ann. Int. Med., 52: 838, 1960.

    PubMed  CAS  Google Scholar 

  120. Gepts, W.: In: 14. Symposium der Deutschen Gesellschaft für Endokrinologie. Springer Verlag, Heidelberg, 1960, p. 101.

    Google Scholar 

  121. Halmos, T., Korânyi, L., Salamon, F., Szücs, L., and Tarjânyi, M.: Endokrinologie, 63: 43, 1974.

    PubMed  CAS  Google Scholar 

  122. Joffe, B. I., Krut, L., Bank, S., Marks, I. N., and Heller, P.: Metabolism, 19: 87, 1970.

    PubMed  CAS  Google Scholar 

  123. Vachon, A., Cuffia, S., and Shaaban, M.: Révue Int. Hépat. 11: 311, 1961.

    CAS  Google Scholar 

  124. Joffe, B. I., Bank, S., and Marks, I. N.: Lancet, II: 1038, 1968.

    Google Scholar 

  125. Malins, J., and Walsh, C. H.: Brit. Med. J., IV: 757, 1973.

    Google Scholar 

  126. Rogers, J. B., Howard, J. M., and Pairent, F. W.: Amer. J. Surg., 119: 171, 1970.

    PubMed  CAS  Google Scholar 

  127. Peters, N., Dick, A. P., Hales, C. N., Orrell, D. H., and Sarner, M.: Gut, 7: 277, 1966.

    PubMed  CAS  Google Scholar 

  128. Joffe, B. I., Bank, S., Jackson, W. P. U., Keller, P., O’Reilly, I. G., and Vinik, A. I.: Lancet, II: 890, 1968.

    Google Scholar 

  129. Vinik, A. I., Joffe, B. I., Joubert, S. M., and Jackson, W. P. U.: J. Clin. Endocrinol. Metab., 31: 86, 1970.

    PubMed  CAS  Google Scholar 

  130. Bour, H., Derot, M., Tutin, M., Kopf, A., and Cordelier, J. L.: Sem. Hôp. Paris, 47: 2403, 1971.

    PubMed  CAS  Google Scholar 

  131. Creutzfeldt, W., and Perings, E.: Acta Diabet. Lat., Suppl., 1: 432, 1972.

    Google Scholar 

  132. Sevel, D., Bristow, J. H., Bank, S., Marks, I., and Jackson, P.: Arch. Ophthalmol., 86: 245, 1971.

    PubMed  CAS  Google Scholar 

  133. Duncan, L. J. P., MacFarlane, A., and Robson, J. S.: Lancet, I: 822, 1958.

    Google Scholar 

  134. Shapiro, F. I.., and Smith, H. T.: Arch. Int. Med., 117: 795, 1966.

    CAS  Google Scholar 

  135. Wellmann, K. F., and Volk, B. W.: Diabetes, 25: 713, 1976.

    PubMed  CAS  Google Scholar 

  136. Ennis, G., Miller, M., Unger, F. M., and Unger, L.: Diabetes 18: 333, 1969.

    Google Scholar 

  137. Deckert, T.: Acta Med. Scand., 168: 439, 1960.

    PubMed  CAS  Google Scholar 

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  1. Klaus F. Wellmann

    Present address: Beekman Downtown Hospital, New York, New York, USA

  2. Bruno W. Volk

    Present address: University of California, Irvine, California, USA

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  1. Isaac Albert Research Institute of the Kingsbrook Jewish Medical Center, and Downstate Medical Center, State University of New York, Brooklyn, New York, USA

    Klaus F. Wellmann & Bruno W. Volk

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    Bruno W. Volk  & Klaus F. Wellmann  & 

  2. University of California, Irvine, California, USA

    Bruno W. Volk

  3. Beekman Downtown Hospital, New York, USA

    Klaus F. Wellmann

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Wellmann, K.F., Volk, B.W. (1977). Pancreatitis, Pancreatic Lithiasis, and Diabetes Mellitus. In: Volk, B.W., Wellmann, K.F. (eds) The Diabetic Pancreas. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2325-9_12

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