Abstract
The hypothesis that idiopathic diabetes is a result of insufficient secretion of insulin seemed to be confirmed by many earlier experimental studies carried out around the turn of the century. This viewpoint was based on the studies of Von Mering and Minkowski1 who, in 1889, were the first to observe that removal of the pancreas causes diabetes in the dog. The discovery of insulin by Banting and Best2 in 1922 seemed to support this hypothesis, since the administration of pancreatic extracts could correct the metabolic abnormalities in diabetes. This was in keeping with the frequently observed atrophy of the pancreatic islets,3–7 the decrease of extractable insulin8–10 in pancreases of juvenile diabetics, and the occurrence of interacinar fibrosis, insular fibrosis, and hyalinization in the pancreases of maturity-onset diabetics.11 Moreover, quantitative studies by various authors indicated a relative increase of A cells in many diabetic pancreases associated with a concomitant decrease of the B cells.7,12–14
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Von Mering, J., and Minkowski, O.: Arch. Exp. Pathol. Pharrnakol., 26: 371, 1889–90.
Banting, F. G., and Best, C. H.: J. Lab. Clin. Med., 7: 464, 1922.
Kraus, E. J.: Virchow’s Arch., 247: 1, 1923–24.
Nakamura, N.: Arch. Pathol. Anat., 253: 286, 1924.
Moore, R. A.: Amer. J. Dis. Child., 52: 627, 1936.
Schwartzman, J., Crusius, M. E., and Beirne, D. P.: Amer. J. Dis. Child., 74: 587, 1947.
Maclean, N., and Ogilvie, R. F.: Diabetes, 8: 83, 1959.
Wrenshall, G. A., Bogoch, A., and Ritchie, R. C.: Diabetes, 1: 87, 1952.
Wrenshall, G. A., Hartroft, W. S., and Best, C. H.: Diabetes, 3: 444, 1954.
Hartroft, W. S., and Wrenshall, G. A.: Diabetes, 4: 1, 1955.
Lazarus, S. S., and Volk, B. W.: The Pancreas in Human and Experimental Diabetes. Grune & Stratton, New York, 1962, p. 196.
Gomori, G.: Amer. J. Pathol., 17: 395, 1941.
Gepts, W.: Ann. Soc. Roy. Sci. Mid. Nat. Brux., 10: 5, 1957.
Gepts, W.: Endokrinologie, 36: 185, 1958.
Bell, E. T.: Diabetes, 2: 125, 1953.
Bornstein, J.: J. Endocrinol., 7: 59, 1953.
Bornstein, J.: Diabetes, 2: 23, 1953.
Bertram, F., Bendfeldt, E., and Otto, H.: Dtsch. Med Wochenschr., 80: 1455, 1955.
Beaser, S. B.: Metabolism, 5: 933, 1956.
Gepts, W., and Gregoire, F.: In: Recent Progress in Quantitative Microhistochemistry. Edited by U. C. Dubach. Hans Huber, Bern/Stuttgart, 1972, p. 300.
Malaisse, W.: Etude de la Secretion Insulinique In Vivo. Editions Arscia, Brussels, 1968.
Malaisse, W., Malaisse-Lagae, V., Geritzen, G. G., Dulin, W. E., and Wright, P. M.: Diabetologia, 3: 109, 1967.
Moschcowitz, E.: Ann. Int. Med., 34: 1137, 1951.
Lazarus, S. S., and Volk, B. W.: The Pancreas in Human and Experimental Diabetes. Grune & Stratton, New York 1962, p. 197.
Houssay, B. A.: Amer. J. Med. Sci., 193: 581, 1937.
Long, C. N. H., and Lukens, F. D. W.: J. Exp. Med., 63: 465, 1936.
Young, F. G.: Lancet, 2: 372, 1937.
Rimoin, D.: Diabetes, 16: 346, 1967.
Valiance-Owen, J.: Diabetes, 13: 241, 1964.
Antoniades, H. N., Gundersen, K., Beigelman, P. M., Pyle, H. M., and Bougas, J. A.: Diabetes, 11: 261, 1962.
Randle, P. J., Garland, P. B., Hales, C. N., and Newsholme, E. A.: Lancet, 1: 785, 1963.
Randle, P. J., Garland, P. B., Hales, C. N., Newsholme, E. A., Denton, R. M., and Pogson, C. I.: Rec. Progr. Horm. Res., 22: 1, 1966.
Pay, J., Jezkova, Z., and Skrha, F.: Lancet, 2: 221, 1963.
Chetty, M. P., and Watson, K. C.: Lancet, 1: 67, 1965.
Deckert, T.: Acta Med. Scand. Suppl., 476: 30, 1967.
Mancini, A. M., Zampa, G. A., Vecchi, A., and Costanzi, G.: Lancet, 1: 1189, 1965.
Yalow, R., and Berson, S.: J. Clin. Invest., 39: 1157, 1960.
Steinke, J., Camerini, R., Marble, A., and Renold, A.: Metabolism, 10: 707, 1961.
Renold, A. E., and Steinke, J.: In: Fortschritte der Diabetesforschung. Edited by K. Oberdisse and J. Jahnkes. Georg Thieme Verlag, Stuttgart, 1963, p. 1.
Seltzer, H. S., and Harris, V. L.: Diabetes, 13: 6, 1964.
Seltzer, H. S., Allen, E. W., Herron, Jr., A. L., and Brennan, M. T.: J. Clin. Invest., 46: 323, 1967.
Cerasi, E., and Luft, R.: Acta Endocrinol., 55: 278, 1967.
Cerasi, E., and Luft, R.: Acta Endocrinol., 55: 305, 1967.
Cerasi, E., and Luft, R.: Acta Endocrinol., 55: 330, 1967.
Cerasi, E., and Luft, R.: Diabetes, 16: 615, 1967.
Murlin, J. R., Clough, H. G., Gibbs, C. B., and Stokes, A. M.: J. Biol. Chem., 56: 253, 1933.
Kimball, C. P., and Murlin, J. R.: J. Biol. Chem., 58: 337, 1933.
Collens, W. S., and Murlin, J. R.: Proc. Soc. Exp. Biol. Med., 26: 485, 1929.
Van Campenhout, E., and Cornelis, G.: C. R. Soc. Biol., 145: 933, 1951.
Ferner, W.: Z. Mikrosk. Anat. Forschung, 44: 451, 1938.
Ferner, W.: Virchow’s Arch., 309: 87, 1942.
Ferner, W.: Dtsch. Ztsch. f. Verdauungskr., 6: 21, 1942.
Ferner, W.: Das Inselsystem des Pankreas. George Thieme Verlag, Stuttgart 1952, p. 74.
Aguilar-Parada, E., Eisentraut, A. M., and Unger, R. H.: Amer. J. Med. Sci., 257: 415, 1969.
Unger, R. H., Aguilar-Parada, E., Muller, W. A., and Eisentraut, A. M.: J. Clin. Invest., 49: 837, 1970.
Muller, W. A., Faloona, G. R., Aguilar-Parada, E., and Unger, R. H.: N. Engl. J. Med., 283: 109, 1970.
Unger, R. H., Madison, L. L., and Muller, W. A.: Diabetes, 21: 301, 1972.
Frankel, B. J., Gerich, J. E., Ryoko, H., Fanska, R. E., Gerritsen, G. C., and Grodsky, G. M.: J. Clin. Invest., 53: 1637, 1974
Assan, R., Hautecouverture, G., Guillemant, S., Douchy, E., Protin, P., and Derot, M.: Pathol. Biol., 17: 1095, 1969.
Buchanan, K. D., and McCarrol, A. M.: Lancet, 2: 1395, 1972.
Felig, P., Pozefsky, T., Marliss, E., and Cahill, G. F., Jr.: Science, 167: 1003, 1970.
Gerich, J. E., Langlois, M., Noacco, C., Karam, J. H., and Forsham, P. H.: Science, 182: 171, 1973.
Kalkhoff, R. K., Gossain, V. V., and Mature, M. L.: N. Engl. J. Med., 289: 465, 1973.
Muller, W. A., Faloona, G. R., and Unger, R. H.: J. Clin. Invest., 50: 1992, 1971.
Meier, J. M., McGarry, J. D., Faloona, G. R., Unger, R. H., and Foster, D.: J. Lipid Res., 13: 228, 1972.
Katsilambros, N. Y., Abdel, R., Minz, M., Fussganger, K. E., Schroder, K. E., Straug, K., and Pfeiffer, E. F.: Harm. Metab. Res., 2: 268, 1970.
Amherdt, M., Harris, V., Renold, A. E., Orci, L., and Unger, R. H.: J. Clin. Invest., 54: 188, 1974.
Samols, E., Tyler, J. M., and Kajinuma, H.: In: Proceedings of the Seventh Congress of the International Diabetes Federation. Edited by R. R. Rodriguez and J. Valiance-Owen. Excerpta Medica, Amsterdam, 1971, p. 636.
Lindsey, C. A., Santeusanio, F., Braaten, J., Faloona, G. R., and Unger, R. H.: JAMA, 227: 757, 1975.
Willmore, D. W., Lindsey, C. A., Faloona, G. R., Moylan, J., Pruitt, B., and Unger, R. H.: Lancet, 1: 73, 1974.
Willerson, J. T., Hutcheson, D., Leshin, S. J., Faloona, G. R., and Unger, R. H.: Amer. J. Med., 57: 747, 1974.
Pek, S., Vranic, M., and Kawamori, R.: Program of the Fifth Annual Meeting of the Endocrine Society, 1974, A176.
Matsuyama, T., and Foa, P. M.: Diabetes, 23: 344, 1974.
Mashiter, K., Harding, P. E., Chou, M., Mashiter, G. D., Stout, J., Diamond, D., and Field, J. B.: Endocrinology, 96: 678, 1975.
Dobbs, R. H., Sakurai, H., Sasaki, H., Faloona, G. R., Valverde, I., Baetens, D., Orci, L., and Unger, R. H.: Science, 187: 544, 1975.
Orci, L., Pictet, R., Forssmann, W. G., Renold, A. E., and Rouiller, C.: Diabetologia, 4: 56, 1968.
Polak, J. M., Bloom, S., Coulling, I., and Pearse, A. G.: Gut, 12: 311, 1971.
Sasaki, A., Faloona, G. R., and Unger, R. H.: Gastroenterology, 67: 746, 1974.
Unger, R. H., and Orci, L.: Lancet, 1: 14, 1975.
Sasaki, H., Rubalcava, B., Baetens, D., Blazquez, E., Srikant, C. B., Orci, L., and Unger, R. H.: J. Clin. Invest., 56: 135, 1975.
Brazeau, P., Vale, W., Burgus, R., Ling, N., Butcher, M., Rivier, J., and Guillemin, R.: Science, 179: 1973.
Mortimer, C. H., Turnbridge, W. M. G., Carr, D., Yeomans, L., Lind, T., Coy, D. H., Bloom, S. R., Kastin, A., Mallinson, C. N., Besser, G. M., Schally, A. V., and Hall, R.: Lancet, 1: 697, 1974.
Koerker, D. J., Ruch, W., Chideckel, E., Palmer, J., Goodner, C. J., Ensinck, J., and Gale, C. C.: Science, 184: 482, 1974.
Johnson, D. G., Ensinck, J., Koerker, D. J., Palmer, J., and Goodner, C. J.: Diabetes (Suppl. 1), 23: 374, 1974.
Iversen, J.: Scand. J. Clin. Lab. Invest., 33: 125, 1974.
Efendic, C., Luft, R., and Grill, V.: FEBS Lett., 42: 169, 1974.
Alberti, K. G., Christensen, N. J., Christensen, S. E., Hansen, A. P., Iversen, J., Lundbaek, K., Seyer-Hansen, K., and Orskov, H.: Lancet 2: 1299, 1973.
Goodner, C. J., Ensinck, J. W., Chideckel, E., Palmer, J., Koerker, D. J., Ruch, W., and Gale, C. C.: J. Clin. Invest., 53: 28a, 1974.
Sakurai, H., Dobbs, R. E., and Unger, R. H.: J. Clin. Invest., 54: 1395, 1974.
Alford, F. P., Bloom, S. R., and Nabarro, J. D. N.: Lancet, 2: 974, 1974.
Glinsman, W. H., and Mortimore, G. E.: Amer. J. Physiol., 215: 553, 1968.
Mackrell, D. J., and Sokal, J. E.: Diabetes, 18: 724, 1969.
Vranick, M.: In: Insulin Action. Edited by I. B. Fritz. Academic Press, New York, 1972, p. 529.
Liljenquist, J. E., Bomboy, J. D., Lewis, S. B., Sinclair-Smith, B. C., Felts, P. W., Lacy, W. W., Crofford, O. B., and Liddle, W.: J. Clin. Invest., 53: 190, 1974.
Pelletier, G., Leclerc, G., Arimura, A., and Schally, A. V.: J. Histochem. Cytochem., 23: 699, 1975.
Orci, L., Baetens, D., Dubois, M. P., and Rufener, C.: Horm. Metab. Res., 7: 400, 1975.
Orci, L., and Unger, R. H.: Lancet, 2: 1243, 1975.
Albisser, A. M., Leibel, B. S., Ewart, T. G., Davidovac, Z., Botz, C. K., Zingg, W., Schipper, H., and Gander, R.: Diabetes, 23: 397, 1074.
Barnes, A. J., Bloom, A., Crowley, M. F., Tuttlebee, J. W., Bloom, W. R., Alberti, K. G. M. M., Smythe, P., and Turnell, D.: Lancet, 2: 734, 1975.
Tasaka, Y., Sekine, M., Wakatsuki, M., Ohgawara, H., and Shizume, K.: Horm. Metab. Res., 7: 205, 1975.
Sherwin, R. S., Fisher, M., Hendler, R., and Felig, P.: N. Engl. J. Med., 294: 455, 1976.
Felig, P., Wahren, J., Sherwin, R., and Hendler, R.: Diabetes, Suppl.l, 25: 323, 1976.
Levine, R.: Editorial. N. Engl. J. Med., 294: 494, 1976.
Barnes, A. J., and Bloom, S. R.: Lancet, 1: 219, 1976.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Plenum Press, New York
About this chapter
Cite this chapter
Volk, B.W., Wellmann, K.F. (1977). Pathogenetic Considerations of Idiopathic Diabetes. In: Volk, B.W., Wellmann, K.F. (eds) The Diabetic Pancreas. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2325-9_10
Download citation
DOI: https://doi.org/10.1007/978-1-4684-2325-9_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-2327-3
Online ISBN: 978-1-4684-2325-9
eBook Packages: Springer Book Archive