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Maturation of Cellular and Humoral Immunity

  • Chapter
Perinatal Physiology

Abstract

In mammals, immunologic responses can be divided into those mediated by humoral antibodies (antibody-mediated immunity) and by cells (cell-mediated immunity). Both depend on the activity of small lymphocytes that are themselves ultimately derived from bone marrow precursors.(226) The stem cells, which originate in the early embryonic stage in the yolk sac and in later stages of development in the liver, and in adults in the bone marrow, differentiate to form two distinct lymphocyte populations, one thymus-derived (T lymphocytes), the other bone-marrow-derived (B lymphocytes)(77,167) The life span of lymphocytes is not uniform. One can distinguish two populations of lymphocytes: a short-lived population of small, medium, and large lymphocytes with a life span of 1–10 days, and a long-lived population of small lymphocytes with a life span of some 100 days(275); some of these small lymphocytes have a life span of 10 years and more.(192)

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References

  1. Abbas, T. M. and Tovey, J. E., 1960, Proteins of the liquor amnii, Br. Med. J. 1:476.

    Article  PubMed  CAS  Google Scholar 

  2. Aherne, W., and Dunnill, M. S., 1966, Morphometry of the human placenta, Br. Med. Bull. 22:5.

    PubMed  CAS  Google Scholar 

  3. Alford, C. A., Reynolds, D. W., and Stagno, S., 1974, Current concepts of chronic perinatal infections, in: Modern Perinatal Medicine (Gluck, ed.), p. 285, Year Book Medical Publishers, Chicago.

    Google Scholar 

  4. Allansmith, M., McClellan, B. H., Butterworth, M., and Maloney, J. R., 1968, The development of immunoglobulin levels in man, J. Pediatr. 72:276.

    Article  PubMed  CAS  Google Scholar 

  5. Ahrons, S., 1971, HL-A-antibodies. Influence on the human foetus, Tissue Antigens 1:129.

    Article  PubMed  CAS  Google Scholar 

  6. Ahrons, S., and Glavind-Kristensen, 1971, Cytotoxic HL-A antibodies. Immunoglobulin classification, Tissue Antigens 1:121.

    Article  PubMed  CAS  Google Scholar 

  7. Allansmith, M., Maloney, J., and Wymer, B., 1966, Change in immunoglobulin levels in the same babies from birth to age 6 months, Fed. Proc. 25:489.

    Google Scholar 

  8. Amoroso, E. C., 1961, Histology of the placenta, Br. Med. Bull. 17:81.

    PubMed  CAS  Google Scholar 

  9. Andreoli, M., and Robbins, J., 1962, Serum proteins and thyroxine-protein interaction in early human fetuses, J. Clin. Invest. 41:1070.

    Article  PubMed  CAS  Google Scholar 

  10. Andres, G. A., Mattiuz, P. L., and Ceppelini, R., 1970, Ontogenesi degli antigeni della istoincompatibilità, 54e Congr. Naz. Soc. Ital. Ost. Ginecol., Milano.

    Google Scholar 

  11. Artenstein, M. S., Bellanti, J. A., and Buescher, E. L., 1964, Identification of the antiviral substances in nasal secretions, Proc. Soc. Exp. Biol. Med. 117:558.

    PubMed  CAS  Google Scholar 

  12. Atkins, H. J. B., 1958, A study in the transmission of maternal antibodies, Br. Med. J. 1:187.

    Article  PubMed  CAS  Google Scholar 

  13. August, C. S., Berkel, A. J., Driscoll, S., and Merler, E., 1971, Onset of lymphocyte function in the developing human fetus, Pediatr. Res 5:539.

    Article  Google Scholar 

  14. Bach, J. F., 1973, Evaluation of T-cells and thymic serum factors in man using the rosette technique, Transplant. Rev. 16:196.

    PubMed  CAS  Google Scholar 

  15. Bangham, D. R., 1960, The transmission of homologous serum proteins to the foetus and to the amniotic fluid in the rhesus monkey, J. Physiol. 153:265.

    PubMed  CAS  Google Scholar 

  16. Bangham, D. R., Hobbs, K. R., and Tee, D. E. H., 1961, The origin and nature of proteins of the liquor amnii in the rhesus monkey; a new protein with some unusual properties, J. Physiol. 158:207.

    PubMed  CAS  Google Scholar 

  17. Barandun, S., Stampfli, K., Spengler, G. H., and Riva, G., 1959, Die Klinik des Antikörpermangelsyndroms (AMS), Helv. Med. Acta 26:163.

    PubMed  CAS  Google Scholar 

  18. Barbanti, A., 1956, II quadro proteico del liquido amniotico valuto elettroforeticamente e suoi rapporti col siero materno e quello fetale, Minerva Ginecol. 8:780.

    Google Scholar 

  19. Bardawil, W. A., Toy, B. L., and Hertig, A. T., 1958, Localization of homologous plasma proteins in the human placenta by fluorescent antibody, Amer. J. Obstet. Gynecol. 75:708.

    CAS  Google Scholar 

  20. Barnes, J. M., 1959, Antitoxin transfer from mother to fetus in the guinea pig, J. Pathol. Bacteriol. 77:371.

    Article  PubMed  CAS  Google Scholar 

  21. Basten, A., Miller, J. F. A. P., Sprent, J., and Pye, J., 1972, Receptor for antigen-antibody complexes used to separate T cells from B cells, Nature (London) 235:178.

    CAS  Google Scholar 

  22. Basten, A., Sprent, J., and Miller, J. F. A. P., 1972, A receptor for antibody-antigen complexes on B cells: Its value in separating T cells from the lymphocyte population, Nature (London) New Biol. 235:178.

    CAS  Google Scholar 

  23. Beer, A. E., 1975, The cellular component of milk and its significance, Report of the 68th Ross Conference on Pediatric Research, p. 49, Ross Laboratories, Columbus, Ohio.

    Google Scholar 

  24. Benirschke, K., and Bourne, G. L., 1958, Plasma cells in an immature human placenta, Obstet. Gynecol. 12:495.

    PubMed  CAS  Google Scholar 

  25. Berg, T., 1968, Immunoglobulin levels in infants with low birth weights, Acta Paediatr. Scand. 57:369.

    Article  PubMed  CAS  Google Scholar 

  26. Berg, T., and Nilsson, B. O., 1969, The foetal development of serum levels of IgG and IgM, Acta Paediatr. Scand. 58:577.

    Article  PubMed  CAS  Google Scholar 

  27. Bertrams, J., Kuwert, E., and Lohmeyer, H. H., 1971, Die Spezifität von Leukozytenisoantikörpern zur Histokompatibilitätsbestimmung im Serum von Primi- und Multiparae, Bibl. Haematol. (Basel) 37:98.

    CAS  Google Scholar 

  28. Betke, K., 1972, Maternofetal transfusion; its incidence and clinical significance, Clinical conferences, XIVth International Congress of Haematology, Sao Paulo.

    Google Scholar 

  29. Black, M. M., and Speer, F. D., 1959, Lymph node reactivity. II. Fetal lymph nodes, Blood 14:848.

    PubMed  CAS  Google Scholar 

  30. Blanco, S., Blanco, A., and Sanchez Villares, E., 1973, B lymphocytes during childhood, Lancet 2:384.

    Article  PubMed  CAS  Google Scholar 

  31. Brambell, F. W. R., 1958, The passive immunity of the young mammal, Biol. Rev. 33:488.

    Article  Google Scholar 

  32. Brambell, F. W. R., 1966, The transmission of immunity from mother to young and the catabolism of immunoglobulins, Lancet 2:1087.

    Article  PubMed  CAS  Google Scholar 

  33. Brambell, F. W. R., and Halliday, R., 1956, The route by which passive immunity is transmitted from mother to foetus in the rat, Proc. R. Soc. Med. 145B:170.

    Google Scholar 

  34. Brandtzaeg, P., Fjellanger, J., and Gjeruldsen, S. T., 1967, Localization of immunoglobulins in human nasal mucosa, Immunochemistry 4:57.

    Article  PubMed  CAS  Google Scholar 

  35. Bridges, R. A., Condie, R. M., Zak, S. J., and Good, R. A., 1959, The morphologic basis of antibody formation development during the neonatal period, J. Lab. Clin. Med. 53:331.

    PubMed  CAS  Google Scholar 

  36. Brown, G., and Greaves, M. F., 1974, Enumeration of absolute numbers of T and B lymphocytes in human blood, Scand. J. Immunol. 3:161.

    Article  PubMed  CAS  Google Scholar 

  37. Brown, G., and Greaves, M. F., 1974, Cell surface markers for human T and B lymphocytes, Eur. J. Immunol. 4:302.

    Article  PubMed  CAS  Google Scholar 

  38. Brzezinski, A., Sadovsky, E., and Shafrir, E., 1964, Protein composition of early amniotic fluid and fetal serum with a case of bis-albuminemia, Amer. J. Obstet. Gynecol. 89:488.

    CAS  Google Scholar 

  39. Burttn, P., 1964, The immune sera and their utilization, in: Immunoelectrophoretic Analysis (P. Grabar and P. Burtin, eds.), p. 82, Elsevier Publishing Co., Amsterdam—London—New York.

    Google Scholar 

  40. Burtin, P., Guilbert, B., and Ternynck, T., 1960, A study of serum proteins related to immunity and their cellular origin, in: Ciba Found. Symp.: Cellular Aspects of Immunity (G. E. W. Wostenholme and M. O’Connor, eds.), p. 213, Churchill, London.

    Google Scholar 

  41. Carlsson, B., Ahlstedt, S., Hanson, L. Å., Lidin-Janson, G., Lindblad, B. S., and Sultana, R., 1976, Escherichia coli O antibody content in milk from healthy Swedish mothers and mothers from a very low socio-economic group of a developing country, Acta Paediatr. Scand. 65:417.

    Article  PubMed  CAS  Google Scholar 

  42. Carlsson, B., Gothefors, L., Ahlstedt, S., Hanson, L. Å., and Winberg, J., 1976, Studies of Escherichia coliO-antigen specific antibodies in human milk, maternal serum and cord blood, Acta Paediatr. Scand. 65:216.

    Article  PubMed  CAS  Google Scholar 

  43. Chandra, R. K., 1972, Immunocompetence in undernutrition, J. Pediatr. 81:1194.

    Article  PubMed  CAS  Google Scholar 

  44. Chandra, R. K., Guha, D. K., and Ghai, O. P., 1970, Serum immunoglobulins in the newborn, Indian J. Pediatr. 37:361.

    Article  PubMed  CAS  Google Scholar 

  45. Chodirker, W. B., and Tomasi, T. B., Jr., 1963, Gammaglobulins: Quantitative relationship in human serum and nonvascular fluids, Science 142:1080.

    Article  PubMed  CAS  Google Scholar 

  46. Christiansen, J. S., Osther, K., Peitersen, B., and Bach-Mortensen, N., 1976, B, T and null lymphocytes in newborn infants and their mothers, Acta Paediatr. Scand. 65:425.

    Article  PubMed  CAS  Google Scholar 

  47. Cochran, T. E.,. 1972, Fetal and maternal immunoglobulin concentrations at delivery and postpartum, J. Obstet. Gynaecol. Br. Commonw. 79:238.

    Article  PubMed  CAS  Google Scholar 

  48. Cohen, A., and Freeman, T., 1961, Metabolism of human -γ-globulins, in: Protides of the Biological Fluids (H. Peeters, ed.), 8th Colloquium, Bruges, 1960, Elsevier Publishing Co., Amsterdam.

    Google Scholar 

  49. Connon, A. F., 1970, Immunoglobulin levels for maternal and foetal serum, amniotic fluid and foetal gastric juice in normal pregnancy, Aust. J. Exp. Biol. Med. Sci. 48:691.

    Article  PubMed  CAS  Google Scholar 

  50. Corrodi, U., and Hitzig, W. H., 1973, Die pränatale Entwicklung det Immunglobuline, Monatsschr. Kinderheilkd. 121:1.

    PubMed  CAS  Google Scholar 

  51. Crabbé, P. A., Carbonara, A. O., and Heremans, J. F., 1963, The normal human intestinal mucosa as a majorsource of plasma cells containing γA-immunoglobulins, Lab. Invest. 14:235.

    Google Scholar 

  52. Cruchaud, A., Rosen, F. S., Craig, J. M., and Janeway, C. A., 1962, Site of synthesis of 19 S-γ-globulins in dysgammaglobulinemia, J. Exp. Med. 115:1141.

    Article  PubMed  CAS  Google Scholar 

  53. Csorba, S., 1968, Some facts on the problem of the appearance and quantitative relationship of the β 2 immune globulins, Helv. Paediatr. Acta 23:395.

    PubMed  CAS  Google Scholar 

  54. Dancis, J., 1952, Diphtheria antitoxin in mother and child in premature delivery, cited by Vahlquist, B., 1952, Placental transfer of antibodies in human beings, Etud. Néo-Natales 1:31.

    Google Scholar 

  55. Dancis, J., Braverman, N., and Lind, J., 1957, Plasma protein synthesis in the human fetus and in placenta, J. Clin. Invest. 36:398.

    Article  PubMed  CAS  Google Scholar 

  56. Dancis, J., Lind, J., and Vara, P., 1960, Transfer of proteins across the human placenta, in: The Placenta and Fetal Membranes (C. A. Villee, ed.), p. 185, Williams and Wilkins, Baltimore.

    Google Scholar 

  57. Dancis, J., Osborne, J. J., and Kunz, H. W., 1953, Studies of the immunology of the newborn infant, Pediatrics 12:151.

    PubMed  CAS  Google Scholar 

  58. Davies, A. J. S., 1969, The thymus and the cellular basis of immunity, Transplant. Rev. 1:43.

    PubMed  CAS  Google Scholar 

  59. Diaz-Jouanen, E. P., and William, R. C., Jr., 1974, T and B cells in human colostrum, Clin. Res. 22:416A.

    Google Scholar 

  60. Dürwald, W., Leopold, D., and Krämer, K.-H., 1965, The formation of precipitating antibodies after multiple pregnancies, Vox Sang. 10:94.

    Article  Google Scholar 

  61. Dwyer, J. M., and MacKay, I. R., 1970, Antigen-binding lymphocytes in human fetal thymus, Lancet 1:1199.

    Article  PubMed  CAS  Google Scholar 

  62. Edsall, G., 1956, Active and passive immunity of the infant, Ann. N. Y. Acad. Sci. 66:32.

    Article  PubMed  CAS  Google Scholar 

  63. Ehrlich, P., 1892, Über Immunität durch Vererbung und Säugung, Z. Hyg. Infektionskr. 12:183.

    Article  Google Scholar 

  64. Eichenwald, H. F., and Shinefield, H. R., 1963, Antibody production by the human fetus, J. Pediatr. 63:870.

    Google Scholar 

  65. Eitzman, D. V., 1964, Fate of defined antigens in the newborn chimpanzee, Pediatrics 34:787.

    PubMed  CAS  Google Scholar 

  66. Epstein, W. V., Fong, S. W., and Tan, M., 1966, Naturally occurring macroglobulin antibody of foetal origin in the normal human newborn, Immunology 10:259.

    PubMed  CAS  Google Scholar 

  67. Evans, D. G., and Smith, J. W. G., 1963, Response of the young infant to active immunization, Br. Med. Bull. 19:225.

    PubMed  CAS  Google Scholar 

  68. Evans, H. E., Akpata, S. O., and Glass, L., 1971, Serum immunoglobulin levels in premature and full-term infants, Amer. J. Clin. Pathol. 56:416.

    CAS  Google Scholar 

  69. Eyquem, A., Krieg, H., and Podliachouk, L., 1966, Anti-Gm and antiglobulinic antibodies after multiple pregnancies, Vox Sang. 11:623.

    Article  PubMed  CAS  Google Scholar 

  70. Fagraeus, A., 1948, Antibody production in relation to the development of plasma cells, Acta Med. Scand. Suppl. 204 130:3.

    Google Scholar 

  71. Fahey, J. L., and Lawrence, M. E., 1963, Quantitative determination of 6,6 S γ-globulins, β 2A-globu-lins and γ 1-macroglobulins in human serum, J. Immunol. 91:597.

    PubMed  CAS  Google Scholar 

  72. Faulk, W. P., van Loghem, E., and Stickler, G. B., 1974, Maternal antibody to fetal light chain (Inv) antigens, Amer. J. Med. 56:393.

    Article  PubMed  CAS  Google Scholar 

  73. Feldmann, M., 1972, Cell interactions in the immune response in vitro. II. The requirement for macrophages in lymphoid cell collaboration, J. Exp. Med. 135: 1049.

    Article  PubMed  CAS  Google Scholar 

  74. Ferguson, A. C., Lawlor, G. J., and Oh, W., 1974, Decreased rosette-forming lymphocytes in malnutrition and intrauterine growth retardation, J. Pediatr. 85:717.

    Article  PubMed  CAS  Google Scholar 

  75. Fink, C. W., and Lospalluto, J., 1964, Effect of prior administration of 7 S and 19 S antibody on active antibody formation, J. Pediatr. 65:1083.

    Article  Google Scholar 

  76. Fink, C. W., Miller, W. E., Dorward, B., and Lospalluto, J., 1962, The formation of macroglobulin antibodies. II. Studies on neonatal infants and older children, J. Clin. Invest. 41:1422.

    Article  PubMed  CAS  Google Scholar 

  77. Finkelstein, M. S., and Uhr, J. W., 1964, Specific inhibition of antibody formation by passively administered 19 S and 7 S antibody, Science 146:67.

    Article  PubMed  CAS  Google Scholar 

  78. Flexner, L. B., and Gellhorn, A., 1942, The comparative physiology of placental transfer, Amer. J. Obstet. Gynecol. 43:965.

    CAS  Google Scholar 

  79. Flexner, L. B., Cowie, D. B., Hellman, L. M., Wilde, W. S., and Vosburgh, G. J., 1948, The permeability of the human placenta to sodium in normal and abnormal pregnancies and the supply of sodium to the human fetus as determined with radioactive sodium, Amer. J. Obstet. Gynecol. 55: 469.

    CAS  Google Scholar 

  80. Frangione, B., Milstein, C., and Pink, J. R. L., 1969, Structural studies of immunoglobulin G, Nature (London) 221:145.

    Article  CAS  Google Scholar 

  81. Fröland, S. S., and Natvig, J. B., 1971, Classes and subclasses of surface-bound immunoglobulins on peripheral blood lymphocytes in man, in: Progress in Immunology (B. Amos, ed.), p. 107 Academic Press, New York.

    Google Scholar 

  82. Fröland, S. S., and Natvig, J. B., 1972, Lymphocytes with membrane-bound immunoglobulin (B-lymphocytes) in newborn babies, Clin. Exp. Immunol. 11:495.

    PubMed  Google Scholar 

  83. Fröland, S. S., and Natvig, J. B., 1972, Surface-bound immunoglobulin on lymphocytes from normal and immunodeficient humans, Scand. J. Immunol. 1:1.

    Article  PubMed  Google Scholar 

  84. Fröland, S. S., and Natvig, J. B., 1972, Class, subclass and allelic exclusion of membrane-bound Ig of human B lymphocytes, J. Exp. Med. 136:409.

    Article  PubMed  Google Scholar 

  85. Fröland, S. S., Natvig, J. B., and Berdal, P., 1971, Surface-bound immunoglobulin as a marker of B lymphocytes in man, Nature (London) New Biol. 234:251.

    Google Scholar 

  86. Fudenberg, H. H., 1971, Immunoglobulins: Structure, function and genetic control, in: Immunologic Incompetence (B. M. Kagan and R. E. Stiehm, eds.), p. 17, Year Book Medical Publishers, Chicago.

    Google Scholar 

  87. Fudenberg, H. H., and Fudenberg, B. Roof, 1964, Antibody to hereditary human gammaglobulin (Gm). Factor resulting from maternal-fetal incompatibility, Science 145:170.

    Article  PubMed  CAS  Google Scholar 

  88. Fulginiti, V. A., Sieber, O. F., Claman, H. N., and Merrill, D., 1966, Serum immunoglobulin measurement during the first year of life and in immunoglobulin-deficiency states, J. Pediatr. 68:723.

    Article  PubMed  CAS  Google Scholar 

  89. van Fürth, R., Schuit, H. R. E., and Hijmans, W., 1965, The immunological development of the human fetus, J. Exp. Med. 122:1173.

    Article  PubMed  Google Scholar 

  90. Gairdner, D., Marks, J., and Roscoe, J. D., 1952, Blood formation in infancy, Arch. Dis. Child. 27:128.

    Article  PubMed  CAS  Google Scholar 

  91. Gindrat, J. J., Gothefors, L., Hanson, L. Å., and Winberg, J., 1972, Antibodies in human milk against E. coli of the serogroups most commonly found in neonatal infections, Acta Paediatr. Scand. 61:587.

    Article  PubMed  CAS  Google Scholar 

  92. Gitlin, D., 1971, Development and metabolism of the immune globulins, in: Immunologic Incompetence (B. M. Kagan and R. E. Stiehm, eds.), p. 3, Year Book Medical Publishers, Chicago.

    Google Scholar 

  93. Gitlin, D., Kumate, J., Urrusti, J., and Morales, C., 1964, The selectivity of the human placenta in the transfer of plasma proteins from mother to fetus, J. Clin. Invest. 43:1938.

    Article  PubMed  CAS  Google Scholar 

  94. Goldblum, R. M., Ahlstedt, S., Carlsson, B., and Hanson, L. Å., 1975, Antibody production by human colostrum cells, Pediatr. Res. 9:330.

    Google Scholar 

  95. Good, R. A., Varco, R. L., Aust, J. B., and Zak, S. J., 1957, Transplantation studies in patients with agammaglobulinemia, Ann. N. Y. Acad. Sci. 64:882.

    Article  PubMed  CAS  Google Scholar 

  96. Gothefors, L., Carlsson, B., Ahlstedt, S., Hanson, L. Å., and Windberg, J., 1976, Influence of maternal gut flora and colostral and cord serum antibodies on presence of Escherichia coli in faeces of the newborn infant, Acta Paediatr. Scand. 65:225.

    Article  PubMed  CAS  Google Scholar 

  97. Gotoff, S. P., and Cochrane, W. D., 1968, Antibody response to the somatic antigens of Salmonella Newport in pemature infants, Pediatrics 37:610.

    Google Scholar 

  98. Greaves, M. F., Owen, J. J. T., and Raff, M. C., 1974, T and B Lymphocytes: Origins, Properties and Roles in Immune Responses, Exerpta Medica, Amsterdam, and American Elsevier Publishing Co., New York.

    Google Scholar 

  99. Gugler, E., 1970, Das exokrine IgA-System beim Menschen, Habilitationsschrift, Bern.

    Google Scholar 

  100. Gugler, E., Bokelmann, G., Dättwyler, A., and von Muralt, G., 1958, Über immunoelektrophore-tische Untersuchungen an Frauenmilchproteinen, Schweiz. Med. Wochenschr. 88:1264.

    PubMed  CAS  Google Scholar 

  101. Gudson, J. P., 1969, Fetal and maternal immunoglobulin levels during pregnancy, Amer. J. Obétet. Gynecol. 103:895.

    Google Scholar 

  102. Hall, J. G., and Smith, M. E., 1970, Homing of lymph-borne immunoblasts to the gut, Nature (London) 226:262.

    Article  CAS  Google Scholar 

  103. Hanson, L. Å., 1959, Immunological analysis of human milk, Int. Arch. Allergy 15:245.

    Article  PubMed  CAS  Google Scholar 

  104. Hanson, L. Å., 1973, Zur immunologischen Bedeutung der Frauenmilch, Pädiatr. Fortbildungskurse Praxis 37:1.

    CAS  Google Scholar 

  105. Hanson, L. Â., and Brandtzaeg, P., 1973, Secretory antibody-system, in: Immunologie Disorders in Infants and Children (E. R. Stiehm and V. A. Fulginiti, eds.), p. 107, W. B. Saunders Co., Philadelphia-London-Toronto.

    Google Scholar 

  106. Hanson, L. Å., and Johansson, B. G., 1970, Immunological studies of milk, in: Milk Proteins. Chemistry and Molecular Biology (H. A. McKenzie, ed.), Vol. I, p. 45, Academic Press, New York and London.

    Google Scholar 

  107. Hanson, L. Ä., and Winberg, J., 1972, Breast milk and defense against infection in the newborn, Arch. Dis. Child. 47:845.

    Article  PubMed  CAS  Google Scholar 

  108. Haworth, J. C., and Dilling, L., 1966, Concentration of IgA-globulin in serum, saliva and nasopharyngeal secretions of infants and children, J. Lab. Clin. Med. 67:922.

    PubMed  CAS  Google Scholar 

  109. Haworth, J. C., Norris, M., and Dilling, L., 1965, A study of the immunoglobulins in premature infants, Arch. Dis. Child. 40:243.

    Article  PubMed  CAS  Google Scholar 

  110. Hayward, A. R., and Ezer, G., 1974, Development of lymphocyte populations in the human foetal thymus and spleen, Clin. Exp. Immunol. 17:169.

    PubMed  CAS  Google Scholar 

  111. Hayward, A. R., and Soothill, J. E., 1972, Reaction to antigen by human foetal thymus lymphocytes, in: Ciba Found. Symp.: Ontogeny of Acquired Immunity (R. Porter and J. Knight, eds.), p. 261, Elsevier—Excerpta Medica—North-Holland.

    Google Scholar 

  112. Hazenberg, B. P., 1968, Gastrointestinal excretion of serum proteins. An investigation on the excretion of serum proteins in the gastrointestinal tract and the production of immunoglobulins in the jejunal wall, Thesis, Groningen.

    Google Scholar 

  113. Heimlich, E. M., Benis, M., and Busser, R. J., 1964, Immunoglobulin levels of maternal-cord blood pairs. Quoted in V. A. Fulginiti, O. F. Sieber, H. N. Claman, and D. Merrill, 1966, Serum immunoglobulin measurement during the first year of life and in immunoglobulin deficiency states, J. Pediatr. 68:723.

    Google Scholar 

  114. Heremans J. F., and Vaerman, J. P., 1971, Biological significance of IgA antibodies in serum and secretions, in: Progress in Immunology (B. Amos, ed.), p. 875, Academic Press, New York.

    Google Scholar 

  115. Hiramoto, R. N., and Hamlin, M., 1965, Detection of two antibodies in single plasma cells by paired fluorescence technique, J. Immunol. 95:214.

    PubMed  CAS  Google Scholar 

  116. Hirvonen, T., Rossi, T., and Toivanen, P., 1969, Cord IgG and duration of labour, Lancet 1:315.

    Article  PubMed  CAS  Google Scholar 

  117. Hitzig, W. H., 1960, Praktische und theoretische Ergebnisse neuerer Bluteiweissuntersuchungen, Schweiz. Med. Wochenschr. 90:1449.

    PubMed  CAS  Google Scholar 

  118. Hobbs, J. R., and Davis, J. A., 1967, Serum γG-globulin levels and gestational age in premature babies, Lancet 1:757.

    Article  PubMed  CAS  Google Scholar 

  119. Hobbs, J. R., Hughes, M. J., and Walker, W., 1968, Immunoglobulin levels in infants after intrauterine transfusion, Lancet 1:1400.

    Article  PubMed  CAS  Google Scholar 

  120. Holborow, E. J., 1967, An ABC of modern immunology, Lancet 1:829ff.

    Google Scholar 

  121. Hong, R., and Ammann, A. J., Lymphocytes and delayed hypersensitivity, in: Immunologic Disorders in Inf ants and Children (E. R. Stiehm and V. A. Fulginiti, eds.), p. 16, W. B. Saunders Co., Philadelphia— London—Toronto.

    Google Scholar 

  122. Hošková, A., Rozprimová, L., Hlavoň, J., and Pátková, P., 1975, Perinatal immunoglobulin levels in premature and small-for-date infants, Z. Kinderheilkd. 119:217.

    Article  PubMed  Google Scholar 

  123. Humpherey J. H., and Batty, I., 1974, International reference preparation for human Serum IgG, IgA, IgM, Clin. Exp. Immunol. 17:708.

    Google Scholar 

  124. Hyslop, N. F., and Kern, K., 1973, Physiology of human breast function: Regulation of immunoglobulin secretion into colostrum and breast milk, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 32:1035.

    Google Scholar 

  125. Hyslop, N., and Walker, A., 1975, Importance of nursing in passive intestinal immunity, Report of the 68th Ross Conference on Pediatric Research, p. 44, Ross Laboratories, Columbus, Ohio.

    Google Scholar 

  126. Ishizaka, K., and Ishizaka, T., 1971, Immunoglobulin E and homocytotropic properties, in: Progress in Immunology (B. Amos, ed.), p. 859, Academic Press, New York.

    Google Scholar 

  127. Isomäki, A. M., 1973, A new cell type (tuft cell) in the gastro-intestinal mucosa of the rat, Acta Pathol. Microbiol. Scand. Sect. A Suppl. 240.

    Google Scholar 

  128. Iyengar, L., and Selvaraj, R. J., 1972, Intestinal absorption of immunoglobulins by newborn infants, Arch. Dis. Child. 47:411.

    Article  PubMed  CAS  Google Scholar 

  129. Jacobson, E. B., and Herzenberg, L. A., 1972, Active suppression of immunoglobulin allotype synthesis. I. Chronic suppression after perinatal exposure to maternal antibody to paternal allotype in mice, J. Exp. Med. 135:1151.

    Article  PubMed  CAS  Google Scholar 

  130. Jacobson, E. B., Herzenberg, A. L., Riblet, R., and Herzenberg, L. A., 1972, Active suppression of immunoglobulin allotype synthesis. II. Transfer with spleen cells, J. Exp. Med. 135:1163.

    Article  PubMed  CAS  Google Scholar 

  131. Johansson, S. G. O., 1968, Serum IgND levels in healthy children and adults, Int. Arch. Allergy 34:1.

    Article  PubMed  CAS  Google Scholar 

  132. Johansson, S. G. O., and Bennich, H., 1967, Studies on a new class of human immunoglobulins. I. Immunological properties, Nobel Symp. 3:193.

    Google Scholar 

  133. Johansson, S. G. O., and Berg, T., 1967, Immunoglobulin levels in healthy children, Acta Paediatr. Scand. 56:572.

    Article  PubMed  CAS  Google Scholar 

  134. Johansson, S. G. O., Bennich, H., and Wide, L., 1968, A new class of immunoglobulin in human serum, Immunology 14:265.

    PubMed  CAS  Google Scholar 

  135. Johansson, S. G. O., Mellbin, T., and Vahlquist, B., 1968, Immunoglobulin levels in Ethiopian preschool children with special reference to high concentrations of immunoglobulin E (IgND), Lancet 1:1118.

    Article  PubMed  CAS  Google Scholar 

  136. Jondal, M., Wigzell, H., and Aiuti, F., 1973, Human lymphocyte subpopulations: Classification according to surface markers and/or functional characteristics, Transplant. Rev. 16:163.

    PubMed  CAS  Google Scholar 

  137. Jones, W. R., 1969, Immunoglobulins in fetal serum, J. Obstet. Gynaecol. Br. Commonw. 76:41.

    Article  PubMed  CAS  Google Scholar 

  138. Jones, W. R., 1972, Cord serum immunoglobulin levels in “small-for-dates”babies, Aust. Paediatr. J. 8:30.

    PubMed  CAS  Google Scholar 

  139. Jones, W. R., and Payne, R. B., 1967, Effect of mode of delivery on immunoglobulin G concentration in the newborn, Amer. J. Obstet. Gynecol. 99:1160.

    Google Scholar 

  140. Joppich, G., and Lissens, P., 1937, Knochenmarksuntersuchungen beim lebenden Säugling, Monatsschr. Kinderheilkd. 71:382.

    Google Scholar 

  141. Kay, H. E. M., 1971, Lymphocyte function. Annotation, Br. J. Haematol, 20:139.

    Article  PubMed  CAS  Google Scholar 

  142. Keller, R., Dwyer, J. E., William, O. H., and D’Amodio, M., 1969, Intestinal IgA neutralizing antibodies in newborn infants following poliovirus immunization, Pediatrics 43:330.

    PubMed  CAS  Google Scholar 

  143. Kenny, J. F., Boesman, M. J., and Michaels, R. H., 1967, Bacterial and viral coproantibodies in breast-fed infants, Pediatrics 39:202.

    PubMed  CAS  Google Scholar 

  144. Kinkade, P. W., and Cooper, M. D., 1971, Development and distribution of immunoglobulin-containing cells in the chicken, J. Immunol. 106:371.

    Google Scholar 

  145. Khadraoui, S., Lopez, V., Hamza, B., and Smith, N. J., 1977, L’immunité cellulaire au cours de la malnutrition protéino-calorique, Arch. Franç. Péd. 34:143.

    CAS  Google Scholar 

  146. Kohler, F., and Farr, R. S., 1966, Elevation of cord maternal IgG immunoglobulin: Evidence for an active placental IgG transport, Nature (London) 210:1070.

    Article  CAS  Google Scholar 

  147. Koltay, M., and Jllyés, M., 1966, A study of immunoglobulins in the blood serum of infants with interstitial plasma cellular pneumonia, Acta Paediatr. Scand. 55:489.

    Article  PubMed  CAS  Google Scholar 

  148. Krähenbühl, J. P., and Campiche, M. A., 1969, Early stages of intestinal absorption of specific antibodies in the newborn. An ultrastructural, cytochemical and immunological study in the pig, rat and rabbit, J. Cell. Biol. 42:345.

    Article  Google Scholar 

  149. Kuttner, A., and Ratner, B., 1923, The importance of colostrum to the newborn infant, Amer. J. Dis. Child. 25:413.

    Google Scholar 

  150. Lambotte, R., and Salmon J., 1962, Etude immuno-électrophorétique du liquide amniotique humain, C. R. Séances Soc. Biol. Paris 156:530.

    CAS  Google Scholar 

  151. Lambotte, R., and Salmon, J., 1962, Passage du liquide amniotique dans la circulation maternelle lors de l’accouchement, C. R. Séances Soc. Biol. Paris 156:1187.

    CAS  Google Scholar 

  152. Lambotte, R., and SalmonJ., 1963, Etude immuno-électrophorétique du liquide amniotique du lapin, C. R. Séances Soc. Biol. Paris 157:1849.

    CAS  Google Scholar 

  153. Lamy, M., Nezelof, C., Seligman, M., and Griscelli, C., 1966, L’acquisition de l’immunité chez l’enfant, Minerva Pediatr. 18:1579.

    PubMed  CAS  Google Scholar 

  154. Lawton, A. R., and Cooper, M. D., 1973, Development of immunity: Phylogeny and ontogeny, in: Immunologic Disorders in Infants and Children (E. R. Stiehm and V. A. Fulginiti, eds.), p. 28, W. B. Saunders Co., Philadelphia—London— Toronto.

    Google Scholar 

  155. Lawton, A. R., Self, K. S., Royal, S. A., and Cooper, M. D., 1972, Ontogeny of B-lymphocytes in the human fetus, Clin. Immunol. Immunopathol. 1:84.

    Article  Google Scholar 

  156. Leading article, 1975, Immunological tolerance, Lancet 1:555.

    Google Scholar 

  157. De Lemos, L., and Gautier, E., 1972, Influence de la rupture prolongée des membranes et des infections de la période néonatale sur les IgM sériques du nouveauné, Schweiz. Med. Wochenschr. 102:505.

    PubMed  Google Scholar 

  158. Leslie, G. A., and Swate, T. E., 1972, Structure and biologic functions of human IgD. I. The presence of immunoglobulin D in human cord sera, J. Immunol. 109:47.

    PubMed  CAS  Google Scholar 

  159. Lev, R., and Orlic, D., 1973, Uptake of protein in swallowed amniotic fluid by monkey fetal intestine in utero, Gastroenterology 65:60.

    PubMed  CAS  Google Scholar 

  160. Liebermann, R., and Dray, S., 1964, Maternal-fetal mortality in mice with isoantibodies to paternal γ-globulin allotypes, Proc. Soc. Exp. Biol Med. 116:1069.

    Google Scholar 

  161. Locke, R. F., Segre, D., and Myers, W. L., 1964, The immunologic behavior of baby pigs. IV. Intestinal absorption and persistence of 6,6 S and 18 S antibodies of ovine origin and their role in immunologic competence of baby pigs, J. Immunol. 93: 576.

    PubMed  CAS  Google Scholar 

  162. Lodinova, R., and Wagner, V., 1971, Immunoglobulins and coproantibodies after oral colonization (E. coli), in: Immunologic Incompetence (B. M. Kagan and E. R. Stiehm, eds.), p. 61, Year Book Medical Publishers, Chicago.

    Google Scholar 

  163. Mage, R., and Dray, S., 1965, Persistent altered phenotypic expression of allelic γG-immunoglobulin allotypes in heterozygous rabbits exposed to isoantibodies in fetal and neonatal life, J. Immunol. 95: 525.

    PubMed  CAS  Google Scholar 

  164. Marchalonis, J., and Edelman, G. M., 1965, Phylogenetic origins of antibody structure. I. Multichain structure of immunoglobulins in the smooth dogfish (Mustelus canis), J. Exp. Med. 122:601.

    Article  PubMed  CAS  Google Scholar 

  165. Mârtensson, L., and Fudenberg, H. H., 1965, Gm genes and γG-globulin synthesis in the human fetus, J. Immunol. 94:514.

    Google Scholar 

  166. Mathews, J. D., McKay, I. R., Whittingham, S., and Malcolm, L. A., 1972, Protein supplementation and enhanced antibody-producing capacity in New Guinean school-children, Lancet 2:675.

    Article  PubMed  CAS  Google Scholar 

  167. McCracken, G. H., and Shinefield, H. R., 1965, Immunoglobulin concentration in newborn infants with congenital cytomegalic inclusion disease, Pediatrics 36:933.

    PubMed  Google Scholar 

  168. McFarlane, H., and Udeozo, J. O. K., 1968, Immunochemical estimation of some proteins in Nigerian paired maternal and fetal blood, Arch. Dis. Child. 43:42.

    Article  PubMed  CAS  Google Scholar 

  169. McKay, E., and Thom, H., 1971, Antibodies to gamma globulin in pregnant women: Incidence, aetiology and size, J. Obstet. Gynaecol. Br. Commonw. 78:345.

    Article  PubMed  CAS  Google Scholar 

  170. McKay, E., Thom, H., and Gray, D., 1967, Immunoglobulins in umbilical cord plasma. II. Congenital deformities, other abnormalities and multiple pregnancies, Arch. Dis. Child. 42:264.

    Article  PubMed  CAS  Google Scholar 

  171. Mellits, E. D., 1971, Relationship between cord serum immunoglobulin levels and later abnormalities. Is neonatal screening for IgM a worth-while procedure?, Johns Hopkins Med. J. 128:306.

    PubMed  CAS  Google Scholar 

  172. Mellors, R. C., and Korngold, L., 1963, The cellular origin of human immunoglobulins (γ 2, γ1m, γ1A), J. Exp. Med. 118:387.

    Article  PubMed  CAS  Google Scholar 

  173. Mendenhall, H. W., 1970, Serum protein concentrations in pregnancy. III. Analysis of maternal-cord serum pairs, Amer. J. Obstet. Gynecol. 106:718.

    CAS  Google Scholar 

  174. Mentasti, P., 1960, Valutazione elettroforetica delle protéine délia membrana amniotica. Considerazioni sulla genesi dei protidi del liquido amniotico, Minerva Ginecol. 12:276.

    CAS  Google Scholar 

  175. Michael, J. G., Ringenback, R., and Hottenstein, S., 1971, The antimicrobial activity of human colostral antibody in the newborn, J. Infect. Dis. 124:445.

    Article  PubMed  CAS  Google Scholar 

  176. Michaux, J. L., 1966, Les immunoglobulines des Bantoux à l’état normal et pathologique, Ann. Soc. Belg. Méd. Trop. 46:491.

    Google Scholar 

  177. Miller, J. F. A. P., 1966, Immunity in the foetus and the newborn, Br. Med. Bull. 22:21.

    PubMed  CAS  Google Scholar 

  178. Mitchell, G. F., Mishel, R. J., and Herzenberg, L. A., 1971, Studies on the influence of T-cells in antibody production, in: Progress in Immunology, First International Congress of Immunology, Academic Press, New York.

    Google Scholar 

  179. Mitchison, N. A., 1961, Immunological tolerance and immunological paralysis, Br. Med. Bull. 17:102.

    PubMed  CAS  Google Scholar 

  180. Mitchison, N. A., 1964, Induction of immunological paralysis in two zones of dosage, Proc. R. Soc. London Ser. B 161:275.

    Article  CAS  Google Scholar 

  181. Mohr, J. A., Leu, R., and Mabry, W., 1970, Colostral leucocytes, J. Surg. Oncol. 2:163.

    Article  PubMed  CAS  Google Scholar 

  182. Mohr, R., 1975, Über Funktionen von B- und T-Zellen, in: Lymphozyt und klinische Immunologie (H. Theml and H. Begemann, eds.), p. 27, Springer-Verlag, Berlin—Heidelberg—New York.

    Chapter  Google Scholar 

  183. Möller, G., and Wigzell, H., 1965, Antibody synthesis at the cellular level: Antibody-induced suppression of 19 S and 7 S antibody response, J. Exp. Med. 121:969.

    Article  PubMed  Google Scholar 

  184. Morell, A., Skvaril, F., and Barandun, S., 1975, IgG-Subklassen der menschlichen Immunglobuline. Immunochemische, genetische, biologische und klinische Aspekte, S. Karger, Basel—Munich—Paris—London—New York—Sydney.

    Google Scholar 

  185. Morell, A., Skvaril, F., Hitzig, W. H., and Barandun, S., 1972, IgG subclasses: Development of the serum concentrations in “normal” infants and children, J. Pediatr. 80:960.

    Article  PubMed  CAS  Google Scholar 

  186. Morell, A., Skvaril, F., van Loghem, E., and Kleemola, M., 1971, Human IgG subclasses in maternal and fetal serum, Vox Sang. 21:481.

    Article  PubMed  CAS  Google Scholar 

  187. Morris, J. G., 1958, The effects of heterologous sera on the uptake of rabbit antibody from the gut of young mice, Proc. R. Soc. London Ser. B 148: 84.

    Article  CAS  Google Scholar 

  188. Morris, J. G., 1963, Transmission of anti-Brucella abortus agglutinins across the gut in young mice, Nature (London) 197:813.

    Article  Google Scholar 

  189. Morris, J. G., 1963, Interference with the uptake of guinea pig agglutinins in mice due to fractions of papain hydrolyzed rabbit γ-globulin, Proc. R. Soc. London Ser. B 157:160.

    Article  Google Scholar 

  190. Morris, J. G., 1964, The transmission of antibodies and normal γ-globulins across the young mouse gut, Proc. R. Soc. London Ser. B 160:276.

    Article  CAS  Google Scholar 

  191. de Muralt, G., 1962, La Maturation de l’Immunité Humorale chez l’Homme, Benno Schwabe & Co., Basel and Stuttgart.

    Google Scholar 

  192. de Muralt, G., 1970, Immunoglobulins in the human fetus and newborn, in: Physiology of the Perinatal Period (U. Stave, ed.), Vol. I, p. 323, Appleton-Century-Crofts, New York.

    Google Scholar 

  193. de Muralt, G., 1972, Die klinische Bedeutung der immunologischen Wechselbeziehungen zwischen Mutter und Kind, Paediatr. Fortbildungskurse Praxis 35:24.

    Google Scholar 

  194. de Muralt, G., 1975, Immunologische Beziehungen zwischen Mutter und Kind. Eine Übersicht, Geburtshilfe. Frauenheilkd. 35:583.

    PubMed  CAS  Google Scholar 

  195. de Muralt, G., and Gugler, E., 1959, Die Reifung der Immunglobuline, Helv. Med. Acta 26:410.

    Google Scholar 

  196. de Muralt, G., and Roulet, D. L. A., 1961, Etude immunologique des protéines sériques foetales humaines, Helv. Paediatr. Acta 16:517.

    PubMed  CAS  Google Scholar 

  197. de Muralt, G., and Roulet, D. L. A., 1962, Recherches immunologiques sur les protéines foetales, en particulier sur une globuline spécifique du foetus humain, in: Protides of the Biological Fluids (H. Peeters, ed.), 9th Colloquium, Bruges, 1961, Elsevier Publishing Co., Amsterdam.

    Google Scholar 

  198. de Muralt, G., Gugler, E., and Roulet, D. L. A., 1964, Immuno-electrophoretic studies of the proteins of human milk and colostrum, in: Immunoelectro-phoretic Analysis (P. Grabar and P. Burtin, eds.), p. 261, Elsevier Publishing Co., Amsterdam-London—New York.

    Google Scholar 

  199. Murillo, G. J., 1971, Synthesis of secretory IgA by human colostral cells, South. Med. J. 64:1333.

    Article  PubMed  CAS  Google Scholar 

  200. Murillo, G. J., and Goldman, A. S., 1970, The cells of human colostrum. II. Synthesis of IgA and β 1C, Pediatr. Res. 4:71.

    Article  PubMed  CAS  Google Scholar 

  201. Nathenson, G., Schorr, J. B., and Litwin, S. D., 1971, Gm factor fetomaternal gamma globulin incompatibility, Pediatr. Res. 5:2.

    Article  Google Scholar 

  202. Nejedla, A., 1967, Über den Einfluss wiederholter Gaben von γ-globulin auf die Antikörperbildung bei Säuglingen, Monatsschr. Kinderheilkd. 115:333.

    PubMed  CAS  Google Scholar 

  203. Nejedlá, A., 1970, The development of immunological factors in infants with hyperbilirubinemia, Pediatrics 45:102.

    PubMed  Google Scholar 

  204. Nezelof, G., and Diebold, J., 1975, Le tissu lymphatique, in: Encyclopédie Médico-Chirurgicale, Vol. I, Sang et Organes Hématopoïétiques, Editions Techniques, Paris.

    Google Scholar 

  205. Nordbring, F., 1957, The appearance of antistreptolysin and antistaphylolysin in human colostrum, Acta Paediatr. Scand. 46:481.

    Article  Google Scholar 

  206. Nossal, G. J. V., 1958, Antibody production by single cells, Br. J. Exp. Pathol. 39:544.

    PubMed  CAS  Google Scholar 

  207. Nossal, G. J. V., 1959, Antibody production by single cells. II. The difference between primary and secondary response, Br. J. Exp. Pathol. 40:118.

    PubMed  CAS  Google Scholar 

  208. Nossal, G. J. V., 1960, Antibody production by single cells. IV. Further studies on multiply immunized animals, Br. J. Exp. Pathol. 41:89.

    PubMed  CAS  Google Scholar 

  209. Nossal, G.J. V., 1971, Recent advances in immunological tolerance, in: Progress in Immunology (B. Amos, ed.), p. 665, Academic Press, New York.

    Google Scholar 

  210. Nossal, G. J. V., and Mitchell, J. M., 1966, The thymus in relation to immunological tolerance, in: Ciba Foundation Symposium on the Thymus: Experimental and Clinical Studies (G. E. W. Wostenholme and R. Porter, eds.), p. 105, Churchill, London.

    Google Scholar 

  211. Nossal, G. J. V., Szenberg, A., Ada, G. L., and Austin, C. M., 1964, Single cell studies on 19 S antibody production, J. Exp. Med. 119:485.

    Article  PubMed  CAS  Google Scholar 

  212. Overweg, J., and Engelfried, C. P., 1969, Cytotoxic leucocyte isoantibodies formed during the first pregnancy, Vox Sang. 16:97.

    Article  PubMed  CAS  Google Scholar 

  213. Pagano, J. S., Plotkin, S. A., and Cornely, D., 1964, The response of premature infants to infection with type 3 attenuated poliovirus, J. Pediatr. 65:165.

    Article  PubMed  CAS  Google Scholar 

  214. Page, E. W., 1957, Transfer of materials across the human placenta, Amer. J. Obstet. Gynecol. 74:705.

    CAS  Google Scholar 

  215. Papadatos, C., Papaevangelou, G., Alexiou, D., and Mendris, J., 1969, Immunoglobulin levels and gestational age, Biol. Neonate 14:365.

    Article  CAS  Google Scholar 

  216. Papaevangelou, G., Alexiou, D., and Papadatos, C., 1973, Les immunoglobulines M et A chez le nouveau-né normal et dysmature (small-for-date), Ann. Pediatr. 20:187.

    Google Scholar 

  217. Papiernik, M., 1970, Correlation of lymphocyte transformation and morphology in the human fetal thymus, Blood 36:470.

    PubMed  CAS  Google Scholar 

  218. Payne, R. B., 1969, Cord IgG and duration of labour, Lancet 1:372.

    Article  PubMed  CAS  Google Scholar 

  219. Peitersen, B., Bohn, L., and Andersen, H., 1975, Quantitative determination of immunoglobulins, lysozyme, and certain electrolytes in breast milk during the entire period of lactation, during a 24-hour period and in milk from the individual mammary gland, Acta Paediatr. Scand. 64:709.

    Article  PubMed  CAS  Google Scholar 

  220. Pernis, B., Ferrarini, M., Forni, L., and Amante, L., 1971, Immunoglobulins on lymphocyte membranes, First International Congress of Immunology 1971, p. 95, Academic Press, New York.

    Google Scholar 

  221. Pernis, B., Forni, L., and Amante, L., 1971, Immunoglobulins as cell receptors, Ann. N. Y. Acad. Sci. 190:420.

    Article  PubMed  CAS  Google Scholar 

  222. Piessens, W. F., Schur, P. H., Miloney, W. C., and Churchill, W. H., 1973, Lymphocyte surface immunoglobulins. Distribution and frequency in lymphoproliferative diseases, N. Engl. J. Med. 288:176.

    Article  PubMed  CAS  Google Scholar 

  223. Pilgrim, U., Fontanellaz, H. P., Evers, G., and Hitzig, W. H., 1975, Normal values of immunoglobulins in premature and full-term infants, calculated in percentiles, Helv. Paediatr. Acta 30:121.

    PubMed  CAS  Google Scholar 

  224. Pirofsky, B., Davies, G. H., Ramirez-Mateos, J. C., and Newton, B. W., 1973, Cellular immune competence in the human fetus, Cell. Immunol. 6:324.

    Article  PubMed  CAS  Google Scholar 

  225. Playfair, J. H. L., Wolfendale, M. R., and Kay, H. E. M., 1963, The leucocytes of the peripheral blood in the human foetus, Br. J. Haematol. 9:336.

    Article  PubMed  CAS  Google Scholar 

  226. Polano, O., 1904, Der Antitoxinübergang von der Mutter auf das Kind, Z. Geburtshilfe Gynaekol. 53:456.

    Google Scholar 

  227. Polliack, A., Lampen, N., Clarkson, B. D., and de Harven, E., 1973, Identification of human B and T lymphocytes by scanning electron microscopy, J. Exp. Med. 138:607.

    Article  PubMed  CAS  Google Scholar 

  228. Prindull, G., 1974, Maturation of cellular and humoral immunity during human embryonic development, Acta Paediatr. Scand. 63:607.

    Article  PubMed  CAS  Google Scholar 

  229. Provenzano, R. W., Wetterlow, L. H., and Sullivan, C. L., 1965, Immunization and antibody response in the newborn infant. 1. Pertussis inoculation within twenty-four hours of birth, N. Engl. J. Med. 273:959.

    Article  PubMed  CAS  Google Scholar 

  230. Quinlivan, L. G., 1964, Transplacental passage of gamma-globulin-I131 in the rat, Amer. J. Physiol. 207:782.

    PubMed  CAS  Google Scholar 

  231. Quinlivan, L. G., 1964, Antepartum and postpartum transfer of gamma globulin I131 in the rat, Amer. J. Physiol 207:787.

    PubMed  CAS  Google Scholar 

  232. Rabellino, E., Colon, S., Grea, H. M., and Unanue, E. R., 1971, Immunoglobulins on the surface of lymphocytes. I. Distribution and quantitation, J. Exp. Med. 133:156.

    Article  PubMed  CAS  Google Scholar 

  233. Rauer, U., and Freund, R., 1969, Normalwerte von Immunglobulinen im Kindesalter, Monatsschr. Kinderheilkd. 117:559.

    PubMed  CAS  Google Scholar 

  234. Recommendations for the Nomenclature of Human Immunoglobulins (editorial), 1972, J. Immunol. 108:1733.

    Google Scholar 

  235. Remington, J. S., Miller, M. J., and Brownlee, J., 1968, IgM antibodies in acute toxoplasmosis. I. Diagnostic significance in congenital cases and a method for their rapid demonstration, Pediatrics 41:1082.

    PubMed  CAS  Google Scholar 

  236. Remington, J. S., Vosti, K. L., Lietze, A., and Zimmerman, A. L., 1964, Serum proteins and antibody activity in human nasal secretions, J. Clin. Invest. 43:1613.

    Article  PubMed  CAS  Google Scholar 

  237. Robbins, J. B., Kenny, K., and Suter, E., 1965, Isolation and biological activities of rabbit yM- and γG-anti-Salmonella typhimurium antibodies, J. Exp. Med. 122:385.

    Article  PubMed  CAS  Google Scholar 

  238. Roelants, G., Forni, L., and Pernis, B., 1973, Blocking and redistribution (“capping”) of antigen receptors on T and B lymphocytes by antiimmunoglobulin antibody, J. Exp. Med. 137:1060.

    Article  PubMed  CAS  Google Scholar 

  239. Rogentine, G. N., Rowe, D. S., Bradley, J., Waldmann, T. A., and Fahey, J. L., 1966, Metabolism of human immunoglobulin D (IgD), J. Clin. Invest. 45:1467.

    Article  PubMed  CAS  Google Scholar 

  240. Roit, I. M., Greaves, M. F., Torrigiani, G., Brostoff, J., and Playfair, J. H. L., 1969, The cellular basis of immunological responses, Lancet 2:367.

    Article  Google Scholar 

  241. Ropartz, C., Rivat, L., and Rousseau, P. Y., 1965, La transmission des facteurs Gm et Inv de la mère à l’enfant nouveau-né, Ann. Génét. 8:39.

    PubMed  CAS  Google Scholar 

  242. Rosen, F. S., 1974, Immunity in the fetus and newborn, in: Modern Perinatal Medicine (Gluck, ed.), p. 273, Year Book Medical Publishers, Chicago.

    Google Scholar 

  243. Rosen, F. S., and Janeway, C. A., 1966, The gamma globulins. III. The antibody deficiency syndromes, N. Engl. J. Med. 275:709.

    Article  PubMed  CAS  Google Scholar 

  244. Rosenberg, M., 1969, Fetal hematopoiesis. Case report, Blood 33:66.

    PubMed  CAS  Google Scholar 

  245. Roth, N., 1962, Zur semiquantitativen Erfassung der beiden Serum-Immunglobuline Beta2A und Beta2M im Neugeborenen und Kindesalter, Ann. Paediatr. (Basel) 199:548.

    CAS  Google Scholar 

  246. Rothberg, R. M., 1969, Immunoglobulin and specific antibody synthesis during the first weeks of life of premature infants, J. Pediatr. 75:391.

    Article  PubMed  CAS  Google Scholar 

  247. Rowe, D. S., and Fahey, J. L., 1965, A new class of human immunoglobulins. I. A unique myeloma protein, J. Exp. Med. 121:171.

    Article  PubMed  CAS  Google Scholar 

  248. Rowe, D. S., and Fahey, J. L., 1965, New class of human immunoglobulins. II. Normal serum IgD, J. Exp. Med. 121:185.

    Article  PubMed  CAS  Google Scholar 

  249. Rowe, D. S., Hug, K., and Faulk, W. P., 1973, IgD on the surface of peripheral blood lymphocytes on the human newborn, Nature (London) New Biol. 242:155.

    Article  CAS  Google Scholar 

  250. Rowe, D. S., McGregor, I. A., Smith, S. J., Hall, P., and Williams, K., 1968, Plasma immunoglobulin concentrations in a West African (Gambian) community and in a group of healthy British adults, Clin. Exp. Immunol. 3:63.

    PubMed  CAS  Google Scholar 

  251. Rubaltelli, F. F., Piovesan, A. L., Semenzato, G. P., Barbato, A., and Ongaro, G., 1977, Immune competence assessment in hyperbilirubinemic newborns before and after phototherapy, Helv. Paediatr. Acta 32:129.

    PubMed  CAS  Google Scholar 

  252. Ruckstuhl, J., 1970, Titerverlauf und hämolytische Späteffekte der Rhesusantikörper bei Austauschtransfusion bei Neugeborenen mit rhesusbedingter hämolytischer Anämie, Helv. Paediatr. Acta 25:258.

    PubMed  CAS  Google Scholar 

  253. Sahiar, K., and Schwartz, R. S., 1965, The immunoglobulin sequence. 1. Arrest by 6-mercap-topurine and restitution by antibody, antigen or splenectomy, J. Immunol. 95:345.

    PubMed  CAS  Google Scholar 

  254. Salmon, J., Lambotte, R., and Smoliar, V., 1962, Etude par immunofluorescence de la sécrétion du liquide amniotique humain, Arch. Int. Physiol. Biochim. 70:731.

    Article  PubMed  CAS  Google Scholar 

  255. Di Sant’Agnese, P. A., 1949, Combined immunization against diphtheria, tetanus and pertussis in newborn infants; duration of antibody levels; antibody titers after booster dose; effect of passive immunity to diphtheria on active immunization with diphtheria toxoid, Pediatrics 3:181.

    Google Scholar 

  256. Schneegans, E., Heumann, G., de Muralt, G., Bütler, R., and Geisert, J., 1968, Etude comparée des immunoglobulines des prématurés élevés en service semi-stérile et en service normal, Ann. Pédiatr. 15:642.

    CAS  Google Scholar 

  257. Schneegans, E., de Muralt, G., Bütler, R., Heumann, G., and Geisert, J., 1966, Immunologische Probleme beim Frühgeborenen, Acta Paediatr. Acad. Sci. Hung. 7:213.

    PubMed  CAS  Google Scholar 

  258. Schneegans, E., Rohmer, A., de Muralt, G., Heumann, G., Haarscher, A., Cohen, A., and Cronmuller, G., 1969, Alimentation des prématurés au lait de femme et au colostrum, Rapport 22e Congrès Assoc. Pédiatres langue française, Strasbourg 1969 (Expansion scientifique française Paris 1969), p. 173.

    Google Scholar 

  259. Schubert, J., and Grünberg, A., 1949, Zur Frage der Übertragung von Immunantikörpern von der Mutter auf das Kind, Schweiz. Med. Wochenschr. 79:1007.

    PubMed  CAS  Google Scholar 

  260. Schultze, H. E., and Heremans, J. F., 1966, Molecular Biology of Human Proteins, Vol. 1, Elsevier Publishing Co., Amsterdam—London—New York.

    Google Scholar 

  261. Seigler, H. F., and Metzgar, R. S., 1970, Embryonic development of human transplantation antigens, Transplantation 9:478.

    Article  PubMed  CAS  Google Scholar 

  262. Sidiropoulos, D., 1975, Personal communication.

    Google Scholar 

  263. Sieber, O. F., Jr., Fulginiti, V. A., Brazie, J., and Umlauf, H. J., 1966, In utero infection of fetus by herpes simplex virus, J. Pediatr. 69:30.

    Article  PubMed  Google Scholar 

  264. Silverstein, A. M., 1962, Congenital syphilis and the timing of immunogenesis in the human foetus, Nature (London) 194:196.

    Article  CAS  Google Scholar 

  265. Skoog, V. T., Weber, T. H., and Richter, W., 1974, Studies on the interaction between mitogens and human lymphocytes in vitro, Exp. Cell Res. 85:339.

    Article  PubMed  CAS  Google Scholar 

  266. Slater, R. J., 1954, Investigation of an infant born of a mother suffering from cirrhosis of the liver, Pediatrics 13:308.

    PubMed  CAS  Google Scholar 

  267. Smith, C. W., and Goldman, A. S., 1968, The cells of human colostrum. I. In vitro studies of morphology and functions, Pediatr. Res. 2:103.

    Article  PubMed  CAS  Google Scholar 

  268. Smith, R. T., 1960, Response to active immunization of human infants during the neonatal period, in: Ciba Foundation Symposium on Cellular Aspects of Immunity (G. E. W. Wostenholme and M. O’Connor, eds.), p. 348, Churchill, London.

    Google Scholar 

  269. Smith, R. T., 1964, Immunologic tolerance: Developmental phenomenon, Pediatrics 34:14.

    PubMed  Google Scholar 

  270. Smith, R. T., Eitzman, D. V., Catlin, M. E., Wirtz, E. O., and Miller, B. E., 1964, The development of the immune response. Characterization of the response of the human infant and adult to immunization with Salmonella vaccines, Pediatrics 33:163.

    PubMed  CAS  Google Scholar 

  271. Smythe, P. M., Brereton-Stiles, G. G., Grace, H. J., Mafoyane, A., Schonland, M., Coovadia, H. M., Loening, W. E. K., Parent, M. A., and Vos, G. H., 1971, Thymolymphatic deficiency and depression of cell-mediated immunity in protein-calorie malnutrition, Lancet 2:939.

    Article  PubMed  CAS  Google Scholar 

  272. Solomon, J.B., 1971, Foetal and Neonatal Immunology, North-Holland Publishing Co., Amsterdam and London.

    Google Scholar 

  273. Speiser, P., 1963, Über Antikörperbildung von Säuglingen und Kleinkindern gegen mütterliches γ2-globulin. Ein bisher unbekanntes, dem Erythro-blastenmechanismus konträres Phänomen mit anscheinend immunogenetisch obligatem Charakter, Wien. Med. Wochenschr. 113:966.

    PubMed  CAS  Google Scholar 

  274. Stege, N., and Gugler, E., 1968, Die quantitative Bestimmung der Immunglobulinreifung mit Hilfe einer einfachen radialen Immunodiffusionsmethode, Helv. Paediatr. Acta 22:242.

    Google Scholar 

  275. Stiehm, E. R., 1973, Immunoglobulins and antibodies, in: Immunologic Disorders in Infants and Children (E. R. Stiehm and V. A. Fulginiti, eds.), p. 42, W. B. Saunders Co., Philadelphia—London-Toronto.

    Google Scholar 

  276. Stiehm, E. R., and Fudenberg, H. H., 1966, Serum levels of immune globulins in health and diseases. A survey, Pediatrics 37:715.

    PubMed  CAS  Google Scholar 

  277. Stiehm, E. R., Ammann, A. J., and Cherry, J. D., 1966, Elevated cord macroglobulins in the diagnosis of intrauterine infections, N. Engl. J. Med. 275:971.

    Article  PubMed  CAS  Google Scholar 

  278. Stites, D. P., Carr, M. C., and Fudenberg, H. H., 1974, Ontogeny of cellular immunity in the human fetus. Development of responses to phytohemag-glutinin and to allogenic cells, Cell. Immunol. 11:257.

    Article  PubMed  CAS  Google Scholar 

  279. Stites, D. P., Wybran, J., Carr, M. C., and Fudenberg, H. H., 1972, Development of cellular immunocompetence in man, in: Ciba Found. Symp.: Ontogeny of Acquired Immunity (R. Porter and J. Knight, eds.), p. 113, Elsevier-Excerpta Medica-North-Holland.

    Google Scholar 

  280. Stollar, O. A., Pelley, R. P., Kaniecki-Green, E., Klaus, M. H., and Carpenter, C. L. J., 1976, Secretory IgA against enterotoxins in breast-milk, Lancet 1:1258.

    Article  Google Scholar 

  281. Stulberg, C. S., Zuelzer, W. W., and Page, R. H., 1956, Escherichia coli 0 127:B 8, a serotype causing infantile diarrhea. III. The antibody response of infants, J. Immunol. 76:281.

    PubMed  CAS  Google Scholar 

  282. Terry, W. D., 1965, Skin-sensitizing activity related to γ-polypeptide chain characteristics of human IgG, J. Immunol. 95:1041.

    PubMed  CAS  Google Scholar 

  283. Terry, W. D., and Fahey, J. L., 1964, Subclasses of human γ 2-globulin based on differences in heavy polypeptide chains, Science 146:400.

    Article  PubMed  CAS  Google Scholar 

  284. Thom, E., McKay, E., and Gray, D., 1967, Immunoglobulins in umbilical cord plasma. I. Healthy infants, Arch. Dis. Child. 42:259.

    Article  PubMed  CAS  Google Scholar 

  285. Thomas, D. B., and Yoffey, J. M., 1962, Human foetal haematopoiesis. I. The cellular composition of fetal blood, Br. J. Haematol. 8:290.

    Article  PubMed  CAS  Google Scholar 

  286. Thorley, J. D., Holmes, R. K., Kaplan, J. M., McCracken, G. H., and Sanford, J. P., 1975, Passive transfer of antibodies of maternal origin from blood to cerebrospinal fluid in infants, Lancet 1:651.

    Article  PubMed  CAS  Google Scholar 

  287. Tomasi, T. B., Jr., and Zigelbaum, S., 1963, Selective occurrence of γ1A-globulins in certain body fluids, J. Clin. Invest. 42:1552.

    Article  PubMed  CAS  Google Scholar 

  288. Tomasi, T. B., Tan, E. M., Solomon, A., and Prendergast, R. A., 1965, Characteristics of immune system common to certain external secretions, J. Exp. Med. 121:101.

    Article  PubMed  CAS  Google Scholar 

  289. Tongio, M. M., and Mayer, S., 1963, Immunisation foeto-maternelle anti-HL-A Passage des anticorps anti-HL-A de la mère à l’enfant, Nouv. Rev. Fr. Hématol. 13:181.

    Google Scholar 

  290. Turmero, J. A., 1974, Antibody transfer during labor, Amer. J. Obstet. Gynecol. 119:486.

    CAS  Google Scholar 

  291. Trepel, F., 1975, Kinetik lymphatischer Zellen, in: Lymphozyt und klinische Immunologie (H. Theml and H. Begemann, eds.), p. 16, Springer-Verlag, Berlin— Heidelberg—New York.

    Chapter  Google Scholar 

  292. Trevorrow, V. E., 1959, Concentration of gammaglobulin in the serum of infants during the first 3 months of life, Pediatrics 24:746.

    PubMed  CAS  Google Scholar 

  293. Ugazio, A. G., Marcioni, A. F., Astaldi, A. J., and Burgio, G. R., 1974, Peripheral blood B lymphocytes in infancy and childhood, Acta Paediatr. Scand. 63:205.

    Article  PubMed  CAS  Google Scholar 

  294. Uhr, J. W., Dancis, J., Franklin, E. C., Finkelstein, M. S., and Lewis, E. W., 1962, The antibody response to bacteriophage 0X 174 in newborn premature infants, J. Clin. Invest. 41:1509.

    Article  PubMed  CAS  Google Scholar 

  295. Unanue, E. R., Grey, H. M., Rabellino, E., Campbell, P., and Schmidtke, J., 1971, Immunoglobulins on the surface of lymphocytes. II. The bone marrow as the main source of lymphocytes with detectable surface-bound immunoglobulin, J. Exp. Med. 133:1188.

    Article  PubMed  CAS  Google Scholar 

  296. Ungar, J., 1956, Les anticorps chez l’enfant, Sem. Hop. Paris (Pathol. Biol) 5:1105.

    Google Scholar 

  297. Vahlquist, B., 1958, The transfer of antibodies from mother to offspring, Adv. Pediatr. 10:305.

    Google Scholar 

  298. Vierucci, A., Pedone, S., and Morgese, G., 1967, L’isoimmunizatione materno-fetale verso fattori ereditari plasmatici, in: Proceedings of Symposium on Problems of Fetal Distress, Siena, 16–18 Sept. 1966 (A. Centaro and F. Ragazzini, eds.), p. 713, Piccin Edition, Padova.

    Google Scholar 

  299. Vierucci, A., Varone, D., and Ingiulla, A., 1964, La sintesi delle Immunoglobuline del tipo IgG (7 S) nel periodo feto-neonatale studiata mediante l’im-pegio dei marcatori genetici Gm, Riv. Clin. Pediatr. 74:505.

    PubMed  CAS  Google Scholar 

  300. Virella, G., de Paschle, A., and Lippi, U., 1971, Placenta transfer of human IgG2 macroclonal protein, Experientia 27:324.

    Article  PubMed  CAS  Google Scholar 

  301. Vorherr, H., 1974, The Breast: Morphology, Physiology and Lactation, Academic Press, New York—San Francisco—London.

    Google Scholar 

  302. Vyas, G. N., Levin, A. S., and Fudenberg, H. H., 1970, Intrauterine isoimmunization caused by maternal IgA crossing the placenta, Nature (London) 225:275.

    Article  CAS  Google Scholar 

  303. Vyas, G. N., Perkins, H. A., and Fudenberg, H. H., 1938, Anaphylactoid transfusion reactions associated with anti-IgA, Lancet 2:312.

    Google Scholar 

  304. Waldmann, T. A., Strober, W., and Blaese, R. M., 1971, Metabolism of immunoglobulins, in: Progress in Immunology (B. Amos, ed.), p. 891, Academic Press, New York.

    Google Scholar 

  305. Walsh, S. Z., and Lind, J., 1970, The dynamics of the foetal heart and circulation and its alteration at birth, in: Physiology of the Perinatal Period (U. Stave, ed.), Vol. I, p. 161, Appleton-Century-Crofts, New York.

    Google Scholar 

  306. Wang, A. C., Faulk, W. P., Stuckey, M. A., and Fudenberg, H. H., 1970, Chemical differences of adult, fetal and hypogammaglobulinemic IgG immunoglobulins, Immunochemistry 7:703.

    Article  PubMed  CAS  Google Scholar 

  307. Weber, T. H., Skoog, V. T., Mattsson, A., and Lindahl-Kiessling, K., 1974, Kinetics of lymphocyte stimulation in vitro by non-specific mitogens, Exp. Cell Res. 85:351.

    Article  PubMed  CAS  Google Scholar 

  308. Werder-Kind, H., 1963, Das Serumeiweissbild beim Frühgeborenen, Helv. Paediatr. Acta 18:450.

    PubMed  CAS  Google Scholar 

  309. West, C. D., Hong, R., and Holland, N. H., 1962, Immunoglobulin levels from the newborn period to adulthood and in immunoglobulin deficiency states, J. Clin. Invest. 41:2054.

    Article  PubMed  CAS  Google Scholar 

  310. Wilson, J. A., and Steinberg, A., 1965, Antibodies to gamma globulin in the serum of children and adults, Transfusion (Philadelphia) 5:516.

    Article  CAS  Google Scholar 

  311. White, R. G., 1958, Antibody production by single cells, Nature (London) 182:1383.

    Article  CAS  Google Scholar 

  312. WHO, 1964, Nomenclature for human immunoglobulins, Bull WHO 30:447.

    Google Scholar 

  313. WHO, 1974, Identification, enumeration and isolation of B and T lymphocytes from human peripheral blood, Report of a WHO/IARC-Sponsored workshop on human B and T cells, London, 15–17 July 1974, Scand. J. Immunol 3:521.

    Article  Google Scholar 

  314. Wirtschafter, Z. T., 1958, Free amino acids in human amniotic fluid, fetal and maternal serum, Amer. J. Obstet. Gynecol. 76:1219.

    CAS  Google Scholar 

  315. Wislocki, G. B., 1955, Comparative anatomy and histology of the placental barrier, in: Gestation (L. B. Flexner, ed.), Transactions of the 1st conference, p. 219, Josiah Macy Foundation, New York.

    Google Scholar 

  316. Wybrand, J., Carr, M. C., and Fudenberg, H. H., 1972, The human rosette-forming cell as a marker of a population of thymus-derived cells, J. Clin. Invest. 51:2537.

    Article  Google Scholar 

  317. Xanthou, M., 1970, Leucocyte blood picture in healthy full-term and premature babies during neonatal period, Arch. Dis. Child. 45:242.

    Article  PubMed  CAS  Google Scholar 

  318. Yang, S. L., Kleinmann, A. M., and Wei, P. Y., 1971, The effect of labor and mode of delivery on immunoglobulin concentrations in the neonate, Amer. J. Obstet. Gynecol 109:78.

    CAS  Google Scholar 

  319. Yeager, A. S., 1973, Variation of cord IgM level with birth weight, Pediatrics 51:616.

    PubMed  CAS  Google Scholar 

  320. Yeung, C. Y., and Hobbs, J. R., 1968, Serum yG-globulin levels in normal, premature, postmature and “small-for-dates” newborn babies, Lancet 1:1167.

    Article  PubMed  CAS  Google Scholar 

  321. Yoffey, J. M., and Thomas, D. B., 1964, The development of bone marrow in the human foetus, J. Anat. 98:463.

    Google Scholar 

  322. Zak, S. J., and Good, R. A., 1959, Immunochemical studies of human serum gamma globulins, J. Clin. Invest. 38:579.

    Article  PubMed  CAS  Google Scholar 

  323. Zimmermann, A., Brun des Re, G., Bürki, H., Keller, H.-U., Hess, M. W., and Cottier, H., 1975, Lymphozytenformen—Morphologische und funktionelle Charakterisierungsmöglichkeiten, Herkunft und Entwicklung, in: Lymphozyt und klinische Immunologie (H. Theml and H. Begemann, eds.), p. 2, Springer-Verlag, Berlin—Heidelberg—New York.

    Chapter  Google Scholar 

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  1. Department of Perinatology, University Women’s Hospital, Bern, Switzerland

    Gaspard de Muralt

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  1. Mailman Center for Child Development, University of Miami Medical School, USA

    Uwe Stave

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de Muralt, G. (1978). Maturation of Cellular and Humoral Immunity. In: Stave, U. (eds) Perinatal Physiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2316-7_14

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