Skip to main content

Two Decades of Experience in the Treatment of Paget’s Disease of Bone with Plicamycin (Mithramycin)

  • Chapter
Paget’s Disease of Bone

Abstract

Although Sir James Paget described the bone disease bearing his name in 1876, almost a century elapsed before effective therapies were developed. Now there are several and effective treatment of most if not all patients with the disorder will likely be possible within the next several years. Thus within the past 20 years, rapid strides have been made in our understanding of and ability to manage this disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ryan WG, Schwartz TB, Perlia CP: Effects of mithramycin on Paget’s disease of bone. Ann Intern Med 1969; 70: 549–557.

    PubMed  CAS  Google Scholar 

  2. Kennedy BJ: Metabolic and toxic effects of mithramycin during tumor therapy. Am J Med 1970; 49: 494–503.

    Article  PubMed  CAS  Google Scholar 

  3. Monto RS, Talley RW, Caldwell MJ, et al: Observations on the mechanism of hemorrhagic toxicity in mithramycin therapy. Cancer Res 1969; 29: 697–704.

    PubMed  CAS  Google Scholar 

  4. Kofman S, Eisenstein R: Mithramycin in the treatment of disseminated cancer. Cancer Chemother 1963; 32: 77.

    CAS  Google Scholar 

  5. Kofman S, Medrek TJ, Alexander RW: Mithramycin in treatment of embryonal cancer. Cancer 1964; 17: 938–948.

    Article  PubMed  CAS  Google Scholar 

  6. Brown JH, Kennedy BJ: Mithramycin in the treatment of disseminated testicular neoplasms. N Engl J Med 1965; 272: 111–118.

    Article  PubMed  CAS  Google Scholar 

  7. Ream NW, Perlia CP, Wolter J, Taylor SG III: Mithramycin therapy in disseminated germinal testicular cancer. JAMA 1968; 204: 1030–1036.

    Article  PubMed  CAS  Google Scholar 

  8. Rebel A, Malkani K, Basle M: Particularités ultrastructurales des osteoclasts de la maladie de Paget. Rev Rhum Mal Osteo-Articulaires 1974; 41: 767–771.

    CAS  Google Scholar 

  9. Mills BG, Singer FR: Nuclear inclusions in Paget’s disease of bone. Science 1976; 194: 201–202.

    Article  PubMed  CAS  Google Scholar 

  10. Eisenstein R, Passavoy M: Actinomycin D inhibits parathyroid hormone and vitamin D activity. Proc Soc Exp Biol Med 1964; 117: 77–79.

    PubMed  CAS  Google Scholar 

  11. Rasmussen H, Arnaud C, Hawker C: Actinomycin D and response to parathyroid hormone. Science 1964; 154: 1019–1021.

    Article  Google Scholar 

  12. Fennelly JJ: Clinical and biochemical studies of Paget’s disease of bone with emphasis on the effects of RNA inhibitors actinomycin D and mithramycin. Ir J Med Sci 1971; 140: 431–448.

    Article  PubMed  CAS  Google Scholar 

  13. Parsons V, Baum M, Self M: Effects of mithramycin on calcium and hydroxyproline metabolism in patients with malignant disease. Br Med J 1967; 1: 474–477.

    Article  PubMed  CAS  Google Scholar 

  14. Perlia CP, Gubisch NJ, Wolter J, et al: Mithramycin treatment of hypercalcemia. Cancer 1970; 25: 389–394.

    Article  PubMed  CAS  Google Scholar 

  15. Ryan WG, Schwartz TB, Northrop G: Experiences in the treatment of Paget’s disease of bone with mithramycin. JAMA 1970; 213: 1153–1157.

    Article  PubMed  CAS  Google Scholar 

  16. Ryan WG, Schwartz TB, Northrop G: Treatment of Paget’s disease with mithramycin: Further experiences. Semin Drug Treat 1972; 2: 57–64.

    PubMed  CAS  Google Scholar 

  17. Ryan WG: Treatment of Paget’s disease of bone with mithramycin. Clin Orthop 1977; 127: 106–110.

    PubMed  Google Scholar 

  18. Condon JR, Reith SBM, Nassim JR, et al: Treatment of Paget’s disease of bone with mithramycin. Br Med J 1971; 1: 421–423.

    Article  PubMed  CAS  Google Scholar 

  19. Elias EG, Evans JT: Mithramycin in the treatment of Paget’s disease of bone. J Bone Joint Surg 1972; 54: 1730–1736.

    PubMed  CAS  Google Scholar 

  20. Aitken JM, Lindsey R: Mithramycin in Paget’s disease. Lancet 1973; 1: 1177.

    Article  PubMed  CAS  Google Scholar 

  21. Eisinger JB, Recordier AM: Traitment de la maladie de Paget par la mithramycine. Lyon Med 1975; 11: 627–629.

    Google Scholar 

  22. Russell AS, Lentle BC: Mithramycin therapy in Paget’s disease. Can Med Assoc J 1974; 110: 397–400.

    PubMed  CAS  Google Scholar 

  23. Russell AS, Chalmers IM, Percy JS, Lentle BC: Long term effectiveness of low dose mithramycin for Paget’s disease of bone. Arthritis Rheum 1979; 22: 215–218.

    Article  PubMed  CAS  Google Scholar 

  24. Heath DA: The role of mithramycin in the management of Paget’s disease. Metab Bone Dis 1981,4,5:343–345.

    Article  Google Scholar 

  25. Condon JR, Surtees J, Robinson V: Control of osteitis deformans using glucagon, calcitonin and mithramycin. Postgrad Med J 1981; 57: 84–88.

    Article  PubMed  CAS  Google Scholar 

  26. Hadjipavlou AG, Tsoukas GM, Siller TN, et al: Combination drug therapy in treatment of Paget’s disease of bone. J Bone Joint Surg 1977; 59; 1 (A): 1045–1051.

    PubMed  CAS  Google Scholar 

  27. Pembrook RC, Chung CH, Carvallo AP: Effects of mithramycin and calcitonin in cardiovascular complications of Paget’s disease of bone. Conn Med 1975; 39: 209–214.

    PubMed  CAS  Google Scholar 

  28. Theil GB, Ajlouni K: Mithramycin effects on calcium phosphorus and parathyroid hormone in osseous Paget’s disease. Am J Med Sci 1975; 269: 13–18.

    Article  PubMed  Google Scholar 

  29. Ajlouni K, Theil GB: Effect of mithramycin on hydroxyproline metabolism in Paget’s disease. J Lab Clin Med 1977; 90: 803–808.

    PubMed  Google Scholar 

  30. Ryan WG, Schwartz TB, Fordham EW: Mithramycin and long remission of Paget’s disease of bone. Ann Intern Med 1980; 92: 129.

    PubMed  CAS  Google Scholar 

  31. Lebbin D, Ryan WG, Schwartz TB: Outpatient treatment of Paget’s disease of bone with mithramycin. Ann Intern Med 1974; 81: 635–637.

    PubMed  CAS  Google Scholar 

  32. Ryan WG, Schwartz TB: Mithramycin treatment of Paget’s disease of bone: Exploration of combined mithramycin-EHDP therapy. Arthritis Rheum 1980; 23: 1155–1161.

    Article  PubMed  CAS  Google Scholar 

  33. Ahn YS, Harrington WJ: Clinical uses of macrophage inhibitors. Adv Intern Med 1980; 25: 453–473.

    PubMed  CAS  Google Scholar 

  34. Ahn YS, Harrington WJ, Mylvaganam R, et al: Slow infusion of vinca alkaloids in the treatment of idiopathic thrombocytopenic purpura. Ann Intern Med 1984; 100: 192–196.

    PubMed  CAS  Google Scholar 

  35. Owen M: The origin of bone cells in the postnatal organism. Arthritis Rheum 1980; 23: 1073–1077.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Elsevier Science Publishing Co., Inc.

About this chapter

Cite this chapter

Ryan, W.G. (1991). Two Decades of Experience in the Treatment of Paget’s Disease of Bone with Plicamycin (Mithramycin). In: Singer, F.R., Wallach, S. (eds) Paget’s Disease of Bone. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2307-5_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-2307-5_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2309-9

  • Online ISBN: 978-1-4684-2307-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics