Abstract
Recent neurophysiological studies in primates have increased significantly our knowledge of neural pathways that play a role in pain sensation and reaction. In the peripheral nervous system, neural populations have been identified which respond exclusively to intense or noxious stimuli applied to the skin (Burgess & Perl, 1973). Similarly, some neurons in the spinal cord dorsal horn with axon projections to the thalamus respond only to tissue-threatening or tissue-damaging stimuli (Willis, Trevino, Coulter, and Maunz, 1974; Price and Mayer, 1975). However, the situation is complicated by the finding that many spinothalamic neurons have a wide dynamic response range to innocuous and noxious mechanical stimuli (Willis et al, 1974; Price and Mayer, 1975). What role do such neurons play in pain? Furthermore, all of these studies have been performed under general anesthesia or after surgical brain lesions, both of which alter ongoing and evoked central neuronal activity. For example, dorsal horn neurons activated by noxious mechanical stimulation in a spinalized cat do not respond to similar stimuli in a decerebrated animal (Brown, 1971). Other studies have shown that cold block of the cervical spinal cord in anesthetized cats results in a significant increase in the sensitivity of lumbar spinal cord dorsal horn neurons to noxious heat stimuli (Zimmermann and Handwerker, 1974). Since the responsivity of these neurons is dependent upon the waking state of the animal, only tentative conclusions can be drawn from such experiments about the functional role of different spinal cord populations in pain.
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References
Burgess, P.R. and Perl, E.R.: Cutaneous mechanoreceptors and nociceptors. In: Handbook of Sensory Physiology, Somatosensory System, edited by A. Iggo, Heidelberg: Springer-Verlag, 1973, 2:29–78.
Brown, A.G.: Effects of descending impulses on transmission through the spinocervical tract. J. Physiol., London, 1971, 219:103–125.
Campbell, B.A. and Church, R.M. (eds.): Punishment and Aversive Behavior, New York: Appleton-Century-Crofts, 1969.
Campbell, B.A. and Masterson, F.A. : Psychophysics of Punishment. In: Punishment and Aversive Behavior, edited by B.A. Campbell and R.M. Church, New York: Appleton-Century-Crofts, 1969, p. 3–42.
Casey, K.L., Keene, J.J., and Morrow, T.: Bulborecticular and medial thalamic unit activity in relation to aversive behavior and pain. In: Advances in Neurology, Pain, edited by John J. Bonica. New York: Raven, 1974, 4:197–205.
Dubner, R., Sumino, R., and Starkman, S.: Responses of facial cutaneous thermosensitive and mechanosensitive afferent fibers in the monkey to noxious heat stimulation. In: Advances in Neurology, Pain, edited by John J. Bonica. New York: Raven, 1974, 4:61–71.
Hardy, J.D., Goodell, H., and Wolff, H.G.: The influence of skin temperature upon the pain threshold as evoked by thermal radiation. Science, 1951, 114: 149–150.
Hardy, J.D., Jacobs, I., and Meinner, M.D.: Thresholds of pain and reflex contraction as related to noxious stimulation. J. Appl. Physiol., 1953, 5:725–739.
Hardy, J.D., Wolff, H.G., and Goodell, H.: Pain Sensations and Reactions. Baltimore: Williams and Wilkins, 1952.
Manning, A.A. and Vierck, C.J., Jr.: Behavioral assessment of pain detection and tolerance in monkeys. J. Exp. Anal. Behav., 1973, 19:125–132.
McKenna, A.E.: The experimental approach to pain. J. Appl. Physiol., 1958, 13:449–456.
Melzack, R. and Casey, K.L.: Sensory, motivational and central control determinants of pain. In: The Skin Senses, edited by D.R. Kenshalo. Springfield: Thomas, 1968, p. 423–439.
Neisser, U.: Temperature thresholds for cutaneous pain. J. Appl. Physiol., 1959, 14:368–372.
Price, D.D. and Mayer, D.J.: Neurophysiological characterization of the anterolateral quadrant neurons subserving pain in M. Mulatta. Pain, 1975, 1:59–72.
Vierck, C.J. Jr., Hamilton, D.M., and Thornby, J.I.: Pain reactivity of monkeys after lesions to the dorsal and lateral columns of the spinal cord. Exp. Brain Res., 1971, 13:140–158.
Willis, W.D., Trevino, D.L., Coulter, J.D., and Maunz, R.A.: Responses of primate spinothalamic tract neurons to natural stimulation of hindlimb. J. Neurophysiol., 1974, 37:358–372.
Zimmermann, M. and Handwerker, H.O.: Total afferent inflow and dorsal horn activity upon radiant heat stimulation to the cat’s footpad. In: Advances in Neurology, Pain, edited by John J. Bonica, New York, Raven, 1974, 4:29–33.
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© 1976 Plenum Press, New York
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Dubner, R., Beitel, R.E., Brown, F.J. (1976). A Behavioral Animal Model for the Study of Pain Mechanisms in Primates. In: Weisenberg, M., Tursky, B. (eds) Pain. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2304-4_13
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DOI: https://doi.org/10.1007/978-1-4684-2304-4_13
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