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Biochemical Aspects

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Book cover Principles of Surgical Oncology

Abstract

Since the earliest observation of the London surgeon, Percivall Pott, in the eighteenth century that contact with soot was associated with scrotal skin cancer in chimney sweeps, a wide variety of agents causing cancer have been discovered. These include an extensive number and variety of organic chemicals, metals, oncogenic viruses, ultraviolet light, X-rays, and other ionizing radiations, which may singly and in various combinations result in malignancies of many different types. The epidemiology of cancer suggests that a high proportion of human malignancies are environmental in origin, as for example the lung cancer due to cigarette smoking, the bladder cancer of chemical workers using 2-naphthylamine or benzidine, and the liver cancer due to eating food contaminated with aflatoxins or nitrosamines. Furthermore, although the importance of radiations and oncogenic viruses in the causation of human cancer should in no way be discounted or minimized, it would seem nevertheless that chemicals comprise the major cause (Miller, 1970; Miller and Miller, 1971; Weisburger and Williams, 1975).

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  1. Department of Biochemistry, University of Surrey, Guildford, Surrey, GU2 5XH, England

    Dennis V. Parke

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  1. Royal College of Surgeons of England, London, England

    Ronald W. Raven O.B.E., T.D. (Former Member of Council, Consulting Surgeon) (Former Member of Council, Consulting Surgeon)

  2. Royal Marsden Hospital and Institute of Cancer Research, London, England

    Ronald W. Raven O.B.E., T.D. (Former Member of Council, Consulting Surgeon) (Former Member of Council, Consulting Surgeon)

  3. Westminster Hospital, London, England

    Ronald W. Raven O.B.E., T.D. (Former Member of Council, Consulting Surgeon) (Former Member of Council, Consulting Surgeon)

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Parke, D.V. (1977). Biochemical Aspects. In: Raven, R.W. (eds) Principles of Surgical Oncology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2301-3_7

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