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Developmental Biology Related to Oncology

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Book cover Principles of Surgical Oncology

Abstract

Research in perinatal tumor induction experienced a new impetus in past years through several important discoveries in experimental chemical and viral oncogenesis. The following discoveries probably had the greatest impact: (1) The experimental proof that leukemia tumor viruses can be transmitted in rodents by infection from animal to animal, i.e., horizontal transmission, but also by inheritance of the viral genome from generation to generation, i.e., vertical transmission. (2) The successful transplacental induction of various organ tumors in rodents by alkylating chemical carcinogens (Mohr and Althoff, 1964, 1965; Druckrey et al., 1966). (3) The discovery of the high susceptibility of rat fetuses to the oncogenic effect of ethylnitrosourea (Ivankovic and Druckrey, 1968).

The research for this chapter was supported in part by Deutsche Forschungsgemeinschaft and National Institutes of Health Grant CA 11224.

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Authors and Affiliations

  1. Max-Planck-Institut für Hirnforschung, Abteilung für Allgemeine Neurologie, Ostmerheimer Strasse 200, D 5000, Köln 91, West Germany

    Wolfgang Wechsler

  2. Department of Veterinary Pathobiology, The Ohio State University, 1925 Coffey Road, Columbus, Ohio, 43210, USA

    Adalbert Koestner

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  1. Wolfgang Wechsler
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  1. Royal College of Surgeons of England, London, England

    Ronald W. Raven O.B.E., T.D. (Former Member of Council, Consulting Surgeon) (Former Member of Council, Consulting Surgeon)

  2. Royal Marsden Hospital and Institute of Cancer Research, London, England

    Ronald W. Raven O.B.E., T.D. (Former Member of Council, Consulting Surgeon) (Former Member of Council, Consulting Surgeon)

  3. Westminster Hospital, London, England

    Ronald W. Raven O.B.E., T.D. (Former Member of Council, Consulting Surgeon) (Former Member of Council, Consulting Surgeon)

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Wechsler, W., Koestner, A. (1977). Developmental Biology Related to Oncology. In: Raven, R.W. (eds) Principles of Surgical Oncology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2301-3_6

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