Abstract
It is generally conceded that the cancer pattern in a population is determined to a large extent by its physical, biological, and human environment and that most racial differences are the result of these external factors. Some rare tumors, such as the squamous cell carcinoma that develops in the skin of individuals with xeroderma pigmentosa or the adenocarcinoma of the large bowel in patients with familial polyposis, clearly have a strong genetic component. Genetic factors may also play a role in determining which individuals in a population develop a tumor when exposed to a specific environmental hazard. Solar keratosis and squamous cell carcinoma of the skin which occurs as a result of ultraviolet irradiation is closely related to the degree of skin pigmentation. The albino African represents the highest risk, while the normal dark skinned African is completely immune from solar cancer except for his conjunctiva which is not protected by pigment (Templeton, 1967). Europeans show a spectrum of susceptibility according to their pigmentation. In an indirect way genetic factors may influence the liability of an African to develop Burkitt’s lymphoma. Individuals of hemoglobin genotype AS which confers some protection against malaria have a significantly lower incidence of the tumor than those with the normal genotype AA (Morrow et al., 1971). Evidence is also accumulating that genetically determined enzymes may play a role in determining the susceptibility of individuals to some specific carcinogens (Brit. Med. J., 1974).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ahmed, N., and Cook, P. (1969). The incidence of cancer of the oesophagus in West Kenya. Br. J. Cancer 23: 302.
Alpert, M. E., Hutt, M. S. R., Wogan, G. N., and Davidson, C. S. (1971). Association between aflatoxin content of food and hepatoma frequency in Uganda. Cancer 28: 253.
Anthony, P. P. (1973a). Primary carcinoma of the liver: A study in 282 cases in Ugandan Africans. J. Pathol. 110: 37.
Anthony, P. P. (1973b). Malignant tumors of the kidney, bladder and urethra. In Tumours in a Tropical Country. A. C. Templeton, ed., p. 145. Heinemann Medical Books, London.
Aries, V., Crowther, J. S., Drasar, B. S., Hill, M. J., and Williams, R. E. O. (1969). Bacteria and the aetiology of cancer of the large bowel. Gut 10: 334.
Bagshawe, A., and Nganda, T. N. (1973). Hepatitis B antigen in a rural community in Kenya. Trans. Soc. Med. Hyg. 67: 663.
Baum, J. K., Holtz, F., Bookstein, J. J., and Klein, E. W. (1973). Possible association between benign hepatomas and oral contraceptives. Lancet 2: 926.
Bradshaw, E., and Schonland, M. (1974). Smoking, drinking and oesophageal cancer in African males in Johannesberg, South Africa. Br. J. Cancer 30: 157.
Bremner, C. G., and Ackerman, L. V. (1970). Polyps and carcinoma of the large bowel in the South African Bantu. Cancer 26: 991.
British Medical Bulletin (1971). 27:14–20.
British Medical Journal (1970). Genital herpes and cervical cancer. 4:256.
British Medical Journal (1974). Susceptibility to carcinogens in man. 1:169.
Buell, P., and Dunn, J. E. (1965). Cancer mortality among the Japanese Issei and Nisei of California. Cancer 18: 656.
Burkitt, D. P. (1962). Determining the climatic limitations of a children’s cancer common in Africa. Br. Med. J. 2: 1019.
Burkitt, D. P. (1969). Etiology of Burkitt’s lymphoma. J. Nat. Cancer Inst. 42:19. Burkitt, D. P. (1970). Relationship as a clue to causation. Lancet 2: 1237.
Burkitt, D. P. (1973a). Carcinoma of the colon and rectum. In Modern Trends in Oncology. R. W. Raven, ed., p. 227. Butterworth, London.
Burkitt, D. P. (1973b). Some diseases characteristic of modern western civilization. Clin. Radiol. 24: 271.
Burkitt, D. P., Hutt, M. S. R., and Slavin, G. (1968). CGnicopathological studies of cancer distribution in Africa. Br. J. Cancer 22: 1.
Burrell, R. J. W. (1962). Oesophageal cancer among the Bantu in the Transkei. J. Nat. Cancer. Inst. 28: 495.
Chou, S. T., and Gibson, J. B. (1970). The histochemistry of biliary mucins and the changes caused by infestation with Clonorchis sinensis. J. Pathol. 101: 185.
Clemmesen, J., Maisin, J., and Gigase, P. (1962). Cancer in Kivu and Ruanda-Urundi. Institut de Cancer, Université de Louvain.
Clifford, P. (1967). Malignant disease of the nasopharynx and paranasal sinuses in Kenya. In Cancer of the Nasopharynx. C. S. Muir and K Shanmugaratnam, eds., Vol. 1. UICC Monograph Series, Munksgaard, Copenhagen.
Clifford, P. (1970). On the epidemiology of nasopharyngeal carcinoma. Int. J. Cancer 5: 287.
Cook, P. (1971). Cancer of the oesophagus in Africa. Br. J. Cancer 25: 853.
Cook, P., and Burkitt, D. P. (1971). Cancer in Africa. Brit. Med. Bull. 27: 14.
Correa, P., and Llanos, G. (1966). Morbidity and mortality from cancer in Cali, Colombia. J. Nat. Cancer Inst. 36: 717.
Correa, P., and O’Conor, G. T. (1973). Geographic pathology of lymphoreticular tumours. J. Nat. Cancer Inst. 50: 1609.
Correa, P., Cuello, C., and Duque, E. (1970). Carcinoma and intestinal metaplasia of the stomach in Colombian migrants. J. Nat. Cancer Inst. 44: 297.
Correa, P., Sasano, N., Stemmermann, G. N., and Haenszel, W. (1973). Pathology of gastric carcinoma in Japanese populations: Comparisons between Miyagi Prefecture, Japan and Hawaii. J. Nat. Cancer Inst. 51: 1449.
Court Brown, W. M., Doll, R., and Bradford Hill, A. (1960). Incidence of leukaemia after exposure to diagnostic radiation in utero. Br. Med. J. 2: 1539.
Davies, J. N. P. (1973). Childhood tumours. In Tumours in a Tropical Country. A. C. Templeton, ed., p. 306. Heinemann Medical Books, London.
Davies, J. N. P., Elmes, S., Hutt, M. S. R., Mtimavalye, L. A. R., Owor, R., and Shaper, L. (1964). Cancer in an African Community, 1897–1956. An analysis of the records of Mengo Hospital, Kampala, Uganda. Brit. Med. J. 1: 259.
Davies, J. N. P., and Steiner, P. E. (1957). Cirrhosis and primary liver carcinoma in Ugandan Africans. Brit. J. Cancer 11: 523.
Davis, N. C., Herron, J. J., and McLeod, G. R. (1966). Malignant melanoma in Queensland. Lancet 2: 407.
Dodge, O. G. (1964). Tumours of the bladder and urethra associated with urinary retention in Uganda Africans. Cancer 17: 1433.
Dodge, O. G., and Kaviti, J. N. (1965). Male circumcision among the peoples of E. Africa and the incidence of genital cancer. E. Afr. Med. J. 42: 98.
Doll, R. (1969). The geographical distribution of cancer. Brit. J. Cancer 23: 1.
Doll, R. (1974). Quoted in: Cancer in Chinese migrants. Lancet 1:1027.
Doll, R., and Hill, A. B. (1953). Bronchial carcinoma: Incidence and aetiology. Brit. Med. J. 2: 521–585.
Doll, R., and Hill, A. B. (1964). The mortality of doctors in relation to their smoking habits. Brit. Med. J. 1: 1451.
Doll, R., Muir, C. S., and Waterhouse, J. A. H., eds. (1970). Cancer Incidence in Five Continents, Vol. II. UICC, Springer-Verlag, Berlin/Heidelberg/New York.
Doll, R., Payne, P. and Waterhouse, J. A. H., eds. (1966). Cancer Incidence in Five Continents, Vol. I. UICC, Springer-Verlag, Berlin/Heidelberg/New York.
Dutz, W., Asvadi, S., Sadri, S., and Kohout, E. (1971). Intestinal lymphoma and sprue: A systematic approach. Gut 12: 804.
Edington, G. M., and MacLean, C. M. U. (1965). A cancer rate survey in Ibadan, Western Uganda. Brit. J. Cancer 19: 471.
Hassan, A. M., Nilosev, B., Daoud, E. H., and Kashan, A. (1967). Malignant diseases of the upper respiratory tract in the Sudan. In Cancer in Africa. P. Clifford, C. A. Linsell, and G. L. Timms, eds., p. 307. East African Publ. House.
Elliott, R. I. K. (1964). On the prevention of carcinoma of the cervix. Lancet 1: 231.
Elwood, J. M., Lee, J. A. H., Walter, S. D., Mo, T., and Green, A. E. S. (1974). Relationship of melanoma and other skin cancers to latitude and ultraviolet radiation in the United States and Canada. Int. J. Epidemiol. 3: 325.
Fraumeni, J. K., and Mason, T. J. (1974). Cancer mortality among Chinese Americans, 195069. J. Nat. Cancer Inst. 52: 659.
Gibson, J. B. (1971). Parasites, Liver Disease and Liver Cancer,p. 42. I.A.R.C. Scientific Publ. No. 1., Lyon.
Hashem, M. (1961). The aetiology and pathogenesis of bilharzial bladder cancer. J. Egypt. Med. Assoc. 44: 857.
Hawksworth, G. M., and Hill, M. J. (1971). Bacteria and the N-nitrosation of secondary amines. Brit. J. Cancer 25: 520.
Heath, C. M., Falk, H., and Creech, J. L. (1974). Characteristics of cases of angiosarcoma of the liver among vinyl chloride workers in the United States. Annu. N.Y. Acad. Sci. 246: 231–236.
Henderson, B. E., Powell, D., Rosario, I., Keys, C., Hanisch, R., Young, M., Casagrande, J., Gerhms, V., and Pike, M. C. (1974). An epidemiologic study of breast cancer. J. Nat. Cancer Inst. 53: 609.
Henle, W., Henle, G., Ho, H. C., Burtin, P. Cachin, Y. Clifford, P., DeSchryver, A., de Thé, Q., Diehl, V., Klein, G. (1970). Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma. J. Nat. Cancer Inst. 44: 225.
Herbst, A. L., Kurman, R. J., Scully, R. E., and Poskanzer, D. C. (1972). Clear cell adenocarcinoma of the genital tract in young females. N. Engl. J. Med. 287: 1259.
Higginson, J., and Oettlé, A. G. (1960). Cancer incidence in the Bantu and cape coloured races of South Africa: Report of a cancer survey in the Transvaal (1953–55). J. Nat. Cancer Inst. 24: 589.
Hill, M. J. (1971). The effect of some factors on the faecal concentration of acid steroids, neutral steroids and urobilins. J. Pathol. 104: 239.
Hill, M. J., and Aries, V. C. (1971). Faecal steroid composition and its relationship to cancer of the large bowel. J. Pathol. 104: 129.
Hill, M. J., Drasar, B. S., Aries, V. C., Crowther, J. S., Hawksworth, G. M. and Williams, R. E. O. (1971). Bacteria and aetiology of cancer of the large bowel. Lancet 1: 95.
Hutt, M. S. R., Burkitt, D. P. (1965). Geographical distribution of cancer in East Africa. Brit. Med. J., 2: 719.
Hutt, M. S. R., and Templeton, A. C. (1971). The geographical pathology of bowel cancer and some related diseases. Proc. R. Soc. Med. 64: 962.
International Journal of Cancer (1970). 6:1–9.
James, P. D., Taylor, C. W., and Templeton, A. C. (1973). Tumours of the Female Genitalia. In Tumours in a Tropical Country. A. C. Templeton, ed., p. 101. Heinemann Medical Books, London.
Jussawalla, D. J., Deshpande, V. A., Haenszel, W., and Natekar, M. V. (1970). Differences observed in the site incidence of cancer between the Parsi Community and the total population of Greater Bombay. Brit. J. Cancer 24: 56.
Kafuko, G. W., and Burkitt, D. P. (1970). Burkitt’s lymphoma and malaria. Int. J. Cancer 6: 1.
Keen, P., and Martin, P. (1971). Is aflatoxin carcinogenic in Man? The evidence in Swaziland. Trop. Geogr. Med. 23: 44.
Kmet, J., and Mahboubi, E. (1972). Oesophageal cancer in the Caspian Littoral of Iran. Science 175: 846.
Iversen, U., and Iversen, O. H. (1973). Tumours of the skin. In Tumours in a Tropical Country. A. C. Templeton, ed., p. 180. Heinemann Medical Books, London.
Lawrence, J. C. (1936). Gastrointestinal polyps. Amer. J. Surg. 31: 499.
Lewis, M. G. (1967). Malignant melanoma in Uganda. Brit. J. Cancer 21: 483.
Liang, P. C., and Tung, C. (1959). Morphologic study and etiology of primary liver carcinoma and its incidence in China. Chinese Med. J. 79: 336.
Lin, J. J., Lin, C., and Svoboda, D. J. (1974). Long term effects of aflatoxin Bi and viral hepatitis in marmosets. Lab. Invest. 30: 267.
Malhotra, S. L. (1971). A study of the uterine cervix with special reference to causation and prevention. Brit. J. Cancer 15: 62.
Matsudo, H., Hodgkin, N. M., and Tanaka, A. (1974). Japanese gastric cancer. Potentially carcinogenic silicates (talc) from rice. Arch. Pathol. 97: 366.
McMahon, B., Cole, P., Lin, T. M., Lowe, C. R., and Mirra, A. P. (1970). Age at first birth and breast cancer risk. Bull. WHO 43: 209.
Mole, R. H. (1974). Antenatal irradiation in childhood cancer. Br. J. Cancer 30: 199.
Morrow, R. H., Pike, M. C., Smith, P. G., Ziegler, J. L., and Kisuule, A. (1971). Burkitt’s Lymphoma: A Time-space cluster of cases in Bwamba County of Uganda. Br. Med. J. 2: 491.
Muir, C. S., and Shanmugaratnam, K. eds. (1967). Cancer of the Nasopharynx, Vol. 1. UICC Monogr. Series, Munksgaard, Copenhagen.
Newberne, P. M., and Butler, W. H. (1969). Acute and chronic effects of aflatoxin on the liver of domestic and laboratory animals. Cancer Res. 29: 236.
Painter, N. S. (1964). The aetiology of diverticulosis of the colon with special reference to the action of certain drugs on the behaviour of the colon. Ann. R. Coll. Surg. Eng. 34: 98.
Painter, N. S. (1967). Diverticulosis of the colon-Fact and speculation. Am. J. Dig. Dis. 12: 222.
Payet, M. (1957). Primary cancer of the liver: Statistical anatomical and aetiological considerations. Acta Un. Int. Cancer 13: 860.
Payet, M., Saimot, G., Couland, J. P., et al. (1971). L’antigène Australie chez l’Africain. Presse Méd. 79: 52.
Paymaster, J. C. (1962). Some observations on oral and pharyngeal carcinomas in State of Bombay. Cancer 15: 578.
Peers, F. G., and Linsell, C. A. (1973). Dietary aflatoxins and liver cancer-A population based study in Kenya. Br. J. Cancer 27: 473.
Prates, M. D., and Tones, F. O. (1965). A cancer survey in Lourenço Marques, Portuguese East Africa. J. Nat. Cancer Inst. 35: 729.
Quinland, W. S., and Cuff, J. R. (1940). Primary carcinoma in the negro. Arch. Pathol. 30: 393.
Rappaport, H., Ramot, B., Hulu, N., and Park, J. K. (1972). The pathology of so-called Mediterranean abdominal lymphoma with malabsorption. Cancer 29: 1502.
Reddy, C. R. M. (1974). Carcinoma of the hard palate in India. J. Nat. Cancer Inst. 53: 609.
Robertson, N. A., Harington, J. S., and Bradshaw, E. (1971). The cancer pattern in Africans at Baragwanath Hospital, Johannesberg. Br. J. Cancer 25: 378.
Schmauz, R., and Jain, D. K. (1971). Geographical variations of carcinoma of the penis in Uganda. Br. J. Cancer 25: 25.
Shank, R. C., Bhamarapravati, N., Gordon, J. E., and Wogan, G. N., (1972). Dietary aflatoxins and human liver cancer. Foods Cosmet. Toxicol. 10: 171.
Shanmugaratnum, K., Muir, D. S., Tow, S. H., et al. (1971). Rates per 100,000 births and incidence of choriocarcinoma and malignant mole in Singapore Chinese and Malays.
Comparisons with Connecticut, Norway and Sweden. Int. J. Cancer 8: 165.
Simons, M. J., Yu, M., Chew, B. K., Tan, A. Y. O., Yap, Y. E. H., Sea, C. S., Fung, W. P., and Shanmugaratnam, K. (1971). Australia antigen in Singapore Chinese patients with hepatocellular carcinoma. Lancet 1: 1149.
Siurala, M., Kekki, M., Varis, K., Isokoshi, M., and Ihmaki, T. (1972). Gastritis and Gastric Cancer. Br. Med. J. 3: 530.
Skinner, M. E. G. (1967). Malignant disease of the gastro-intestinal tract in the Rhodesian African. Nat. Cancer Inst. Monogr. 25: 57.
Steinitz, R. (1974). Communication to UICC Conference in Florence.
Stemmermann, G. N. (1970). Patterns of disease among Japanese living in Hawaii. Arch. Environ. Health 20: 266.
Stewart, A., Webb, J., and Hewitt, D., (1958). A survey of childhood malignancies. Br. Med. J. 1: 1495.
Tansurat, P. (1961). Cancer of the oral cavity and oesophagus in Thais and Chinese. Acta Univ. Int. Cancer 17: 877.
Templeton, A. C. (1967). Tumours of the eye and adnexa in Africans of Uganda. Cancer 20: 1689.
Templeton, A. C., and Bianchi, A. (1972). Bias in an African Registry. Int. J. Cancer 10: 186.
Templeton, A. C., Buxton, E., and Bianchi, A. (1972). Cancer in Kayadondo County, Uganda, 1968–1970. J. Nat. Cancer Inst. 48: 865.
Templeton, A. C., and Hutt, M. S. R. (1973). Distribution of tumours in Uganda. In Tumour in a Tropical Country. A. C. Templeton, ed., p. 1. Heinemann Medical Books, London.
Tuyns, A. J. (1970). Cancer of oesophagus: Further evidence of the relation to drinking habits in France. Int. J. Cancer 5: 152.
Tuyns, A. J., and Massé, L. M. F. (1973). Mortality from cancer of the oesophagus in Brittany. Int. J. Epidemiol. 2: 241.
Urbach, F. (1969). Geographical pathology of skin cancer. In The Biological Effects of Ultraviolet Irradiation. F. Urbach, ed. Pergamon Press, London.
Vogel., C. L., Anthony, P. P., Sadikali, F., Baker, L. F., and Peterson, M. R. (1972). Hepatitis-associated antigen and antibody in hepatocellular carcinoma. J. Nat. Cancer Inst. 48: 1583.
Wedderburn, N. (1970). Effect of concurrent malarial infection on development of virus-induced lymphoma in Balb/c mice. Lancet 2: 1114.
Wogan, G. N. (1966). Chemical nature and biological effects of aflatoxin. Bacteriol. Rev. 30: 460.
Wynder, E. L., Kajitani, T., Ishikawa, S., Dodo, H., and Takano, A. (1969). Environmental factors of cancer of the colon and rectum. Cancer 23: 1210.
Wynder, E. L., Lemon, F. R., and Bross, I. J. (1959). Cancer and coronary artery disease among Seventh-Day Adventists. Cancer 12: 101.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Plenum Publishing Corporation
About this chapter
Cite this chapter
Burkitt, D., Hutt, M. (1977). Epidemiology. In: Raven, R.W. (eds) Principles of Surgical Oncology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2301-3_10
Download citation
DOI: https://doi.org/10.1007/978-1-4684-2301-3_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-2303-7
Online ISBN: 978-1-4684-2301-3
eBook Packages: Springer Book Archive