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Interactions of Lipoproteins with Cells in Culture

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Low Density Lipoproteins

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Abstract

Study of the interactions of lipoproteins with whole cells is very appropriate to the understanding of the functions and metabolism of these macromolecules. Because of their size, lipoproteins could not be expected to enter cells by simple penetration of, or solution in, the plasma membrane. Some form of specific reaction mechanism would seem to be necessary, and indeed this appears to be the case. Cell culture offers many advantages for this type of investigation. Individual cell types can be studied independently from the interactions and compensations which complicate the picture in the whole animal or even in isolated organs. Genetically mutant cells can be compared to their normal counterparts, and this approach has been most fruitful. Obviously, control of the environment is greater in cell culture than in more complex biological systems, and sampling error is lower.

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  1. Division of Richardson-Merrell, Inc., Merrell-National Laboratories, Cincinnati, Ohio, USA

    L. Fred Roensch & Thomas R. Blohm

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  1. L. Fred Roensch
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  1. The Upjohn Company, Kalamazoo, Michigan, USA

    Charles E. Day

  2. Department of Biochemistry, University of Louisville School of Medicine, Louisville, Kentucky, USA

    Robert S. Levy

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Roensch, L.F., Blohm, T.R. (1976). Interactions of Lipoproteins with Cells in Culture. In: Day, C.E., Levy, R.S. (eds) Low Density Lipoproteins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2250-4_4

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  • DOI: https://doi.org/10.1007/978-1-4684-2250-4_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2252-8

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