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Animal Models of Violence and Hyperkinesis

Interaction of Psychopharmacologic and Psychosocial Therapy in Behavior Modification

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Animal Models in Human Psychobiology

Abstract

In reviewing the dramatic discrepancy between the many favorable clinical reports on meprobamate and a number of negative laboratory studies on this drug, Gerard (1957), in his usual elegant and succinct manner, summarized the situation as follows: “On the one hand, laboratory studies indicate that meprobamate is quite inert; on the other hand, a great number of takers seem to experience some benefit, and clinical reports included in these pages—many seemingly well controlled and convincing enough as reported—indicate a definite action. From this, one must conclude either that the experimenters have not yet found the right thing to test—which would not be surprising, since we are dealing with agents active on the nuances of complex human behavior for which it is difficult to find electrical or chemical indicators, either in the laboratory or in the patient—or else the clinical impressions are wrong. ... I doubt that the latter is the case, especially because of the genuine awareness of the problem of controls that exists today among the better clinicians and laboratory workers handling these problems.”

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Authors and Affiliations

  1. Laboratory of Cerebrovisceral Physiology, Division of Behavioral and Neurobiological Sciences, Department of Psychiatry, College of Medicine, Ohio State University, Columbus, Ohio, USA

    Samuel A. Corson, E. O’Leary Corson, L. Eugene Arnold & Walter Knopp

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  1. Samuel A. Corson
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  2. E. O’Leary Corson
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  3. L. Eugene Arnold
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  4. Walter Knopp
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Editors and Affiliations

  1. Kittay Scientific Foundation, USA

    George Serban

  2. Department of Psychiatry, Rutgers Medical School, USA

    Arthur Kling (Professor) (Professor)

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Corson, S.A., Corson, E.O., Arnold, L.E., Knopp, W. (1976). Animal Models of Violence and Hyperkinesis. In: Serban, G., Kling, A. (eds) Animal Models in Human Psychobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2184-2_8

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