Abstract
Biochemical processes are often studied in prokaryotic systems due to a lower degree of complexity in the organization of structural and enzymatic components in these simple organisms. In prokaryotic cells biochemical processes and the components associated with these processes are often compartmentalized in cell organelles such as the nucleus, mitochrondria, microsomes and etc. In eukaryotic cells, cellular DNA and DNA synthesis are localized in the nucleus. Although one might assume that all enzymes involved in DNA synthesis and maintenance are localized in the nucleus, experimental findings contradict this assumption. The number of DNA polymerases and their intracellular locations in an eukaryotic cells are probably related to their in vivo functions, and to the complex control mechanisms in the replication and maintenance of DNA.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Meyer, R.R. & Simpson, M.V. (1970) J. Biol. Chem. 245: 3426.
Chang, L.M.S. & Bollum, F.J. (1972) Biochemistry 11: 1264.
Chang, L.M.S. & Bollum, F.J. (1972) J. Biol. Chem. 247: 7948.
Chang, L.M.S., Brown, McKay & Bollum, F.J. (1973) J. Mol. Biol. 74: 1.
Chang, L.M.S., Cassani, G.R. & Bollum, F.J. (1972) J. Biol. Chem. 247: 7718.
Chang, L.M.S. & Bollum, F.J. (1972) Biochem. Biophys. Res. Comm. 46: 1354.
Chang, L.M.S. (1973) J. Biol. Chem. 248:
Kornberg, A. (1969) Science 163: 1410.
Brutlag, D. & Kornberg, A. (1972) J. Biol. Chem. 247: 241.
Chang, L.M.S. & Bollum, F.J. (1973) J. Biol. Chem. 248:
Bollum, F.J. (1960) J. Biol. Chem. 235: 2399.
Deutscher, M.P. & Kornberg, A. (19697V. Biol. Chem. 244: 3019.
Hershfield, M.S. & Nossal, N.G. (1972) J. Biol. Chem. 247: 3393.
Chang, L.M.S. & Bollum, F.J. (1972) Science 175: 1116.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1974 Plenum Press, New York
About this chapter
Cite this chapter
Bollum, F.J., Chang, L.M.S. (1974). Eukaryotic DNA Polymerases. In: Kolber, A.R., Kohiyama, M. (eds) Mechanism and Regulation of DNA Replication. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2124-8_21
Download citation
DOI: https://doi.org/10.1007/978-1-4684-2124-8_21
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-2126-2
Online ISBN: 978-1-4684-2124-8
eBook Packages: Springer Book Archive