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Initiation of DNA Synthesis

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Mechanism and Regulation of DNA Replication

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Abstract

All the polymerases studied have two basic features: (i) a phosphodiester bridge is formed between the 3’-phosphate group of a deoxyribonucleotide and the 5’-hydroxy1 group at the growing end of a DNA chain called primer DNA; the chain growth is 5’→ 3’; and (ii) each deoxynucleotide added to the chain is selected by base-pair matching to a DNA chain called template DNA.

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References

  1. Kornberg, A. Active Center of DNA Polymerase, Science 163: 1410 (1969).

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Author information

Authors and Affiliations

  1. Department of Biochemistry, Stanford University Medical School, Stanford, California, USA

    Arthur Kornberg

Authors
  1. Arthur Kornberg
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Editor information

Editors and Affiliations

  1. Virus Research Institute, German Cancer Research Center, Heidelberg, Germany

    Alan R. Kolber

  2. Institute of Molecular Biology, University of Paris, Paris, France

    Masamichi Kohiyama

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© 1974 Plenum Press, New York

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Kornberg, A. (1974). Initiation of DNA Synthesis. In: Kolber, A.R., Kohiyama, M. (eds) Mechanism and Regulation of DNA Replication. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2124-8_2

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  • DOI: https://doi.org/10.1007/978-1-4684-2124-8_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2126-2

  • Online ISBN: 978-1-4684-2124-8

  • eBook Packages: Springer Book Archive

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